医学
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审稿天数=录用日期-收稿日期;保留 PDF/DOI/网页源链接
Structural basis of diverse substrate recruitment by the HIV-1 Vpr-hijacked CRL4(VprBP) E3 ligase
作者Dianhong Wang; Weijia Ding; Jingwei Xu; Ruofan Li; Tamino Cairoli; Qi Liu; Yiying Zhu; Ye Xiang
作者单位1. Beijing Frontier Research Center for Biological Structure, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, China; 2. Institute of Molecular Biology and Biophysics, ETH Zürich, Zürich, Switzerland; 3. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China; 4. School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; 5. Cryo-EM Knowledge Hub, ETH Zürich, Zürich, Switzerland; 6. Department of Chemistry, Tsinghua University, Beijing, China; 7. Tsinghua-Peking Joint Center for Life Sciences, Beijing, China; 8. SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine, Taiyuan, China
A fish-specific E3 ubiquitin ligase NHRE3 suppresses antiviral immunity by degrading ISG15 via ubiquitination
作者Juhong Xie; Jiayi Lei; Qinxue Zhu; Bin Gui; Yongming Li; Yaping Wang; Rong Huang
作者单位1. Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; 2. College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China
Complexome profiling of mitochondria in the myzozoan parasite of oysters, Perkinsus marinus
作者Andrew E. Maclean; Orsola Iorillo; Drahomíra Faktorová; Monika Singh; Suzanne McGill; Julius Lukeš; Lilach Sheiner
作者单位1. Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom; 2. Centre for Parasitology, University of Glasgow, Glasgow, United Kingdom; 3. School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom; 4. Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic; 5. Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic; 6. College of Medical, Veterinary & Life Sciences Shared Research Facilities, University of Glasgow, Glasgow, United Kingdom
Hijacking of host PCNA by circovirus replication-associated protein to recruit POLD1 drives viral DNA replication and is inhibited by R428
作者Lei Zhu; Guan Zhang; Yingying Pu; Wenyu Wang; Zhanyan Zhang; Jiasai Kang; Haoshu Zhang; Lingling Chang; Le Shi; Yong Huang; Dewen Tong; Qian Du
作者单位1. College of Veterinary Medicine, Northwest A&F University, Yangling, China; 2. Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China; 3. Engineering Research Center of Efficient New Vaccines for Animals, Ministry of Education, Yangling, China; 4. Key Laboratory of Ruminant Disease Prevention and Control (West), Ministry of Agriculture and Rural Affairs, Yangling, China; 5. Engineering Research Center of Efficient New Vaccines for Animals, Universities of Shaanxi Province, Yangling, China
Serine protease inhibitor from Trichinella spiralis ameliorates diet-induced obesity and adipose tissue inflammation through TIM-3-dependent macrophage reprogramming
作者Mingwei Tong; Ge Liu; Guidong Ren; Wangxuan Zhang; Yuyu Qiao; Xiaodan Yang; Weiping Fan; Hui Yang; Yong Yang
作者单位1. Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2. School of Basic Medical Sciences, Shanxi Medical University, Jinzhong, China; 3. Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Shanxi Medical University, Jinzhong, China; 4. Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, and Shanxi Key Laboratory of Cellular Physiology, Taiyuan, China; 5. Department of Infectious Diseases, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
A bacterial pangenome association study identifies a role for polyamine metabolism and alkaline tolerance in middle ear infections
作者Jocelyn A. Hammond; Rachel L. Ehrlich; Ariel Gonzalez; Begoña Euba; Kevin M. Raible; Jill M. Lawrence; Ari B. Gordon; Evangeline Williams; Mary C. Marino; Jason Limbo; Steven Lang; Bhaswati Sen; Sergey V. Balashov; Azad Ahmed; Junkal Garmendia; Joris Beld; Garth D. Ehrlich; Michael E. Pichichero; Ravinder Kaur; Joshua Chang Mell
作者单位1. Department of Microbiology & Immunology, Drexel University College of Medicine; Center for Genomic Sciences, Institute of Molecular Medicine and Infectious Disease; Drexel University, Philadelphia, Pennsylvania, United States of America; 2. Instituto de Agrobiotecnología, Consejo Superior de Investigaciones Científicas-Gobierno de Navarra, Mutilva, Spain; 3. Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Madrid, Spain; 4. Conexión Antimicrobial Resistance-AMR, CSIC, Madrid, Spain; 5. Department of Otolaryngology – Head and Neck Surgery; Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America; 6. Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester General Hospital, Rochester, NewYork, United States of America
GM000287 is a conserved determinant of serum resistance and virulence in Klebsiella pneumoniae
作者Xiaomin Lin; Junjun Jia; Zilin Zhuang; Yixin Mo; Xiaoxin Pan; Kaining Zhong; Ping Shen; Quanjiang Ji; Kai Zhou; Liang Yang; Yonghong Xiao; Chunfu Yang
作者单位1. School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China; 2. SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, China; 3. School of Medicine, Southern University of Science and Technology, Shenzhen, China; 4. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; 5. School of Physical Science and Technology, Shanghai Tech University, Shanghai, China; 6. Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen University, Shenzhen, China; 7. Shenzhen Key Laboratory of Respiratory Diseases, Shenzhen Clinical Research Center for Respiratory Disease, Shenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, China
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