医学
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Depot-central synchronization of a pharmacokinetic model with capacity-limited saturable absorption
作者Xiaotian Wu; Yuting Jin; Zhong Jin; Jun Li
作者单位1. School of Science, Shanghai Maritime University, Shanghai, P. R. China; 2. Faculté de pharmacie, Université de Montréal, Montréal, Canada; 3. Centre de recherches mathématiques, Université de Montréal, Montréal, Canada
Diffusion models for virtual populations and pharmacometric simulations
作者Prathamesh Kishor Gadgil; Shamith Manjunath Poojari; Murali Ramanathan
作者单位1. Artificial Intelligence & Clinical Pharmacology Laboratory, 355 Pharmacy, Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, USA
Construction of a translational whole-body physiologically based pharmacokinetic model to investigate the biodistribution of lipid nanoparticle-based mRNA therapeutics for intracellular protein targets
作者Kenji Miyazawa; Hojjat Bazzazi; Wei Gao
作者单位1. Moderna Therapeutics, Cambridge, United States; 2. EMD Group, Boston, United States
External validation of population pharmacokinetic models of adalimumab in adult patients with inflammatory bowel disease: towards model-informed precision dosing
作者Irene Aguilo-Lafarga; Tonet Serés-Noriega; Vicente Gimeno-Ballester; Pilar Antonia Corsino Roche; Raquel Vicente Lidon; Eva Maria Sierra Moros; Sonia Gallego; Santiago Garcia Lopez; Maria Reyes Abad Sazatornil
作者单位1. Hospital Pharmacy Service, Hospital Universitario Miguel Servet, Zaragoza, Spain; 2. Hospital Pharmacy Service, Hospital Universitario San Jorge, Huesca, Spain; 3. Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain; 4. Endocrinology and Nutrition, Centro Médico Milenium, Zaragoza, Spain; 5. Inflammatory Bowel Disease Unit, Gastroenterology and Digestive System Department, Hospital Universitario Miguel Servet, Zaragoza, Spain
Ehrlich occupancy time: beyond \(k_\textrm{off}\) to a complete residence time framework
作者Justin Eilertsen; Santiago Schnell; Sebastian Walcher
作者单位1. Mathematical Reviews American Mathematical Society, Ann Arbor, USA; 2. Department of Mathematics, Dartmouth, Hanover, USA; 3. Department of Biochemistry & Cell Biology, and Department of Biomedical Data Sciences Geisel School of Medicine at Dartmouth, Hanover, USA; 4. Fachgruppe Mathematik, RWTH Aachen, Aachen, Germany
On the structural identifiability of nonlinear models of ligand binding dynamics
作者Carla White; Vivi Rottschäfer; Lloyd Bridge
作者单位1. Swansea University, Swansea, United Kingdom; 2. Leiden University, Leiden, Netherlands; 3. University of Amsterdam, Amsterdam, Netherlands; 4. University of the West of England, Bristol, England
QSP model for AAV-mediated antibody delivery in rat brain
作者Shufang Liu; Ekram Ahmed Chowdhury; Shengjia Wu; Guy Meno-Tetang; Dhaval K. Shah
作者单位1. Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, USA; 2. Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
Differential expression of monoclonal antibody in rat brain following systemic and local administration of AAV
作者Ekram Ahmed Chowdhury; Guy Meno-Tetang; Shufang Liu; Shengjia Wu; Navya Desireddy; Anthony Jerez; Leeha Mahmood; Aneesh Rajwade; Sidhaarth Bulusu; Tanguy Jamier; Annalisa Nucitelli; Fiona Cusdin; Claire Dobson; Dhaval K. Shah
作者单位1. Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York, Buffalo, USA; 2. Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK; 3. Preclinical and Clinical Pharmacology, Neurocrine BioSciences, London, UK; 4. Cell Gene and RNA Therapy, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK
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