医学
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Age- and sex-dependent heterogeneity during LPS-induced murine acute lung injury
作者Chantal Crispens; Annett Wilken-Schmitz; Valentin Dern; Abd Rahman Rahimi; Enrico Madau; Nadine Chiara Frigger; Josefine Jakob; Björn Häupl; Thomas Oellerich; Andreas Weigert; Steven R. Talbot; Kai Zacharowski; Ulrike Heinicke; Andreas von Knethen
作者单位1. Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe University Frankfurt, University Hospital Frankfurt, Frankfurt Am Main, Germany; 2. Frankfurt Cancer Institute, Frankfurt, Germany; 3. Department of Hematology and Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany; 4. German Cancer Consortium (DKTK), a Partnership Between DKFZ and UCT Frankfurt-Marburg, Frankfurt Am Main, Germany; 5. Goethe University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Frankfurt, Germany; 6. Department for Immunity of Inflammation, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 7. Hannover Medical School, Institute for Laboratory Animal Science, Hannover, Germany; 8. Institute of Medical Statistics, RWTH Aachen University Hospital, Aachen, Germany
CD8 + effector memory and regulatory T cell dynamics predict subclinical atherosclerotic plaque formation in healthy aging
作者Christopher Weyh; Vincent Größer; Luciele Guerra Minuzzi; Torsten Frech; Kristina Gebhardt; Svenja Nolte; Theresa Regine Dombrowski; Tim Böttrich; Manuela Andrea Hoffmann; Natascha Sommer; Robert Ringseis; Klaus Eder; Samuel Sossalla; Pascal Bauer; Karsten Krüger
作者单位1. Department of Exercise Physiology and Sports Therapy, Institute of Sports Science, Justus- Liebig-University, Giessen, Germany; 2. Institute for Preventive Medicine of the German Armed Forces, Andernach, Germany; 3. Department of Cardiology and Angiology, Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig-University Giessen, Giessen, Germany; 4. Faculty of Sport Sciences and Physical Education, CIPER, University of Coimbra, Coimbra, Portugal; 5. Department of Nuclear Medicine, University Medical Center of the Johannes Gutenberg- University, Mainz, Germany; 6. Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio- Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany; 7. Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Giessen, Germany; 8. Center for Sustainable Food Systems, Justus Liebig University Giessen, Giessen, Germany; 9. Department of Cardiology, Kerkhoff Clinic GmbH, Bad Nauheim, Germany
IL-35 promotes synovial fibroblast senescence via activation of cGAS-STING-TBK1-IRF3 pathway in rheumatoid arthritis
作者Ziliang Yu; Zeyu Liu; Jianbo Fan; Yixuan Li; Jiafeng He; Jiawei Zhang; Pengfei Fu; Dagong Gao; Fei Xia; Youhan Mei; Rui Xu; Jie Hao; Wei Liu; Haiping Zhang
作者单位1. Department of Joint and Sports Medicine, Nantong First People’s Hospital, Southeast University, Nantong, China; 2. Department of Joint and Sports Medicine, Nantong Clinical College, Nantong University, Nantong, China; 3. School of Medicine, Southeast University, Nanjing, China; 4. Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; 5. Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, China; 6. Department of Orthopaedic Surgery, Nantong First People’s Hospital, Nantong, China
Cellular senescence: the “hidden driver” in chronic inflammatory skin disorders
作者Huifang Liang; Junqin Li; Kaiming Zhang
作者单位1. Shanxi Key Laboratory of Stem Cells for Immunological Dermatosis, State Key Breeding Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Peking University First Hospital Taiyuan Hospital, Taiyuan, China
Reduced NK cell frequency in older patients with evolving fractures is linked to a distinct inflammatory cytokine profile
作者Julia P. Moch; Jolane Kappes; Rodrigo Gutierrez Jauregui; Hagen Schmaus; Malou-Sophie Dietrich; Daniel A. Thies; Lennart M. Roesner; Thomas Werfel; Reinhold Förster; Dorothee von Witzendorff; Jennifer Debarry; Marcel Winkelmann; Swantje Oberthür; Jan-Dierk Clausen; Manfred Gogol; Markus Cornberg; Anke R. M. Kraft; Christian Niehaus
作者单位1. Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany; 2. Department of Trauma Surgery, Hannover Medical School, Hannover, Germany; 3. Twincore, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School, Hannover, Germany; 4. Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany; 5. Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany; 6. Institute of Immunology, Hannover Medical School, Hannover, Germany; 7. Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany; 8. German Center for Infection Research (DZIF), Partner-Site Hannover-Braunschweig, Hannover, Germany
An immune-associated mitochondrial DNA variant with sex differences reveals a putative novel microprotein called MASL
作者Ana R. Silverstein; Thalida E. Arpawong; Eileen M. Crimmins; Tae Jung Oh; Rong Lu; Melanie Flores; Hiroshi Kumagai; Junxiang Wan; Hemal H. Mehta; Kelvin Yen; Brendan Miller; Yeachan Lee; Anna Nogalska; Pinchas Cohen
作者单位1. Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA; 2. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea; 3. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; 4. Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, USA; 5. Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, USA; 6. Clayton Foundation Peptide Biology Laboratories, The Salk Institute for Biological Studies, San Diego, USA
Immune risk phenotype and long-term mortality after community-acquired pneumonia in older adults: clinical and immune determinants
作者Sandra Clotet-Vidal; Teresa Franco-Leyva; Encarna Saez Prieto; Laura Feltrer Martinez; Alvaro Izquierdo Cardenas; Laura Martínez-Martínez; Jordi Casademont Pou; Olga H. Torres Bonafonte
作者单位1. Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 2. Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain; 3. Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain; 4. Immunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 5. Geriatrics Unit, Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Insights into the heterogeneity of pneumococcal polysaccharide vaccine immunogenicity in older adults
作者M. Visser; Y. Kuijpers; I. Tcherniaeva; D. M. van Rooijen; L. G. H. de Rond; M. L. de Zeeuw-Brouwer; A. Bonačić Marinović; H. Richardson; K. M. Mulvihill; D. Goldblatt; W. M. M. Verschuren; H. S. J. Picavet; M. I. de Jonge; G. den Hartog; A. M. Buisman
作者单位1. Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands; 2. Laboratory of Medical Immunology, Radboud UMC, Nijmegen, The Netherlands; 3. Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands; 4. Centre for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands; 5. Great Ormond Street Institute of Child Health, University College London, London, UK; 6. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Immunoinflammatory biomarkers for sepsis-associated acute kidney injury: a multicenter prospective cohort study
作者Wenliang Ma; Xin Zhang; Jingyi Wang; Jin Zhang; Xiaoxia Guo; Wenxiong Li; Na Cui
作者单位1. Department of Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; 2. Department of Critical Care Medicine, Beijing Chest Hospital, Capital Medical University & Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China
High-dose quadrivalent influenza vaccine in older adults with or without cardiovascular risk: a meta-analysis of randomized trials on 511,890 participants
作者Mohamed S. Elgendy; Abdalhakim Shubietah; Ameer Awashra; Mohamed Rifai; Mohanad Qwaider; Mohamed A. Faheem; Momin A. Abuwatfa; Mahmoud Ismayl; Mohammad Alqadi
作者单位1. Faculty of Medicine, Tanta University, Tanta, Egypt; 2. Department of Medicine, Advocate Illinois Masonic Medical Center, Chicago, USA; 3. Department of Medicine, An-Najah National University, Nablus, Palestine; 4. Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt; 5. Division of Medicine, University of Toledo, Toledo, USA; 6. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, USA; 7. Division of Cardiovascular Medicine, University of Toledo, Toledo, USA
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