医学
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13 篇有效样本 · 按发表日期由新到旧排列
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Human amniotic mesenchymal stromal cell-derived extracellular vesicles reprogram microglia and prevent neurodegeneration in experimental models of Alzheimer’s disease
作者Andrea Papait; Francesca Natale; Antonietta Rosa Silini; Ida Nifo Sarrapochiello; Elisa Orecchini; Raimondo Sollazzo; Marco Rinaudo; Serafina Farigu; Nicoletta Garofalo; Giulia Mantini; Guido Maria Giuffrè; Pietro Romele; Elvira Ragozzino; Alice Dellaria; Luciano Giacò; Camillo Marra; Cristian Ripoli; Claudio Grassi; Ornella Parolini; Salvatore Fusco
作者单位1. Dipartimento di Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome, Italy; 2. Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 3. Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; 4. Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 5. UOS Computational Biology and Bioinformatics GSTeP, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 6. Dipartimento di Psicologia, Università Cattolica del Sacro Cuore, Milano, Italy; 7. Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy
The gut neuroepithelial unit as a neurodegeneration-relevant interface in the gut–brain axis
作者Siqi Guo; Rui Guo; Qingyu Zhang; Liyuan Fu; Huaxu Zhu; Qichun Zhang
作者单位1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China; 2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, China; 3. School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China; 4. School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China; 5. Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing, University of Chinese Medicine, Nanjing, China
Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases
作者Shixin Ding; Jiguang Yang; Ze Wang; Ruiliang Bai; Kuiying Yin; Lei Jin; Maximilian Kueckelhaus; Sven G. Meuth; Ming Xiao; Gang Hu
作者单位1. Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, China; 2. Department of Geriatric Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China; 3. Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China; 4. School of Brain Science and Brain Medicine & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China; 5. Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing, China; 6. Department of Plastic and Reconstructive Surgery, Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany; 7. Department of Neurology, University Hospital Muenster, Muenster, Germany
Phase separation in neurodegenerative disorders: a metabolic perspective on protein aggregation and therapeutic targeting
作者Shujun Peng; Hui Chen; Guowei Yin; Alexei Verkhratsky; Chenju Yi
作者单位1. Department of Geriatrics, Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China; 2. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia; 3. Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; 4. Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China; 5. Guangdong Provincial Key Laboratory of Digestive Cancer Research, Shenzhen, China; 6. Tianfu Jincheng Laboratory, Chengdu, China; 7. Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research, Shenzhen, China
HSPA8 orchestrates SNARE complex assembly to drive extracellular vesicle-mediated spread of p-tau217 in Alzheimer's disease
作者Bin Xu; Zhen Guo; Jun Chen; Yazhou Xie; Pan Wang; Xiao Xiong; Jiayi Yu; Zhi Xu; Yuan Fu; Zhuoqing Lan; Guoping Peng; Jing Zhang
作者单位1. Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2. Nanhu Brain-computer Interface Institute, Hangzhou, China; 3. Lingang Laboratory, Shanghai, China; 4. School of Nursing and Health, Henan Medical College, Zhengzhou University, Zhengzhou, China; 5. School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China; 6. Department of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; 7. National Human Brain Bank for Health and Disease, Zhejiang University, Hangzhou, China
Bridging the gap: neuroinflammation and the dawn of precision medicine in amyotrophic lateral sclerosis
作者Lu Tang; Dongsheng Fan
作者单位1. Department of Neurology, Peking University Third Hospital, Beijing, China; 2. Beijing Key Laboratory of Innovative Diagnostics, Therapeutics and Translational Research for Neurological Rare Disorders, Peking University Third Hospital, Beijing, China
PCSK9 inhibitors in neurodegenerative disorders: mechanisms, therapeutic potential, and clinical implications
作者Jia Dong James Wang; Andrea York Tiang Teo; Bin Xiao; Yinxia Chao; Zhi Dong Zhou; Brendan Jen-Wei Tan; Ling-Ling Chan; Elvira Rosalie; Eng-King Tan
作者单位1. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; 2. Department of Neurology, Singapore General Hospital Campus, National Neuroscience Institute, Singapore, Singapore; 3. Department of Internal Medicine, National University Hospital, Singapore, Singapore; 4. Neuroscience and Behavioural Disorders, Duke-NUS Medical School, Singapore, Singapore; 5. Yong Loo Ling School of Medicine, National University of Singapore, Singapore, Singapore; 6. Department of Neuroradiology, Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore
The mitophagy-inflammasome axis: a shared pathological hub in Alzheimer’s and Parkinson’s diseases
作者Wei Long; Mengqin Yuan; Sirui Wang; Xinyue Tan; Li-Chen Gao
作者单位1. Department of Pharmacy, Phase I Clinical Trial Centre, School of Pharmaceutical Science, Hengyang Medical School, The Affiliated Changsha Central Hospital, University of South China, Changsha, China; 2. Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, China; 3. School of Life Science, Hunan University of Science and Technology, Xiangtan, China
Cholesterol nose-to-brain delivery as a possible therapeutic strategy in Huntington’s disease
作者Monica Favagrossa; Alice Passoni; Marta Valenza; Daria Di Prisco; Giulia Birolini; Michela Villa; Andrea Scolz; Laura Pasetto; Valentina Bonetto; Chiara Zuccato; Caterina Mariotti; Renzo Bagnati; Elena Cattaneo; Laura Colombo; Mario Salmona
作者单位1. Department of Molecular Biochemistry and Pharmacology, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy; 2. Department of Environmental Health Science, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy; 3. Department of Biosciences, University of Milan, Milan, Italy; 4. Istituto Nazionale Di Genetica Molecolare “Romeo Ed Enrica Invernizzi”, Milan, Italy; 5. Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy; 6. Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
Brain insulin resistance as a driver of proteinopathy in neurodegeneration: from cell-type-specific mechanisms to targeted therapeutics
作者Man Xiang; Si-Yu Cao; Xue-Heng Sun; Jing-Wen Hu; Ming-Zhe Lv; Jia-Yi Li; Wen Li
作者单位1. Laboratory of Research in Parkinson’s Disease and Related Disorders, Institute of Health Science, China Medical University, Shenyang, China; 2. Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China; 3. Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China; 4. Neural Plasticity and Repair Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
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