医学
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Proteo-metabolomic integration identifies stage-specific candidate biomarkers for Parkinson’s disease
作者Aya Galal; Ahmed Moustafa; Mohamed Salama
作者单位1. Institute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt; 2. Systems Genomics Laboratory, The American University in Cairo, Cairo, Egypt; 3. Department of Biology, The American University in Cairo, Cairo, Egypt; 4. Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland; 5. Faculty of Medicine, Mansoura University, El Mansûra, Egypt
Biological heterogeneity in Parkinson’s disease: implications for MRI-based patient stratification
作者Marta M. Pokotylo; Norbert Brüggemann; Jannik Prasuhn
作者单位1. Section of Movement Disorders, Department of Neurology, University of Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany; 2. Center for Brain, Behaviour, and Metabolism, University of Luebeck, Luebeck, Germany; 3. Institute of Neurogenetics, University of Luebeck, Luebeck, Germany; 4. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA; 5. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, USA
Matters arising: bridging predictive algorithms and clinical practice in DBS contact selection
作者Annabel van der Weide; Yarit Wiggerts; Deborah Hubers; Bart J. Keulen; Martijn G. J. de Neeling; Mariëlle J. Stam; Bernadette C. M. van Wijk; Maarten Bot; Rick Schuurman; Rob M. A. de Bie; Martijn Beudel
作者单位1. Department of Neurology, Amsterdam University Medical Center, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, Netherlands; 2. Department of Neurosurgery, Amsterdam University Medical Center, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, Netherlands; 3. Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Regional reduction of high-energy phosphorus metabolites characterizes the cerebellar subtype of multiple system atrophy
作者Jannik Prasuhn; Christina Bodemann; Britt Ebeling; Katharina Reuther; Sinja S. Großer; Jan Uter; Julia Henkel; Henrike Hanssen; Norbert Brüggemann
作者单位1. Section of Movement Disorders, Department of Neurology, University Medical Center Schleswig-Holstein, Lübeck, Germany; 2. Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; 3. Center for Brain, Behavior, and Metabolism, University of Lübeck, Lübeck, Germany; 4. Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, USA; 5. F.M. Kirby Research Center for Functional Brain Imaging, Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA
Peripheral blood transcriptomic signature is associated with cognitive impairment and freezing of gait in Parkinson’s disease: a data-driven approach
作者Reeree Lee; Mincheol Park
作者单位1. Department of Nuclear Medicine, Chung-Ang University College of Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Republic of Korea; 2. Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, USA; 3. Department of Neurology, Chung-Ang University College of Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Republic of Korea
Pesticide exposure and multidomain symptom burden in Parkinson’s disease: a longitudinal triangulation study
作者Zhengjie Yang; Shijv Shen; Saskia Preissner; Robert Preissner
作者单位1. Institute of Physiology, Charité–Universitätsmedizin Berlin, Philippstr. 12, Berlin, Germany; 2. Department of Oral and Maxillofacial Surgery, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany; 3. Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany
Oligomeric Alpha-Synuclein from neural-derived extracellular vesicles as possible biomarkers of non-motor symptoms in Parkinson’s disease
作者Mario Meloni; Cristina Agliardi; Anna Salvatore; Francesca Lea Saibene; Massimo Marano; Anna Castagna; Pietro Arcuri; Milena Zanzottera; Franca Rosa Guerini; Mario Clerici
作者单位1. Neurology Unit, Azienda Ospedaliero-Universitaria, Cagliari, Italy; 2. Laboratory of Molecular Medicine and Biotech (LAMMB), IRCCS Fondazione Don Carlo Gnocchi ETS, Milan, Italy; 3. Neurorehabilitation Unit, IRCCS Fondazione Don Carlo Gnocchi ETS, Milan, Italy; 4. Department of Medicine, Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, University Campus Bio-Medico of Rome, Rome, Italy; 5. Fondazione Policlinico Universitario Campus Bio - Medico, Rome, Italy; 6. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Dopamine-related alterations in functional brain network dynamic reconfiguration in Parkinson’s disease
作者AmirHussein Abdolalizadeh; Micha Burkhardt; Paria Jahansa; Carsten Gießing; Karsten Witt; Christiane M. Thiel
作者单位1. Biological Psychology Lab, Department of Psychology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; 2. Psychological Methods and Statistics, Department of Psychology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; 3. Mathematical Psychology, Department of Psychology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; 4. Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; 5. Department of Neurology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany
Considerations on combination therapies for disease modification in Parkinson’s
作者Rachel M. Hughes; Aleksandra Pilcicka; Trevor Klee; Fiona Ducotterd; Heather Mortiboys; Simon R. W. Stott
作者单位1. Cure Parkinson’s, London, UK; 2. Highway Pharmaceuticals, Boston, USA; 3. Alzheimer’s Research UK UCL Drug Discovery Institute, University College London, London, UK; 4. Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK
Lewy pathology largely absent in prefrontal cortices of Parkinson’s disease patients undergoing deep brain stimulation
作者Ariela S. Buxbaum Grice; Brian H. Kopell; Klaudia F. Laborc; Anina N. Lund; Renata Gonzalez Chong; Meredith Spadaccia; Gerard Ona; Girish Nadkarni; John F. Crary; Alexander W. Charney; Noam D. Beckmann
作者单位1. Icahn School of Medicine at Mount Sinai, New York, USA; 2. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA; 3. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, USA; 4. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA; 5. Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, USA; 6. Center for Neuromodulation, Icahn School of Medicine at Mount Sinai, New York, USA; 7. Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, USA; 8. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA; 9. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA; 10. Department of Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, New York, USA; 11. Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, USA; 12. Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, USA; 13. The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, USA; 14. Department of Medicine, Division of Data Driven and Digital Medicine (D3M), Icahn School of Medicine at Mount Sinai, New York, USA
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