医学
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14 篇有效样本 · 按发表日期由新到旧排列
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Cortical thickness changes precede high levels of amyloid by at least 7 years
作者James M. Roe; William J. Jagust; Susan M. Landau; Theresa M. Harrison; Håkon Grydeland; Maksim Slivka; José-Luis Alatorre-Warren; Pablo F. Garrido; Øystein Sørensen; Edvard O. S. Grødem; Tyler J. Ward; Esten H. Leonardsen; Alice Murphy; JiaQie Lee; Tormod Fladby; Atle Bjørnerud; Kristine B. Walhovd; Anders M. Fjell; Didac Vidal-Piñeiro; Yunpeng Wang
作者单位1. Center for Lifespan Changes in Brain and Cognition (LCBC), Department of Psychology, University of Oslo, Oslo, Norway; 2. Computational Radiology and Artificial Intelligence, Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; 3. Department of Neuroscience, University of California, Berkeley, Berkeley, USA; 4. Centre for Precision Psychiatry, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 5. Department of Neurology, Akershus University Hospital, Lørenskog, Norway; 6. Institute for Clinical Medicine, University of Oslo, Oslo, Norway
Dendritic translation and neuroproteasome-mediated degradation of endogenous tau revealed by STARFISH
作者Kalin D. Konrad-Vicario; Victoria Paradise; Lara Y. Demir; Chi Nguyen; Christopher D. Makinson; Zhao Ming; Kapil V. Ramachandran
作者单位1. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, USA; 2. Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, USA; 3. Department of Neuroscience, Vagelos College of Physicians and Surgeons, Columbia University, New York, USA; 4. Synbio Technologies, Monmouth Junction, USA
A suite of engineered mice for interrogating psychedelic drug actions
作者Yi-Ting Chiu; Ariel Y. Deutch; Wei Wang; Gavin P. Schmitz; Karen Lu Huang; D. Dewran Kocak; Pierre Llorach; Kasey R. Bowyer; Bei Liu; Noah Sciaky; Kunjie Hua; Chongguang Chen; Sarah E. Mott; Jesse Niehaus; Jeffrey F. DiBerto; Justin English; Jessica J. Walsh; Grégory Scherrer; Melissa A. Herman; Zhuhao Wu; William C. Wetsel; Bryan L. Roth
作者单位1. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, USA; 2. Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, USA; 3. Department of Pharmacology, Vanderbilt University Medical Center, Nashville, USA; 4. Helen and Robert Appel Alzheimer’s Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, USA; 5. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, USA; 6. UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, USA; 7. Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA; 8. Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, USA; 9. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, USA; 10. Department of Cell Biology, Duke University Medical Center, Durham, USA; 11. Department of Neurobiology, Duke University Medical Center, Durham, USA; 12. Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, USA
Comparative insights into insula structure and function
作者Joey A. Charbonneau; Sarah B. Carp; Jeffrey L. Bennett; Savannah M. Maw; Gilda Moadab; John P. Christianson; Mark G. Baxter; Eliza Bliss-Moreau
作者单位1. National Biomedical Research Institute, University of California Davis, Davis, USA; 2. Neuroscience Graduate Program, University of California Davis, Davis, USA; 3. Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, USA; 4. The MIND Institute, University of California Davis School of Medicine, Sacramento, USA; 5. Department of Psychology, University of California Davis, Davis, USA; 6. Department of Psychology and Neuroscience, Boston College, Chestnut Hill, USA; 7. Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, USA
Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells
作者Zhihao Zheng; Changjoo Park; Eric W. Hammerschmith; Ran Lu; Szi-Chieh Yu; Marissa Sorek; Ben Silverman; Chris S. Jordan; Amy R. Sterling; William M. Silversmith; Philipp Schlegel; Gregory S. X. E. Jefferis; Forrest Collman; H. Sebastian Seung; David W. Tank
作者单位1. Princeton Neuroscience Institute, Princeton University, Princeton, USA; 2. Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK; 3. Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK; 4. Allen Institute for Brain Science, Seattle, USA; 5. Computer Science Department, Princeton University, Princeton, USA; 6. Bezos Center for Neural Circuit Dynamics, Princeton University, Princeton, USA; 7. Department of Molecular Biology, Princeton University, Princeton, USA
Norepinephrine and dopamine sensor crosstalk depends on local innervation density
作者Ricardo C. López; Natalie Noble; Özge D. Özçete; Leonardo Silenzi; Xintong Cai; Gillian E. Handy; Jonathan W. Andersen; Tommaso Patriarchi; Yulong Li; Pascal S. Kaeser
作者单位1. Department of Neurobiology, Harvard Medical School, Boston, USA; 2. Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland; 3. Neuroscience Center Zürich, ETH and University of Zürich, Zürich, Switzerland; 4. State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China
The compositionality continuum as a principle for studying the neural basis of intelligence
作者Reidar Riveland; Alexandre Pouget; Laura Driscoll
作者单位1. Gatsby Computational Neuroscience Unit, University College London, London, UK; 2. Department of Basic Neuroscience, University of Geneva, Geneva, Switzerland; 3. Allen Institute for Neural Dynamics, Allen Institute, Seattle, USA; 4. Department of Neurobiology & Biophysics, University of Washington, Seattle, USA
A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes
作者Julien Klimmt; Carolina Cardoso Gonçalves; Jessica Valentina Montgomery; Stephan A. Müller; Merle Bublitz; Severin Filser; Lars Paeger; Brigitte Nuscher; Angelika Dannert; Sigrun Roeber; Veronica Pravata; Martina Schifferer; Joshua J. Shrouder; Nathalie Schulz; Judit González-Gallego; Silvia Cappello; Thomas Misgeld; Nikolaus Plesnila; Eduardo Beltrán; Jochen Herms; Elena De Domenico; Marc D. Beyer; Joachim L. Schultze; Christian Haass; Stefan F. Lichtenthaler; Caterina Carraro; Dominik Paquet
作者单位1. Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany; 2. Graduate School of Systemic Neuroscience (GSN), LMU Munich, Munich, Germany; 3. Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; 4. German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; 5. Neuroproteomics, School of Medicine and Health, TUM University Hospital, Technical University of Munich, Munich, Germany; 6. Institute of Neuropathology, LMU Medizin, LMU Munich, Munich, Germany; 7. Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany; 8. Chair of Physiological Genomics, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany; 9. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; 10. Max-Planck-Institute of Psychiatry, Munich, Germany; 11. Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany; 12. Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany; 13. Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany; 14. PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn and West German Genome Center, Bonn, Germany; 15. Immunogenomics & Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; 16. Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany
Developing mouse inhibitory neuron single-cell transcriptomes reveal distinct modes of cell-type diversification
作者Minhui Liu; Facundo Ferrero Restelli; Elia Micoli; Giulia Barbiera; Rani Moors; Evelien Nouboers; Malou Reverendo; Jessica Xinyun Du; Hannah Bertels; Dimitris Konstantopoulos; Keimpe Wierda; Aya Takeoka; Giordano Lippi; Lynette Lim
作者单位1. VIB-KU Leuven Center for Neuroscience, Leuven, Belgium; 2. Department of Neurosciences, Katholieke Universiteit (KU) Leuven, Leuven, Belgium; 3. Genevia Technologies Oy, Tampere, Finland; 4. Department of Neuroscience, Scripps Research Institute, La Jolla, USA; 5. RIKEN Center for Brain Science, Saitama, Japan
Probing inter-areal computations with a two-photon holographic mesoscope
作者Lamiae Abdeladim; Uday K. Jagadisan; Hyeyoung Shin; Mora B. Ogando; Hillel Adesnik
作者单位1. Department of Neuroscience, University of California, Berkeley, USA; 2. Department of Molecular and Cell Biology, University of California, Berkeley, USA; 3. School of Biological Sciences, Seoul National University, Seoul, Republic of Korea; 4. The Helen Wills Neuroscience Institute, University of California, Berkeley, USA
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