NATURE GENETICS

作者Valeriya Malysheva; Helen Ray-Jones; Nora Lakes; Rachel A. Brown; Tareian A. Cazares; Owen Clay; David E. Ohayon; Pavel Artemov; Joseph A. Wayman; Zi F. Yang; Monica Della Rosa; Carmen Petitjean; Clarissa Booth; Joseph I. J. Ellaway; Jenna R. Barnes; Andrew W. Dangel; Ankita Saini; William R. Orchard; Xiaoting Chen; Sreeja Parameswaran; Frances Burden; Mattia Frontini; Takashi Nagano; Peter Fraser; Stefan Schoenfelder; Matthew T. Weirauch; Leah C. Kottyan; David F. Smith; Nick Powell; Jill M. Weimer; Eugene M. Oltz; Chris Wallace; Emily R. Miraldi; Stephen N. Waggoner; Mikhail Spivakov

作者单位1. MRC Laboratory of Medical Sciences, London, UK; 2. Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK; 3. VIB, Center for Molecular Neurology, Antwerp, Belgium; 4. Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium; 5. VIB, Center for AI and Computational Biology, Leuven, Belgium; 6. Trinity Hall, University of Cambridge, Cambridge, UK; 7. Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands; 8. Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, USA; 9. Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, USA; 10. Division of Human Genetics and Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, USA; 11. Department of Microbial Infection and Immunity, The Ohio State University, Columbus, USA; 12. Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, USA; 13. Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA; 14. Eli Lilly and Company, Indianapolis, USA; 15. Division of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA; 16. Section of Pediatric Rheumatology, Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, USA; 17. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK; 18. NeoGenomics, Cambridge, UK; 19. British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; 20. Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; 21. Center for Genetics and Rare Diseases, Sanford Research, Sioux Falls, USA; 22. European Bioinformatics Institute, Hinxton, UK; 23. University of Cambridge, Cambridge, UK; 24. Cancer Research UK Cambridge Research Institute, Cambridge, UK; 25. Department of Haematology, University of Cambridge, Cambridge, UK; 26. National Health Service (NHS) Blood and Transplant, Cambridge, UK; 27. University of Kent, Canterbury, UK; 28. Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, Exeter, UK; 29. The Babraham Institute, Cambridge, UK; 30. Laboratory for Nuclear Dynamics, Institute for Protein Research, Osaka University, Osaka, Japan; 31. Institute of Medical Science, University of Tokyo, Tokyo, Japan; 32. Department of Biological Sciences, Florida State University, Tallahassee, USA; 33. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA; 34. Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA; 35. Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA; 36. Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA; 37. Department of Otolaryngology, Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, USA; 38. Divisions of Pediatric Otolaryngology and Pulmonary & Sleep Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA; 39. Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; 40. MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge Institute of Public Health, Cambridge, UK; 41. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK

作者Maya U. Sheth; Wei-Lin Qiu; X. Rosa Ma; Andreas R. Gschwind; Evelyn Jagoda; Anthony S. Tan; James Galante; Judhajeet Ray; Dulguun Amgalan; Hjörleifur Einarsson; Bram L. Gorissen; Danilo Dubocanin; Christopher S. McGinnis; Jacob Huang; Glen Munson; Kayla Brand; Ansuman T. Satpathy; Thouis R. Jones; Lars M. Steinmetz; Anshul Kundaje; Berk Ustun; Jesse M. Engreitz; Robin Andersson

作者单位1. The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, USA; 2. Department of Genetics, Stanford University School of Medicine, Stanford, USA; 3. Basic Sciences and Engineering Initiative, Betty Irene Moore Children’s Heart Center, Lucile Packard Children’s Hospital, Stanford, USA; 4. Department of Bioengineering, Stanford University, Stanford, USA; 5. Department of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark; 6. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, USA; 7. Department of Pathology, Stanford University, Stanford, USA; 8. Parker Institute for Cancer Immunotherapy, San Francisco, USA; 9. Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany; 10. Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, USA; 11. Department of Computer Science, Stanford University, Stanford, USA; 12. Halıcıoğlu Data Science Institute and Department of Computer Science and Engineering, University of California San Diego, San Diego, USA; 13. Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, USA; 14. Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, USA

作者Valentina Baderna; Guido Barzaghi; Rozemarijn Kleinendorst; Kasit Chatsirisupachai; Laura Moniot-Perron; Colm Doyle; Meike Schopp; Tino Hochepied; Claude Libert; Duncan T. Odom; Judith B. Zaugg; Arnaud R. Krebs

作者单位1. Genome Biology Unit, EMBL Heidelberg, Heidelberg, Germany; 2. Faculty of Biosciences, Collaboration for Joint PhD Degree between EMBL and Heidelberg University, Heidelberg, Germany; 3. Institut Imagine, Paris, France; 4. Division of Precision Medicine, NYU Grossman School of Medicine, New York City, USA; 5. Division of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 6. German Cancer Research Center (DKFZ), Division of Regulatory Genomics and Cancer Evolution, Heidelberg, Germany; 7. VIB Center for Inflammation Research, Ghent, Belgium; 8. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; 9. Structural and Computational Biology Unit, EMBL Heidelberg, Heidelberg, Germany; 10. Department of Biomedicine, University of Basel, Basel, Switzerland

作者Nicola Calonaci; Eriseld Krasniqi; Daniel Colic; Stefano Scalera; Giorgia Gandolfi; Salvatore Milite; Konstantin Bräutigam; Andrea Sottoriva; Trevor A. Graham; Leonardo Egidi; Biagio Ricciuti; Marcello Maugeri-Saccà; Giulio Caravagna

作者单位1. Department of Mathematics, Informatics and Geosciences, University of Trieste, Trieste, Italy; 2. Phase IV Clinical Studies Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy; 3. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain; 4. Clinical Trial Center, Biostatistics and Bioinformatics Division, IRCCS Regina Elena National Cancer Institute, Rome, Italy; 5. Computational Biology Research Centre, Human Technopole, Milan, Italy; 6. Centre for Evolution and Cancer, Institute of Cancer Research, London, UK; 7. Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland; 8. Department of Economics, Business, Mathematics, and Statistics ‘Bruno de Finetti’, University of Trieste, Trieste, Italy; 9. Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, USA; 10. Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy; 11. Area Science Park, Trieste, Italy

作者Jonathan Levinsohn; Samuel Grindel; Bernhard Dumoulin; Amin Abedini; Carolina Conte; Aria Zheyuan Huang; Rena Levin-Klein; Boaz Weisz; Grace Rabinowitz; Andi M. Bergeson; Eunji Ha; Konstantin A. Klötzer; Nancy Zhang; Paul Titchenell; Mingyao Li; Joo-Seop Park; Juan Pablo Arroyo; Laura S. Finn; Kotaro Sasaki; Pazit Beckerman; Oren Pleniceanu; Paola Romagnani; Alex J. Hughes; Katalin Susztak

作者单位1. Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA; 2. Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA; 3. Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA; 4. Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA; 5. Department of Pediatrics, Division of Nephrology, Children’s Hospital of Philadelphia, Philadelphia, USA; 6. Department of Bioengineering, University of Pennsylvania, Philadelphia, USA; 7. Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, USA; 8. Nephrology and Dialysis Unit, Meyer Children’s Hospital IRCCS, Florence, Italy; 9. Department of Biomedical, Experimental and Clinical Sciences ‘Mario Serio’, University of Florence, Florence, Italy; 10. Kidney Research Lab, Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Aviv, Israel; 11. Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel; 12. Department of Obstetrics and Gynecology, Fetal Medicine Unit, Sheba Medical Center, Ramat Gan, Israel; 13. Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, USA; 14. Department of Physiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA; 15. Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA; 16. Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA; 17. Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA; 18. Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, USA; 19. Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, USA; 20. Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, USA