Nature Aging

作者Arturo D’Angelo; Daniel Franco-Barranco; Marco Musy; Juan Manuel Duran; James Sharpe; Nicholas Stroustrup; Ignacio Arganda Carreras; Elvan Böke

作者单位1. Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain; 2. MRC Laboratory of Molecular Biology, Cambridge, UK; 3. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK; 4. Donostia International Physics Center, San Sebastian, Spain; 5. European Molecular Biology Laboratory (EMBL-Barcelona), Barcelona, Spain; 6. Elisava, Barcelona School of Design and Engineering (UVic-UCC), Barcelona, Spain; 7. Barcelona Collaboratorium for Modelling and Predictive Biology, Barcelona, Spain; 8. ICREA, Barcelona, Spain; 9. Universitat Pompeu Fabra, Barcelona, Spain; 10. Department of Computer Science and Artificial Intelligence, University of the Basque Country (UPV/EHU), San Sebastian, Spain; 11. IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; 12. Biofisika Institute (CSIC-UPV/EHU), Leioa, Spain

作者Ruixuan Wang; Tahmineh Tabrizian; Donghai Wang; Jeb English; Anita Ayer; Maya Gal; Weng-Lang Yang; Zhiping Wu; Kai Mao; Ardijana Novaj; Xusheng Zhang; Indranil Basu; Nils P. Brodin; Wade Koba; Deepak Saxena; Jiahn Choi; Leonard H. Augenlicht; Aaron Ericsson; Evripidis Gavathiotis; Chandan Guha; Derek M. Huffman

作者单位1. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, USA; 2. Institute for Geroscience, Albert Einstein College of Medicine, Bronx, USA; 3. Department of Medicine, Albert Einstein College of Medicine, Bronx, USA; 4. Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, USA; 5. Department of Computational Genomics Core Facility, Albert Einstein College of Medicine, Bronx, USA; 6. Department of Radiology, Albert Einstein College of Medicine, Bronx, USA; 7. New York University College of Dentistry, New York, USA; 8. Montefiore-Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, USA; 9. Department of Cell Biology, Albert Einstein College of Medicine, Bronx, USA; 10. Department of Oncology, Albert Einstein College of Medicine, Bronx, USA; 11. Department of Veterinary Pathobiology, University of Missouri Metagenomics Research Center, University of Missouri, Columbia, USA; 12. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, USA; 13. Department of Pathology, Albert Einstein College of Medicine, Bronx, USA; 14. Department of Urology, Albert Einstein College of Medicine, Bronx, USA; 15. Cancer Dormancy Institute (CDI), Albert Einstein College of Medicine, Bronx, USA

作者Aidan R. Cole; Raquel Buj; Apoorva Uboveja; Evan Levasseur; Alexander Tom; Hui Wang; Katarzyna M. Kedziora; Adam Chatoff; Andrea Andress Huacachino; Mariola M. Marcinkiewicz; Amandine Amalric; Baixue Yang; Naveen Kumar Tangudu; Emily Noonan; Jeff Danielson; Miho Naruse; Amal Taher Elhaw; Sierra White; Danyang Li; Callen T. Wallace; Frederick Keeney; Felicia Lazure; Esther Elishaev; Lauren Borho; Hope A. Townsend; Robin D. Dowell; Aaron Clauset; Dorota E. Jazwinska; Matthew S. Laird; Huda Atiya; Denarda Dangaj; Lan G. Coffman; George Tseng; Steffi Oesterreich; Andrew Kossenkov; Qin Liu; Ana P. Gomes; Aditi U. Gurkar; Francisco J. Schopfer; Francesmary Modugno; Simon C. Watkins; Ioannis K. Zervantonakis; Benjamin G. Bitler; Wayne Stallaert; Nadine Hempel; Nathaniel W. Snyder; Katherine M. Aird

作者单位1. Molecular and Cellular Oncogenesis Program, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, USA; 2. Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, USA; 3. Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, USA; 4. Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, USA; 5. Tsinghua University School of Medicine, Beijing, People’s Republic of China; 6. Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, USA; 7. Department of Biostatistics, University of Pittsburgh, Pittsburgh, USA; 8. Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA; 9. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA; 10. Department of Obstetrics, Gynecology and Reproductive Sciences and Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA; 11. BioFrontiers Institute, University of Colorado Boulder, Boulder, USA; 12. Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, USA; 13. Department of Computer Science, University of Colorado Boulder, Boulder, USA; 14. Santa Fe Institute, Santa Fe, USA; 15. Department of Bioengineering and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA; 16. Division of Malignant Hematology & Medical Oncology, Department of Medicine, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, USA; 17. Ludwig Institute for Cancer Research, University of Lausanne (UNIL), Lausanne, Switzerland; 18. Genome Regulation and Cell Signaling Program, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, USA; 19. Aging Institute of UPMC and the Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA; 20. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, USA; 21. Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute (VMI); Pittsburgh Liver Research Center (PLRC); and Center for Immunometabolism, University of Pittsburgh School of Medicine, Pittsburgh, USA; 22. Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, USA; 23. Department of Computational and Systems Biology and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA

作者Andrew G. Breithaupt; Michael Weiner; Alice Tang; Katherine L. Possin; Marina Sirota; James Lah; Allan I. Levey; Pascal Van Hentenryck; Reza Zandehshahvar; Marilu Luisa Gorno-Tempini; Joseph Giorgio; Jingshen Wang; Andreas M. Rauschecker; Howard J. Rosen; Rachel L. Nosheny; Bruce L. Miller; Pedro Pinheiro-Chagas

作者单位1. Goizueta Brain Health Institute, Emory University, Atlanta, USA; 2. Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, USA; 3. School of Medicine, University of California, San Francisco, San Francisco, USA; 4. Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, USA; 5. Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, USA; 6. Department of Neurology, Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, USA; 7. NSF AI Institute for Advances in Optimization (AI4OPT), Georgia Institute of Technology, Atlanta, USA; 8. H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, USA; 9. Department of Neuroscience, University of California, Berkeley, Berkeley, USA; 10. Division of Biostatistics, University of California, Berkeley, Berkeley, USA; 11. Center for Intelligent Imaging (ci2), Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, USA; 12. Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, USA

作者Shiyi Yu; Chunling Chen; Jing Feng; Qinming Li; Shuo Chen; Ruijie Zeng; Dongling Luo; Wentao Huang; Kexin Zhang; Yuying Ma; Lijun Zhang; Meijun Meng; Yanjun Wu; Dong Chen; Qizhou Lian; Felix W. Leung; Chusi Wang; Weihong Sha; Hao Chen

作者单位1. Department of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China; 2. HKUMed Laboratory of Cellular Therapeutics and State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; 3. State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; 4. Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China; 5. The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; 6. Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; 7. Department of Liver Transplantation Center and Institute of Organ Transplantation, West China Hospital, Sichuan University, Chengdu, China; 8. School of Medicine, South China University of Technology, Guangzhou, China; 9. Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, China; 10. David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA; 11. Sepulveda Ambulatory Care Center, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, USA; 12. Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

作者Janko Ž. Nikolich; Matthew T. Wolf; Rebecca R. Pompano; Katharina Maisel

作者单位1. Department of Basic Medical Sciences, College of Medicine-Phoenix, University of Arizona, Phoenix, USA; 2. Aegis Center of Excellence in Immunity and Inflammation, College of Medicine-Phoenix, University of Arizona, Phoenix, USA; 3. Cancer Biomaterials Engineering Section, Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, USA; 4. Department of Chemistry and Biomedical Engineering, University of Virginia, Charlottesville, USA; 5. Fischell Department of Bioengineering, Clark School of Engineering, University of Maryland, College Park, USA; 6. R.E. Fischell Institute of Biomedical Devices, Clark School of Engineering, University of Maryland, College Park, USA

作者Neil Carleton; Alexander Chih-Chieh Chang; Sanghoon Lee; Ruxuan Li; Jian Zou; Daniel D. Brown; Jagmohan Hooda; Jian Chen; Rahul Kumar; Linda R. Klei; Lora H. Rigatti; Joseph Newsome; Dixcy Jaba Sheeba John Mary; Jennifer M. Atkinson; Raymond E. West; Thomas D. Nolin; Patrick J. Oberly; Ziyu Huang; Donald Poirier; Emilia J. Diego; Peter C. Lucas; George C. Tseng; Michael T. Lotze; Priscilla F. McAuliffe; Ioannis K. Zervantonakis; Steffi Oesterreich; Adrian V. Lee

作者单位1. Women’s Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, USA; 2. Department of Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, USA; 3. Department of Statistics, School of Public Health, Chongqing Medical University, Chongqing, China; 4. Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, USA; 5. Institute for Precision Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA; 6. Division of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, USA; 7. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA; 8. Small Molecule Biomarker Core, University of Pittsburgh School of Pharmacy, Pittsburgh, USA; 9. UPMC Hillman Cancer Center Biostatistics Facility, Pittsburgh, USA; 10. Laboratory of Medicinal Chemistry, CHU de Québec, Research Centre Université Laval, Quebec City, Canada; 11. Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, USA; 12. Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, USA; 13. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, USA; 14. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, USA

作者Mariah F. Calubag; Ismail Ademi; Cara L. Green; Dulmalika N. H. Manchanayake; Hashan S. M. Jayarathne; Ryan N. Marshall; Sandra M. Le; Penelope Lialios; Lucia E. Breuer; Shoshana Yakar; Reji Babygirija; Michelle M. Sonsalla; Isaac Grunow; Chung-Yang Yeh; Yang Liu; Bailey A. Knopf; Sarah Yandell; Charles I. Opara; William A. Ricke; Teresa T. Liu; Mark P. Keller; Alan D. Attie; Marianna Sadagurski; Dudley W. Lamming

作者单位1. Department of Medicine, University of Wisconsin–Madison, Madison, USA; 2. William S. Middleton Memorial Veterans Hospital, Madison, USA; 3. Graduate Program in Cellular and Molecular Biology, University of Wisconsin–Madison, Madison, USA; 4. Department for Health, University of Bath, Bath, UK; 5. Department of Biological Sciences, Wayne State University, Detroit, USA; 6. Institute of Environmental Health Sciences, Integrative Biosciences Center, Wayne State University, Detroit, USA; 7. New York University College of Dentistry, New York, USA; 8. Comparative Biomedical Sciences Graduate Program, University of Wisconsin–Madison, Madison, USA; 9. Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin–Madison, Madison, USA; 10. Department of Biochemistry, University of Wisconsin–Madison, Madison, USA; 11. George M. O’Brien Center of Research Excellence, Department of Urology, University of Wisconsin, Madison, USA; 12. Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging, Madison, USA; 13. Department of Pharmaceutical Sciences, St. John Fisher University, Rochester, USA; 14. University of Wisconsin–Madison Comprehensive Diabetes Center, Madison, USA; 15. University of Wisconsin Carbone Comprehensive Cancer Center, Madison, USA

作者Spiros Palikyras; Vassiliki Varamogiani-Mamatsi; Yajie Zhu; Athanasia Mizi; Shyam Ramasamy; Jonas Viken Grini; Isabel Liebermann; Athanasia Stavropoulou; Andrés Penagos Puig; Tuba Sena Ogurlu-Tank; Konstantinos Kydonakis; Ioanna Papadionysiou; Deniz Bartsch; Yulia Kargapolova; Natalia Rosalia Morero; Konstantinos Sofiadis; Christoforos Nikolaou; Franziska Kundel; Leo Kurian; Jan Ellenberg; A. Marieke Oudelaar; Mariano Barbieri; Kai Sandvold Beckwith; Argyris Papantonis

作者单位1. Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany; 2. Indivumed Therapeutics, Hamburg, Germany; 3. Genome Organization and Regulation, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany; 4. Department of Biomedical Laboratory Science, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, Norway; 5. Institute of Bioinnovation, Biomedical Sciences Research Center ‘Alexander Fleming’, Vari, Greece; 6. Unit of Molecular Genetics, University of Patras Medical School, Patras, Greece; 7. Center for Molecular Medicine Cologne, Faculty of Medicine Cologne, Cologne, Germany; 8. DISCO Pharmaceuticals GmbH, Cologne, Germany; 9. University Medical Center Mainz, Mainz, Germany; 10. Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany; 11. Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands; 12. Cardiopulmonary Institute (CPI), Goethe University of Frankfurt, Frankfurt am Main, Germany; 13. Institute for Cardiovascular Physiology, Goethe University of Frankfurt, Frankfurt am Main, Germany; 14. Center for Cancer Genome Dynamics Göttingen, Göttingen, Germany

作者Ronald A. DePinho

作者单位1. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, USA