医学
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15 篇有效样本 · 按发表日期由新到旧排列
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Tumor-infiltrating B cells evolve towards interferon-rich trajectories aligned with immunotherapy in melanoma
作者Katie Stoker; Roman Laddach; Lucy Booth; Silvia Crescioli; Oscar Maiques; Rebecca Adams; Jitesh Chauhan; Alexander Stewart; Dinethri Patel; Amanda Fitzpatrick; Yin Wu; Jenny L. C. Geh; Omar Salem; Alastair D MacKenzie Ross; Hawys Lloyd-Hughes; Sean Whittaker; Joseph Ng; Franca Fraternali; David Kipling; Deborah K. Dunn-Walters; Katie E. Lacy; Thomas J. Tull; Sophia Tsoka; Sophia N. Karagiannis
作者单位1. St. John’s Institute of Dermatology, School of Basic and Medical Biosciences &, KHP Centre for Translational Medicine, Guy’s Hospital, King’s College London, London, UK; 2. Department of Informatics, Faculty of Natural, Mathematical and Engineering Sciences, King’s College London, London, UK; 3. Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, London, UK; 4. School of Biosciences and Medicine, University of Surrey, Guildford, UK; 5. Department of Medical Oncology, Guy’s and St Thomas’ Hospitals, London, UK; 6. Breast Cancer Now Research Unit, School of Cancer and Pharmaceutical Sciences, King’s College London, London, UK; 7. Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King’s College London, London, UK; 8. St John’s Institute of Dermatology, Guy’s, and St. Thomas’ Hospitals NHS Foundation Trust, London, UK; 9. Department of Plastic Surgery, Guy’s and St. Thomas’ Hospitals NHS Foundation Trust, London, UK; 10. Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King’s College London, London, UK; 11. Department of Structural and Molecular Biology, Division of Biosciences and Institute of Structural and Molecular Biology, University College London, London, UK; 12. Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance
作者Nils Cordes
作者单位1. OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; 2. Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany; 3. German Cancer Research Center, German Cancer Consortium, Partner Site Dresden, Heidelberg, Germany; 4. National Center for Tumor Diseases (NCT), Partner Site Dresden, German Cancer Research Center (DKFZ), Heidelberg, Germany
Transcriptional evidence of neuroendocrine cell plasticity beyond histological boundaries in lung neuroendocrine neoplasms: an in-silico analysis suggesting a progression model
作者Giuseppe Pelosi; Mauro Papotti; Riccardo Papa; Eleonora Duregon; Maria Gemelli; Sergio Harari; Angelica Sonzogni; Alice Laffi; Tommaso De Pas; Chiara Catania; Barbara Bassani; Fiorenza Lotti; Antonino Bruno; Paola Muti; Fabrizio Bianchi
作者单位1. Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy; 2. Inter-Hospital Pathology Division, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Milan, Italy; 3. Department of Oncology, University of Turin, Turin, Italy; 4. Unit of Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Milan, Italy; 5. Department of Medical Sciences and Community Health, University of Milan, Milan, Italy; 6. Division of Pneumology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Milan, Italy; 7. Department of Pathology and Laboratory Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori, Milan, Italy; 8. Division of Medical Oncology, Humanitas Gavazzeni, Bergamo, Italy; 9. Laboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry, and Immunology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Milan, Italy; 10. Department of Biotechnology and Life Sciences, Laboratory of Immunology and General Pathology, University of Insubria, Varese, Italy; 11. Department of Biomedical, Surgical and Dental Health Sciences, University of Milan, Milan, Italy; 12. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Milan, Italy; 13. Unit of Cancer Biomarkers, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Tailored FcγR blockade enhances immune checkpoint therapy and overcomes resistance
作者Robert J. Oldham; Linda Mårtensson; Monika Semmrich; Niyaz Yoosuf; Petra Holmkvist; Lara V. Graham; Martin C. Taylor; Kirstie L. S. Cleary; Mona Yazdani; Josephine F. Buckingham; Ali Roghanian; Ingrid Karlsson; Stephen A. Beers; Ingrid Teige; Mark S. Cragg; Björn Frendéus
作者单位1. Antibody and Vaccine Group, School of Cancer Sciences, University of Southampton, Southampton, UK; 2. BioInvent, Lund, Sweden
Targeting the CAF-GDF15 axis attenuates AKT-mediated mitochondrial rewiring and chemoradiation resistance in esophageal adenocarcinoma
作者Ningbo Fan; Pinwei Deng; Zhefang Wang; Feng Ju; Lisa Raatz; Oscar Velazquez Camacho; Axel M. Hillmer; Margarete Odenthal; Phuong-Hien Nguyen; Zicheng Lyu; Felix Popp; Seung-Hun Chon; Maarten F. Bijlsma; Romy Ros; Hanneke W. M. van Laarhoven; Alexander Quaas; Jörg Wischhusen; Yue Zhao; Christiane J. Bruns
作者单位1. Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany; 2. Department of Thoracic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China; 3. Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany; 4. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany; 5. Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, Cologne, Germany; 6. Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, RDC Adore, Amsterdam, The Netherlands; 7. Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands; 8. Department of Medical Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; 9. Department for Obstetrics & Gynaecology, University Hospital Würzburg, Section for Experimental Tumor Immunology, Würzburg, Germany
Selenite modulates phenotype-dependent epithelial–mesenchymal plasticity in pancreatic ductal adenocarcinoma: integrated in vitro analyses and patient-derived ex vivo tissue-slice cultures
作者Ozan Aricak; Wenyang Shi; Carlos Fernández Moro; Mehran Ghaderi; Joakim Dillner; Jonas Fuxe; Mikael Björnstedt; Tímea Szekerczés
作者单位1. Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; 2. Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden; 3. Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
Mesenchymal stem cell-induced metabolic reprogramming of EGFR-wild-type tumor cells drives therapeutic resistance in EGFR-mutant non-small cell lung cancer
作者Hongyu Bie; Jiarui Li; Jialin Liu; Jian Zhou; Tierun Wang; Xu Guo; Jiawei Liu; Yi You; Hui Huang; Shijia Li; Wanqiao Li; Xiubao Ren; Meng Wang; Wencheng Zhang; Cihui Yan
作者单位1. Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China; 2. Tianjin’s Clinical Research Center for Cancer, Tianjin, China; 3. National Clinical Research Center for Cancer, Tianjin, China; 4. State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin, China; 5. Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China; 6. Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China; 7. Key Laboratory of Cancer Prevention and Therapy, Tianjin, China; 8. Department of Lung Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China; 9. Tianjin Lung Cancer Center, Tianjin, China
Decoding glioblastoma evolution and heterogeneity through mechanistic modeling: implications for clinical translation
作者Haowu Jiang; Wan Zhao; Hui Zhou; Rui Sun
作者单位1. Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People’s Republic of China; 2. Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People’s Republic of China; 3. Department of Respiratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (Anhui Provincial Cancer Hospital), Hefei, People’s Republic of China; 4. Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, People’s Republic of China
From paradox to target: IFN-β hijacks MEK signaling to drive a cell death-evading dormant phenotype in colorectal cancer
作者Yangyang Zhou; Haigang Geng; Yi Xu; Yanggang Hong; Bo Mei; Huanglei Wu; Xuanxuan Jin; Mengfan Ye; Yi Wang; Zan Shen; Zhigang Zheng; Zhenhua Zhu; Xiangchou Yang; Zizhen Zhang; Chunchao Zhu
作者单位1. Department of Oncology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2. Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 3. Department of Gastrointestinal Cancer Translational Research, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital, Beijing, China; 4. State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 5. The Second School of Medicine, Wenzhou Medical University, Wenzhou, China; 6. Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Beijing, China; 7. Department of Coloprotology, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China; 8. Department of Urology, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China; 9. The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China; 10. Shanghai Cancer Institute, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 11. Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 12. Department of Hematology and Medical Oncology, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
HES1 inhibition overcomes CDK4/6 inhibitor resistance by targeting cancer stemness in lung adenocarcinoma
作者Alvin Ho Kwan Cheung; Kit Yee Wong; Gordon Yuan-Ho Li; Fuda Xie; Qiuqiu Wu; Thomas Tin Ho Yuen; Pak Lam Hui; Pingmei Huang; Xiaoli Liu; Bonan Chen; Fenfen Ji; Yujuan Dong; Alfred Sze-Lok Cheng; Calvin Sze Hang Ng; Xiang Zhang; Chi Chun Wong; Jun Yu; Wei Kang; Ka-Fai To
作者单位1. Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China; 2. Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; 3. Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China; 4. School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
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