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审稿天数=录用日期-收稿日期;保留 PDF/DOI/网页源链接
Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters
作者Yong-Qiang Deng; Na-Na Zhang; Yi-Fei Zhang; Xia Zhong; Sue Xu; Hong-Ying Qiu; Tie-Cheng Wang; Hui Zhao; Chao Zhou; Shu-Long Zu; Qi Chen; Tian-Shu Cao; Qing Ye; Hang Chi; Xiang-Hui Duan; Dan-Dan Lin; Xiao-Jing Zhang; Liang-Zhi Xie; Yu-Wei Gao; Bo Ying; Cheng-Feng Qin
作者单位1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, China; 2. School of Medicine, Tsinghua University, Beijing, China; 3. Kunming University of Science and Technology, Kunming, China; 4. Suzhou Abogen Biosciences Co., Ltd, Suzhou, China; 5. Key laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, Jilin, China; 6. Beijing Protein and Antibody R&D Engineering Center, Sinocelltech Ltd, Beijing, China
EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription
作者Xiaoqing Lu; Liwei An; Guangjian Fan; Lijuan Zang; Weiyi Huang; Junjian Li; Jun Liu; Weiyu Ge; Yuwei Huang; Jingxuan Xu; Shaoqian Du; Yuan Cao; Tianhao Zhou; Huijing Yin; Li Yu; Shi Jiao; Hongxia Wang
作者单位1. State Key Laboratory of Oncogenes and Related Genes, Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2. Department of Breast Surgery, Shanxi Cancer Hospital, Chinese Academy of Medical Sciences, Taiyuan, Shanxi, China; 3. Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Tongji University Cancer Center, School of Medicine, Tongji University, Shanghai, China; 4. Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 5. Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 6. State Key Laboratory of Membrane Biology, Tsinghua-Peking University Joint Center for Life Sciences, School of Life Science, Tsinghua University, Beijing, China; 7. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex
作者Gaoxingyu Huang; Xiechao Zhan; Chao Zeng; Xuechen Zhu; Ke Liang; Yanyu Zhao; Pan Wang; Qifan Wang; Qiang Zhou; Qinghua Tao; Minhao Liu; Jianlin Lei; Chuangye Yan; Yigong Shi
作者单位1. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China; 2. Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China; 3. Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China; 4. Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; 5. Tsinghua University-Peking University Joint Center for Life Sciences; School of Life Sciences, Tsinghua University, Beijing, China
Rapid development of an updated mRNA vaccine against the SARS-CoV-2 Omicron variant
作者Na-Na Zhang; Rong-Rong Zhang; Yi-Fei Zhang; Kai Ji; Xiao-Chuan Xiong; Qian-Shan Qin; Peng Gao; Xi-Shan Lu; Hang-Yu Zhou; Hai-Feng Song; Bo Ying; Cheng-Feng Qin
作者单位1. Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China; 2. School of Medicine, Tsinghua University, Beijing, China; 3. Kunming University of Science and Technology, Kunming, China; 4. Suzhou Abogen Biosciences Co., Ltd., Suzhou, China; 5. School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China; 6. Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; 7. Research Unit of Discovery and Tracing of Natural Focus Diseases, Chinese Academy of Medical Sciences, Beijing, China
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate
作者Ao Hu; Jing-Zan Zhang; Jie Wang; Chen-Chen Li; Meng Yuan; Gang Deng; Zi-Cun Lin; Zhi-Ping Qiu; Hu-Yue Liu; Xian-Wei Wang; Peng-Cheng Wei; Xiao He; Xiaolu Zhao; Wen-Wei Qiu; Bao-Liang Song
作者单位1. The Institute for Advanced Studies, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China; 2. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China; 3. College of Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China; 4. NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai, China
Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis
作者Chao Dou; Zhaolin Long; Shoujie Li; Dan Zhou; Ying Jin; Li Zhang; Xuan Zhang; Yanhui Zheng; Lin Li; Xiaofeng Zhu; Zheng Liu; Siyu He; Weizhu Yan; Lulu Yang; Jie Xiong; Xianghui Fu; Shiqian Qi; Haiyan Ren; She Chen; Lunzhi Dai; Binju Wang; Wei Cheng
作者单位1. Division of Respiratory and Critical Care Medicine, Respiratory Infection and Intervention Laboratory of Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, China; 2. State Key Laboratory of Structural Chemistry of Solid Surface and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China; 3. National Institute of Biological Sciences, NIBS, Beijing, China; 4. College of Life Science, Sichuan University, Chengdu, China; 5. Beijing National Laboratory for Molecular Sciences (BNLMS), Beijing Key Laboratory for Magnetoelectric Materials and Devices, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant
作者Shuai Xia; Jasper Fuk-Woo Chan; Lijue Wang; Fanke Jiao; Kenn Ka-Heng Chik; Hin Chu; Qiaoshuai Lan; Wei Xu; Qian Wang; Chao Wang; Kwok-Yung Yuen; Lu Lu; Shibo Jiang
作者单位1. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China; 2. State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China; 3. Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China; 4. Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong, China; 5. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China
Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals
作者Siyuan Hou; Zongcheng Li; Ji Dong; Yun Gao; Zhilin Chang; Xiaochen Ding; Shuaili Li; Yunqiao Li; Yang Zeng; Qian Xin; Baihan Wang; Yanli Ni; Xiaowei Ning; Yuqiong Hu; Xiaoying Fan; Yu Hou; Xianlong Li; Lu Wen; Bin Zhou; Bing Liu; Fuchou Tang; Yu Lan
作者单位1. Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China; 2. State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China; 3. Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, China; 4. Beijing Advanced Innovation Center for Genomics and Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University, Beijing, China; 5. State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, China; 6. Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, China; 7. The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; 8. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China
Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates
作者Denisa Bojkova; Marek Widera; Sandra Ciesek; Mark N. Wass; Martin Michaelis; Jindrich Cinatl
作者单位1. Institute for Medical Virology, University Hospital, Goethe University, Frankfurt am Main, Germany; 2. German Center for Infection Research, DZIF, External Partner Site Frankfurt am Main, Frankfurt am Main, Germany; 3. Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine und Pharmacology, Frankfurt am Main, Germany; 4. School of Biosciences, University of Kent, Canterbury, UK; 5. Dr. Petra Joh-Forschungshaus, Frankfurt am Main, Germany
SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination
作者Pengfei Li; Yining Wang; Marla Lavrijsen; Mart M. Lamers; Annemarie C. de Vries; Robbert J. Rottier; Marco J. Bruno; Maikel P. Peppelenbosch; Bart L. Haagmans; Qiuwei Pan
作者单位1. Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; 2. Viroscience Department, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; 3. Department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands; 4. Department of Cell Biology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands
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