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12 篇有效样本 · 按发表日期由新到旧排列
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Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APP V717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator
作者Wenhui Qu; Matti Lam; Julie J. McInvale; Jason A. Mares; Sam Kwon; Nelson Humala; Aayushi Mahajan; Trang Nguyen; Kelly A. Jakubiak; Jeong-Yeon Mun; Thomas G. Tedesco; Osama Al-Dalahmah; Syed A. Hussaini; Andrew A. Sproul; Markus D. Siegelin; Philip L. De Jager; Peter Canoll; Vilas Menon; Gunnar Hargus
作者单位1. Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, New York, USA; 2. Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, New York, USA; 3. Department of Neurosurgery, Columbia University, New York, USA; 4. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, USA
Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury
作者Fari Ryan; Christian Blex; The Dung Ngo; Marcel A. Kopp; Bernhard Michalke; Vivek Venkataramani; Laura Curran; Jan M. Schwab; Klemens Ruprecht; Carolin Otto; Priya Jhelum; Antje Kroner; Samuel David
作者单位1. Centre for Research in Neuroscience, The BRAiN Program, The Research Institute of the McGill University Health Centre, Montreal, Canada; 2. Clinical and Experimental Spinal Cord Injury Research (Neuroparaplegiology), Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany; 3. Research Unit Analytical BioGeoChemistry, Helmholz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; 4. Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany; 5. Belford Center for Spinal Cord Injury and Departments of Neurology and Neurosciences, The Ohio State University, Columbus, USA; 6. Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 7. Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, USA
Annexin A11 aggregation in FTLD–TDP type C and related neurodegenerative disease proteinopathies
作者John L. Robinson; EunRan Suh; Yan Xu; Howard I. Hurtig; Lauren Elman; Corey T. McMillan; David J. Irwin; Sílvia Porta; Vivianna M. Van Deerlin; Edward B. Lee
作者单位1. Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute On Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA; 2. Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease
作者Nikita Ollen-Bittle; Shervin Pejhan; Stephen H. Pasternak; C. Dirk Keene; Qi Zhang; Shawn N. Whitehead
作者单位1. Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Canada; 2. Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, Canada; 3. Schulich School of Medicine and Dentistry, Robarts Research Institute, London, Canada; 4. Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Canada; 5. Department of Laboratory Medicine and Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, USA; 6. Department of Anatomy and Cell Biology, 454 Medical Sciences Building, The University of Western Ontario, London, Canada
Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database
作者Davis C. Woodworth; Katelynn M. Nguyen; Lorena Sordo; Kiana A. Scambray; Elizabeth Head; Claudia H. Kawas; María M. Corrada; Peter T. Nelson; S. Ahmad Sajjadi
作者单位1. Department of Neurology, University of California, Irvine, Irvine, USA; 2. Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA; 3. Department of Pathology and Laboratory Medicine, University of California, Irvine, USA; 4. Department of Neurobiology and Behavior, University of California, Irvine, USA; 5. Department of Epidemiology and Biostatistics, University of California, Irvine, USA; 6. Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, USA
Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis
作者Christina B. Schroeter; Christopher Nelke; Frauke Stascheit; Niklas Huntemann; Corinna Preusse; Vera Dobelmann; Lukas Theissen; Marc Pawlitzki; Saskia Räuber; Alice Willison; Anna Vogelsang; Adela Della Marina; Hans-Peter Hartung; Nico Melzer; Felix F. Konen; Thomas Skripuletz; Andreas Hentschel; Simone König; Michaela Schweizer; Kai Stühler; Gereon Poschmann; Andreas Roos; Werner Stenzel; Andreas Meisel; Sven G. Meuth; Tobias Ruck
作者单位1. Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany; 2. Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany; 3. Department of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany; 4. Department of Neuropaediatrics, Neuromuscular Centre, Universitätsmedizin Essen, Essen, Germany; 5. Brain and Mind Center, University of Sydney, Sydney, Australia; 6. Department of Neurology, Palacky University Olomouc, Olomouc, Czech Republic; 7. Department of Neurology, Hannover Medical School, Hannover, Germany; 8. Leibniz-Institut Für Analytische Wissenschaften – ISAS - E.V, Dortmund, Germany; 9. Core Unit Proteomics, Interdisciplinary Center for Clinical Research, Medical Faculty, University of Münster, Münster, Germany; 10. Electron Microscopy Unit, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 11. Institute for Molecular Medicine, Proteome Research, University Hospital and Medical Faculty, Heinrich Heine University, Duesseldorf, Germany; 12. Molecular Proteomics Laboratory, Biological Medical Research Center, Heinrich Heine University, Duesseldorf, Germany
Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
作者Zachary Hoglund; Nancy Ruiz-Uribe; Eric del Sastre; Benjamin Woost; Elizabeth Bader; Joshua Bailey; Bradley T. Hyman; Theodore Zwang; Rachel E. Bennett
作者单位1. Department of Neurology, Massachusetts General Hospital, Charlestown, USA; 2. Harvard Medical School, Boston, USA
Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
作者Justin K. Mielke; Mikael Klingeborn; Eric P. Schultz; Erin L. Markham; Emily D. Reese; Parvez Alam; Ian R. Mackenzie; Cindy V. Ly; Byron Caughey; Neil R. Cashman; Moses J. Leavens
作者单位1. Department of Biomedical Sciences, McLaughlin Research Institute, Great Falls, USA; 2. Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, USA; 3. Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, USA; 4. Departments of Pathology and Medicine, University of British Columbia, Vancouver, Canada; 5. Department of Neurology, Washington University, Saint Louis, USA
Early and selective localization of tau filaments to glutamatergic subcellular domains within the human anterodorsal thalamus
作者Barbara Sárkány; Csaba Dávid; Tibor Hortobágyi; Péter Gombás; Peter Somogyi; László Acsády; Tim J. Viney
作者单位1. Department of Pharmacology, University of Oxford, Oxford, UK; 2. Lendület Laboratory of Thalamus Research, Institute of Experimental Medicine, Budapest, Hungary; 3. Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary; 4. Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; 5. Department of Pathology, Szt. Borbála Hospital, Tatabánya, Hungary
Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer’s disease
作者Feng Gao; Mengguo Zhang; Qiong Wang; Ming Ni; Chang Liu; Kexue Deng; Qiang Xie; Shicung Wang; Jiong Shi; Yong Shen
作者单位1. Department of Neurology, Institute On Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; 2. Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; 3. Department of Nuclear Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; 4. Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; 5. Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei, China
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