EMBO Molecular Medicine

AuthorsLise Brault; Edwige Voisset; Mathieu Desaunay; Antonia Boudet; Paraskevi Kousteridou; Sébastien Letard; Nadine Carbuccia; Armelle Goubard; Rémy Castellano; Yves Collette; Julien Vernerey; Isabelle Vigon; Jean-Max Pasquet; Patrice Dubreuil; Sophie Lopez; Paulo De Sepulveda

Affiliations1. Aix Marseille University, INSERM, CNRS, Institut Paoli-Calmettes, CRCM-Cancer Research Center of Marseille, Marseille, France; 2. Signaling, Hematopoiesis and Mechanism of Oncogenesis Laboratory, Marseille, France; 3. CRCM’s Integrative Bioinformatics platform, Marseille, France; 4. TrGET preclinical facility, CRCM, Marseille, France; 5. Member of Institut Carnot OPALE (Organization for Partnerships in Leukemia), Paris, France; 6. INSERM U1312, BRIC, Université de Bordeaux, Bordeaux, France

AuthorsBenjamin Hunter; Yunwei Zhang; Dylan Harney; Holly McEwen; Yen Chin Koay; Michael Pan; Cassandra Malecki; Jasmine Khor; Robert D Hume; Giovanni Guglielmi; Alicia Walker; Shashwati Dutta; Vijay Rajagopal; Anthony Don; Mark Larance; John F O’Sullivan; Jean Y H Yang; Sean Lal

Affiliations1. Precision Cardiovascular Laboratory, The University of Sydney, Sydney, Australia; 2. Charles Perkins Centre, The University of Sydney, Sydney, Australia; 3. School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; 4. School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Sydney, Australia; 5. Sydney Precision Data Science Centre, Faculty of Science, The University of Sydney, Sydney, Australia; 6. School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, Australia; 7. School of Mathematics and Statistics, The University of Melbourne, Parkville, Australia; 8. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems, The University of Melbourne, Parkville, VIC, Australia; 9. Centre for Heart Failure and Diseases of the Aorta, The Baird Institute for Applied Heart and Lung Surgical Research, Sydney, Australia; 10. Department of Biomedical Engineering, School of Chemical and Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Parkville, Australia; 11. School of Mathematics, University of Birmingham, Birmingham, UK; 12. Baker Department of Cardiometabolic Health, Faculty of Medicine, Dentistry, and Health Sciences, The University of Melbourne, Parkville, Australia; 13. Graeme Clark Institute of Biomedical Engineering, The University of Melbourne, Parkville, Australia; 14. Central Clinical School, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; 15. Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, Australia; 16. Faculty of Medicine, TU Dresden, Dresden, Germany

AuthorsSjoerd Viktor Beentjes; Artur Miralles Méharon; Julia Kaczmarczyk; Amanda Cassar; Gemma Louise Samms; Nima S Hejazi; Ava Khamseh; Chris P Ponting

Affiliations1. School of Mathematics and Maxwell Institute for Mathematical Sciences, University of Edinburgh, Edinburgh, UK; 2. MRC Human Genetics Unit, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK; 3. Division of Biostatistics, University of California, Berkeley, USA; 4. School of Informatics, University of Edinburgh, Edinburgh, UK; 5. Harvard T.H. Chan School of Public Health, Department of Biostatistics, Boston, USA

AuthorsRosalie Matico; Karolien Grauwen; Dhruv Chauhan; Xiaodi Yu; Irini Abdiaj; Suraj Adhikary; Ine Adriaensen; Garcia Molina Aranzazu; Jesus Alcázar; Michela Bassi; Ellen Brisse; Santiago Cañellas; Shubhra Chaudhuri; Francisca Delgado; Alejandro Diéguez-Vázquez; Marc Du Jardin; Victoria Eastham; Michael Finley; Tom Jacobs; Ken Keustermans; Robert Kuhn; Josep Llaveria; Jos Leenaerts; Maria Lourdes Linares; Maria Luz Martín; Rosa Martín-Pérez; Carlos Martínez; Robyn Miller; Frances M Muñoz; Michael E Muratore; Amber Nooyens; Laura Perez-Benito; Mathieu Perrier; Beth Pietrak; Jef Serré; Sujata Sharma; Marijke Somers; Javier Suarez; Gary Tresadern; Andres A Trabanco; Dries Van den Bulck; Michiel Van Gool; Filip Van Hauwermeiren; Teena Varghese; Juan Antonio Vega; Sameh A Youssef; Matthew J Edwards; Daniel Oehlrich; Nina Van Opdenbosch

Affiliations1. Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, USA; 2. Janssen Interventional Oncology, Beerse, Belgium; 3. Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), Toledo, Spain; 4. Janssen Research & Development, LLC, In Vivo Sciences (IVS), Beerse, Belgium; 5. Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), Beerse, Belgium; 6. Janssen Research & Development, LLC, Preclinical Sciences and Translational Safety (PSTS), Spring House, USA; 7. Janssen Research & Development, LLC, Discovery Pharmaceutics, Beerse, Belgium; 8. Janssen Research & Development, LLC, Preclinical Sciences and Translational Safety (PSTS), Beerse, Belgium; 9. Charles River Laboratories, Beerse, Belgium; 10. Janssen Interventional Oncology, Spring House, USA; 11. Janssen Research & Development, LLC, Therapeutic Discovery, Beerse, Belgium; 12. Janssen Research & Development, LLC, Drug Metabolism and Phamacokinetcs (DMPK), Beerse, Belgium

AuthorsXian-Hui Zhu; Ya-Ping Zhou; Qiao Zhang; Ming-Yi Zhu; Xiao-Wei Song; Jun Li; Jiang Chen; Yun Shi; Kang-Jian Sun; Yong-Jie Zhang; Jing Zhang; Tian Xia; Bao-Sheng Huang; Fan Meng; Qi-Gang Zhou

Affiliations1. Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, China; 2. Sir Run Run Hospital, Nanjing Medical University, Nanjing, China; 3. Changzhou Hygiene Vocational Technology College, Changzhou, China; 4. Suqian First Hospital, Nanjing Medical University, Suqian, China; 5. Centre of Medicinal Preparations, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China; 6. Department of Neurosurgery, The Second Affiliated Hospital of Nantong University, Nantong First People’s Hospital, Nantong, China; 7. Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; 8. Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China; 9. Department of Neurosurgery, Nanjing Jinling University, Nanjing, China; 10. Department of Human Anatomy, Human Brain Tissue Resource Center of Nanjing Medical University, National Health and Disease Human Brain Tissue Resource Center-sub-center of Nanjing Medical University, Nanjing, China; 11. The Key Center of Gene Technology Drugs of Jiangsu Province, Nanjing Medical University, Nanjing, China; 12. Department of Pharmacy of First Affiliated Hospital of Nanjing Medical University, Nanjing, China

AuthorsCristina Alarcón-Vila; Laura Hurtado-Navarro; Sandra V Mateo; Alejandro Peñín-Franch; Carlos M Martínez; Cristina Molina-López; María C Baños; Ana I Gómez; Javier Gómez-Román; Alberto Baroja-Mazo; Juan I Arostegui; Natalia Palmou-Fontana; Juan J Martínez-García; Pablo Pelegrin

Affiliations1. Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain; 2. Anatomical Pathology Service, Marqués de Valdecilla University Hospital-IDIVAL, University of Cantabria, Santander, Spain; 3. Department of Immunology, Hospital Clínic, Barcelona, Spain; 4. Biomedical Research Institute August Pi i Sunyer, Barcelona, Spain; 5. School of Medicine, University of Barcelona, Barcelona, Spain; 6. Rheumatology Service, Immunopathology Group, Marqués de Valdecilla University Hospital-IDIVAL, Santander, Spain; 7. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, Murcia, Spain

AuthorsEfil Bayam; Peggy Tilly; Stephan C Collins; José Rivera Alvarez; Meghna Kannan; Lucile Tonneau; Elena Brivio; Bruno Rinaldi; Romain Lecat; Noémie Schwaller; Ludovica Cotellessa; Sateesh Maddirevula; Fabiola Monteiro; Carlos M Guardia; João Paulo Kitajima; Fernando Kok; Mitsuhiro Kato; Ahlam A A Hamed; Mustafa A Salih; Saeed Al Tala; Mais O Hashem; Hiroko Tada; Hirotomo Saitsu; Mariano Stabile; Paolo Giacobini; Sylvie Friant; Zafer Yüksel; Mitsuko Nakashima; Fowzan S Alkuraya; Binnaz Yalcin; Juliette D Godin

Affiliations1. Institut de Génétique et de Biologie Moléculaire et Cellulaire, IGBMC, Illkirch, France; 2. Centre National de la Recherche Scientifique, CNRS, UMR7104, Illkirch, France; 3. Institut National de la Santé et de la Recherche Médicale, INSERM, U1258, Illkirch, France; 4. Université de Strasbourg, Strasbourg, France; 5. Université de Bourgogne, INSERM UMR1231, Dijon, France; 6. Université de Strasbourg, CNRS, GMGM UMR7156, Strasbourg, France; 7. INSERM, U1112, CRBS (Centre de recherche en biomédecine de Strasbourg), Université de Strasbourg, Strasbourg, France; 8. Université de Lille, INSERM, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition UMR-S 1172, Lille, France; 9. Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; 10. College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; 11. Mendelics Análise Genomica SA, CEP 02511-000, Sao Paulo, Brazil; 12. Placental Cell Biology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, USA; 13. Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil; 14. Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan; 15. Department of Pediatric and Child Health, Faculty of Medicine University of Khartoum, Khartoum, Sudan; 16. Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia; 17. Department of Pediatrics, Genetic Unit, Armed Forces Hospital, Khamis Mushayt, Saudi Arabia; 18. Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; 19. Division of Pediatrics, Chibaken Saiseikai Narashino Hospital, Chiba, Japan; 20. Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Japan; 21. Center of Genetics and Prenatal Diagnosis “Zygote”, Salerno, Italy; 22. PCBIS-IMPReSs, Plateforme de Chimie Biologique Intégrative de Strasbourg, UAR 3286 CNRS/Université de Strasbourg, Illkirch, France; 23. Human Genetics, Bioscientia GmbH, Ingelheim, Germany; 24. Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; 25. INSERM UMR1231, Université de Bourgogne, Dijon, France

AuthorsYongzhan Sun; Quan Zou; Huizheng Yu; Xiaoping Yi; Xudan Dou; Yu Yang; Zhiheng Liu; Hong Yang; Junya Jia; Yupeng Chen; Shao-Kai Sun; Lirong Zhang

Affiliations1. The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China; 2. School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China; 3. Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, China; 4. Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China; 5. Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China; 6. Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China; 7. Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, China; 8. School of Medical Imaging, Tianjin Medical University, Tianjin, China

AuthorsLindsey Van Haute; Petra Páleníková; Jia Xin Tang; Pavel A Nash; Mariella T Simon; Angela Pyle; Monika Oláhová; Christopher A Powell; Pedro Rebelo-Guiomar; Alexander Stover; Michael Champion; Charulata Deshpande; Emma L Baple; Karen L Stals; Sian Ellard; Olivia Anselem; Clémence Molac; Giulia Petrilli; Laurence Loeuillet; Sarah Grotto; Tania Attie-Bitach; Jose E Abdenur; Robert W Taylor; Michal Minczuk

Affiliations1. MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK; 2. Broad Institute of MIT and Harvard, Cambridge, USA; 3. Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; 4. Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany; 5. CHOC Children’s Division of Metabolic Disorders, Orange, USA; 6. Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, Newcastle upon Tyne, UK; 7. Department of Biochemistry, University of Cambridge, Cambridge, UK; 8. Department of Children’s Inherited Metabolic Diseases, Evelina London Children’s Hospital, Guy’s & St Thomas’ Hospital NHS Foundation Trust, London, UK; 9. Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK; 10. Department of Clinical Genetics, Guy’s Hospital, Guy’s & St Thomas’ Hospital NHS Foundation Trust, London, UK; 11. Genomics Laboratory, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; 12. Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK; 13. Peninsula Clinical Genetics Service, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; 14. Maternité Port-Royal, Département de Gynécologie-Obstétrique, Hôpital Cochin Broca Hôtel-Dieu, APHP, Paris, France; 15. Service de Médecine Génomique des Maladies Rares, Hôpital Necker-Enfants Malades, APHP, Paris, France; 16. UF de Génétique Clinique, Centre de Référence Anomalies du Développement et Syndromes Malformatifs, Hôpital Trousseau, APHP, Paris, France; 17. INSERM UMR 1163, Imagine Institute, Genetics and Development of the Cerebral Cortex, Université Paris Cité, Paris, France; 18. University of California, Irvine, Department of Pediatrics, Irvine, USA; 19. NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; 20. Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

AuthorsZe-Rong Cai; Wen Wang; Di Chen; Hao-Jie Chen; Yan Hu; Xiao-Jing Luo; Yi-Ting Wang; Yi-Qian Pan; Hai-Yu Mo; Shu-Yu Luo; Kun Liao; Zhao-Lei Zeng; Shan-Shan Li; Xin-Yuan Guan; Xin-Juan Fan; Hai-long Piao; Rui-Hua Xu; Huai-Qiang Ju

Affiliations1. State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China; 2. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China; 3. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, P. R. China; 4. The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China; 5. Department of Clinical Oncology, Shenzhen Key Laboratory for Cancer Metastasis and Personalized Therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, P. R. China