Paper Review Records
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Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration
AuthorsJoshua A. Welsh; Edwin van der Pol; Britta A. Bettin; David R. F. Carter; An Hendrix; Metka Lenassi; Marc‐André Langlois; Alicia Llorente; Arthur S. van de Nes; Rienk Nieuwland; Vera Tang; Lili Wang; Kenneth W. Witwer; Jennifer C. Jones
Affiliations1. Translational Nanobiology Section Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda USA; 2. Vesicle Observation Center, Amsterdam UMC, Location AMC University of Amsterdam Amsterdam The Netherlands; 3. Biomedical Engineering & Physics Amsterdam UMC University of Amsterdam Amsterdam The Netherlands; 4. Laboratory of Experimental Clinical Chemistry Department of Clinical Chemistry, Amsterdam UMC, Location AMC University of Amsterdam Amsterdam The Netherlands; 5. Department of Biological and Medical Sciences, Faculty of Health and Life Sciences Oxford Brookes University Oxford UK; 6. Laboratory of Experimental Cancer Research Department of Human Structure and Repair Ghent University Hospital Ghent Belgium; 7. Cancer Research Institute Ghent Ghent Belgium; 8. Institute of Biochemistry Faculty of Medicine University of Ljubljana Ljubljana Slovenia; 9. University of Ottawa Flow Cytometry and Virometry Core Facility Ottawa Canada; 10. Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine University of Ottawa Ottawa Canada; 11. Ottawa Center for Infection, Immunity and Inflammation Ottawa Canada; 12. Department of Molecular Cell Biology Institute for Cancer Research Oslo University Hospital Norway; 13. VSL Dutch Metrology Institute Delft The Netherlands; 14. National Institute of Standards and Technology (NIST) Gaithersburg MD USA; 15. Departments of Molecular and Comparative Pathobiology and Neurology The Johns Hopkins University School of Medicine Baltimore MD USA
Fusion protein engineered exosomes for targeted degradation of specific RNAs in lysosomes: a proof‐of‐concept study
AuthorsZhelong Li; Xueying Zhou; Xiaotong Gao; Danna Bai; Yan Dong; Wenqi Sun; Lianbi Zhao; Mengying Wei; Xuekang Yang; Guodong Yang; Lijun Yuan
Affiliations1. Department of Ultrasound Diagnostics Tangdu Hospital Fourth Military Medical University Xi'an People's Republic of China; 2. The State Laboratory of Cancer Biology Department of Biochemistry and Molecular Biology Fourth Military Medical University Xi'an People's Republic of China; 3. Department of Hematology Tangdu Hospital Fourth Military Medical University Xi'an People's Republic of China; 4. Department of Physiology Fourth Military Medical University Xi'an People's Republic of China; 5. Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an People's Republic of China
The future of Extracellular Vesicles as Theranostics – an ISEV meeting report
AuthorsCarolina Soekmadji; Bo Li; Yiyao Huang; Haifang Wang; Taixue An; Chunchen Liu; Weilun Pan; Jing Chen; Lesley Cheung; Juan Manuel Falcon‐Perez; Yong Song Gho; Harry B. Holthofer; Minh T. N. Le; Antonio Marcilla; Lorraine O'Driscoll; Faezeh Shekari; Tang Long Shen; Ana Claudia Torrecilhas; Xiaomei Yan; Fuquan Yang; Hang Yin; Yu Xiao; Zezhou Zhao; Xue Zou; Qian Wang; Lei Zheng
Affiliations1. Department of Cell and Molecular Biology QIMR Berghofer Medical Research Institute Brisbane Queensland Australia; 2. Faculty of Medicine The University of Queensland Brisbane Queensland Australia; 3. Department of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou Guangdong China; 4. Department of Molecular and Comparative Pathobiology Johns Hopkins University School of Medicine Baltimore Maryland USA; 5. The Department of Biochemistry and Genetics La Trobe Institute for Molecular Science La Trobe University Bundoora Victoria Australia; 6. Exosomes Laboratory and Metabolomics Platform Center for Cooperative Research in Biosciences (CIC bioGUNE) Basque Research and Technology Alliance (BRTA) Derio Spain; 7. Centro De Investigación Biomédica En Red De Enfermedades Hepáticas Y Digestivas (Ciberehd) Madrid Spain; 8. IKERBASQUE, Basque Foundation for Science Bilbao Spain; 9. Laboratory of Intercellular Communication Department of Life Science POSTECH South Korea; 10. Medical Department University Medical Center Hamburg‐Eppendorf Germany; 11. Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore; 12. Àrea De Parasitologia, Departament De Farmàcia I Tecnologia Farmacèutica I Parasitologia Universitat De València Burjassot Valencia Spain; 13. Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics Health Research Institute La Fe‐Universitat De Valencia Valencia Spain; 14. School of Pharmacy and Pharmaceutical Sciences Panoz Institute & Trinity Biomedical Sciences Institute Trinity College Dublin Dublin Ireland; 15. Trinity St. James's Cancer Institute (TSJCI) Trinity College Dublin Dublin Ireland; 16. Department of Stem Cells and Developmental BiologyCell Science Research Center Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran; 17. Department of Plant Pathology and Microbiology & Center for Biotechnology National Taiwan University Taipei Taiwan; 18. Departamento De Ciências Farmacêuticas UNIFESP Diadema São Paulo Brazil; 19. Department of Chemical Biology the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation the Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian China; 20. Laboratory of Proteomics Institute of Biophysics, Chinese Academy of Sciences Beijing China; 21. University of Chinese Academy of Sciences Beijing China; 22. School of Pharmaceutical Sciences Tsinghua University‐Peking University Joint Center for Life Sciences Tsinghua University Beijing China; 23. Laboratory of Medicine Center Zhujiang Hospital Southern Medical University Guangzhou Guangdong China; 24. Center for Public Health Research Medical School Nanjing University Nanjing China
Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P‐bodies
AuthorsHui Li; Itziar Pinilla‐Macua; Yingshi Ouyang; Elena Sadovsky; Kazuhiro Kajiwara; Alexander Sorkin; Yoel Sadovsky
Affiliations1. Magee‐Womens Research Institute Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh Pittsburgh Pennsylvania USA; 2. Reproductive Department of Xiangya Hospital Central South University Changsha Hunan China; 3. The Third Xiangya Hospital Central South University Changsha Hunan China; 4. Department of Cell Biology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA; 5. Department of Microbiology and Molecular Genetics University of Pittsburgh Pittsburgh Pennsylvania USA
Characterization of brain‐derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake
AuthorsSantra Brenna; Hermann C. Altmeppen; Behnam Mohammadi; Björn Rissiek; Florence Schlink; Peter Ludewig; Christoph Krisp; Hartmut Schlüter; Antonio Virgilio Failla; Carola Schneider; Markus Glatzel; Berta Puig; Tim Magnus
Affiliations1. Neurology Department Experimental Research in Stroke and Inflammation University Medical Center Hamburg‐Eppendorf Hamburg Germany; 2. Institute of Neuropathology University Medical Center Hamburg‐Eppendorf Hamburg Germany; 3. Institute of Clinical Chemistry and Laboratory Medicine Mass Spectrometric Proteomics University Medical Center Hamburg‐Eppendorf Hamburg Germany; 4. UKE Microscopy Imaging Facility University Medical Center Hamburg‐Eppendorf Hamburg Germany; 5. Heinrich Pette Institute Leibniz Institute for Experimental Virology Hamburg Germany
Extracellular vesicles from human iPSC‐derived neural stem cells: miRNA and protein signatures, and anti‐inflammatory and neurogenic properties
AuthorsRaghavendra Upadhya; Leelavathi N. Madhu; Sahithi Attaluri; Daniel Leite Góes Gitaí; Marisa R Pinson; Maheedhar Kodali; Geetha Shetty; Gabriele Zanirati; Smrithi Kumar; Bing Shuai; Susan T Weintraub; Ashok K. Shetty
Affiliations1. Institute for Regenerative Medicine Department of Molecular and Cellular Medicine Texas A&M University College of Medicine College Station Texas USA; 2. Department of Cellular and Molecular Biology Institute of Biological Sciences and Health Federal University of Alagoas Brazil; 3. Department of Biochemistry and Structural Biology UT Health San Antonio San Antonio Texas USA
Plasma extracellular vesicles detected by Single Molecule array technology as a liquid biopsy for colorectal cancer
AuthorsPing Wei; Fei Wu; Bin Kang; Xiaohua Sun; Fabienne Heskia; Alexandre Pachot; Ji Liang; Dawei Li
Affiliations1. Department of Pathology Fudan University Shanghai Cancer Center Shanghai China; 2. Cancer Institute Fudan University Shanghai Cancer Center Shanghai China; 3. Department of Oncology Shanghai Medical College Fudan University Shanghai China; 4. Fudan University Shanghai Cancer Center – InstitutMérieux Laboratory Cancer Institute Fudan University Shanghai Cancer Center Shanghai China; 5. Open Innovation & Partnerships Department bioMerieux (Shanghai) Company Limited Shanghai China; 6. Global Medical Affairs Deptartment bioMérieux SA Marcy l'Etoile France; 7. Open Innovation & Partnerships Department bioMérieux SA Marcy l'Etoile France; 8. Department of Colorectal Surgery Fudan University Shanghai Cancer Center Shanghai China
Experimental artefacts can lead to misattribution of bioactivity from soluble mesenchymal stem cell paracrine factors to extracellular vesicles
AuthorsThomas E. Whittaker; Anika Nagelkerke; Valeria Nele; Ulrike Kauscher; Molly M. Stevens
Affiliations1. Department of Materials Imperial College London London UK; 2. Department of Bioengineering Imperial College London London UK; 3. Institute of Biomedical Engineering Imperial College London London UK
Salivary extracellular vesicles inhibit Zika virus but not SARS‐CoV‐2 infection
AuthorsCarina Conzelmann; Rüdiger Groß; Min Zou; Franziska Krüger; André Görgens; Manuela O Gustafsson; Samir El Andaloussi; Jan Münch; Janis A. Müller
Affiliations1. Institute of Molecular Virology Ulm University Medical Center Ulm Germany; 2. Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment School of Pharmaceutical Sciences Southern Medical University Guangzhou China; 3. Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden; 4. Institute for Transfusion Medicine University Hospital Essen Essen Germany; 5. Core Facility Functional Peptidomics Ulm University Medical Center Ulm Germany
Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging
AuthorsDhanu Gupta; Xiuming Liang; Svetlana Pavlova; Oscar P.B Wiklander; Giulia Corso; Ying Zhao; Osama Saher; Jeremy Bost; Antje M. Zickler; Andras Piffko; Cecile L. Maire; Franz L. Ricklefs; Oskar Gustafsson; Virginia Castilla Llorente; Manuela O. Gustafsson; R. Beklem Bostancioglu; Doste R Mamand; Daniel W. Hagey; André Görgens; Joel Z. Nordin; Samir EL Andaloussi
Affiliations1. Biomolecular Medicine Clinical Research Center Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden; 2. Experimental Cancer Medicine Clinical Research Center Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden; 3. Clinical Research Center Karolinska University Hospital Stockholm Sweden; 4. Department Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy Cairo University Cairo Egypt; 5. Department of Neurosurgery University Medical Center Hamburg‐Eppendorf Hamburg Germany; 6. Evox Therapeutics Limited Oxford UK; 7. Department of Biology, Faculty of Science Cihan University‐Erbil Iraq; 8. Institute for Transfusion Medicine University Hospital Essen University of Duisburg‐Essen Essen Germany; 9. Department of Molecular Therapy National Institute of Neuroscience National Center of Neurology and Psychiatry (NCNP) Tokyo Japan
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