医学
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Ex vivo method for assessing androgen synthesis and histological changes in rat testicular tissue slices treated with azole compounds
作者Kanata Ibi; Akihiro Hirata; Mami Murakami; Hiroki Sakai
作者单位Pharmacokinetics and Safety Department, KAKEN PHARMACEUTICAL CO., LTD., 301 Gensuke, Fujieda-shi, Shizuoka 426-8646, Japan; Pathogenetic Applied Veterinary Science, the Graduate School, Joint Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan
Inert polystyrene nanoplastics-induced liver injury in mice was implicated in intense oxidative stress and inflammation mediated by ferroptosis
作者Ci Ou; Hanpeng Wu; Yichun Chen; Zhengtao Yang; Jingjing Wang; Ershun Zhou
作者单位School of Animal Science and Technology, Foshan University, Foshan, Guangdong 528225, PR China
Phytolacca acinosa Roxb. induces intestinal toxicity through the histamine–MLCK–tight junction axis: Integrated evidence from proteomics, metabolomics, intestinal organoids and epithelial barrier validation
作者Yucheng Qi; Xiaoyu Lin; Yangyi Huang; Kou Zhang; Jie Cao; Xiangyue Kong; Xiaobing Cui; Xingde Zhang; Xinzhi Wang; Hao Wu; Hongli Yu
作者单位Nanjing University of Chinese Medicine, China
Selective AhR modulation by tapinarof reprograms microglial inflammation through the AhR–Nrf2 Axis
作者Rana M. El-Baz; Nahla Waheed; Anwar Abdelnaser
作者单位Department of Biological, Chemical, and Global Health Sciences, School of Sciences and Engineering, The American University in Cairo, P.O. Box 74, New Cairo 11835, Egypt
AMPK/mTOR/ULK1 signaling mediates ncoa4-dependent ferritinophagy in BPA-induced ferroptosis in HT-22 hippocampal neuronal cells
作者Yue Zhang; Yuxin Wang; Ping He; Qiling Liu; Haijun Han; Xuyuan Zhang; Chong Wang
作者单位College of Health Public, Shaanxi University of Chinese Medicine, Xianyang 712046, China; Institute of Brain and Cognitive Science, School of Medicine, Hangzhou City University, Hangzhou 310015, China; Department of Respiratory and Intensive Care, Xian Gaoxin Hospital, Xian, Shaanxi 710000, China; Medical Experiment Center, Shaanxi University of Chinese Medicine, Xianyang 712046, China
Combined lead exposure and high-copper intake exacerbates synaptic loss via METTL3-mediated m6A methylation in mice
作者Ran Li; Shuangshuang Tan; Di Wu; Huijing Wang; Yuqi Li; Jiayi Xiong; Haojie Tian; Tao Wang; Gang Zheng
作者单位The Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, School of Public Health, Fourth Military Medical University, Xi’an 710032, China; Affiliated Renhe Hospital of China Three Gorges University, Yichang 443001, China; Department of Psychosomatic Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China; School of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, China; School of Public Health, Shaanxi University of Chinese Medicine, Xianyang 712046, China
Metabolism and urinary excretion kinetics of 2,4-di-tert-butylphenol after a single oral dose: Characterisation of suitable exposure biomarkers for human biomonitoring
作者Christoph Schmidtkunz; Katharina E. Ebert; Isabell Schönrath; Katja Küpper; Thomas Brüning; Holger M. Koch; Gabriele Leng
作者单位Currenta GmbH & Co. OHG, Institute of Biomonitoring, Chempark, Leverkusen, Germany; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Germany
Hijacked pathways: PFOS, the ATF2/WT1 axis, and the mitochondrial dysfunction in Sertoli cells
作者Jinchen Jiang; Haixia Meng; Hongxia Wang; Shaokai Zheng; Lianlian Jiang; Nannan Zhao; Xiaojun Lin; Jianglan Li; Minjun Qin; Siyu Wu; Lianglin Qiu
作者单位Institute for Applied Research in Public Health, School of Public Health, Nantong University, Nantong 226019, PR China
Utility of monocyte-derived cells to investigate immune-mediated drug-induced liver injury
作者Monique Ulepic; Maria F. Vargas; Stuart Astbury; Magdalena Rausch; Sibylle Pfammatter; Sophia L. Samodelov; Jane I. Grove; Gerd A. Kullak-Ublick; Nicholas R.F. Hannan; Guruprasad P. Aithal; Michele Visentin
作者单位Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK; Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland; TransHeps AG, Weiningen, Zurich, Switzerland; Biodiscovery Institute, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK
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