医学
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ΔA146Ply exerts anti-triple-negative breast cancer effects by inducing ferroptosis via regulation of the CYP24A1-mediated calcitriol-vitamin D receptor pathway
作者Ye Yu; Zhengkun Zhang; Dingxue Wang; Xin Bai; Dan He; Xuxu Ji; Zhaoru Yin; Keyi Xu; Ji Liu; Jiaqiong Zou
作者单位West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Department of Biochemistry & Molecular Biology, West China School of Basic Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China; Department of Basic Medical Sciences, Sichuan College of Traditional Chinese Medicine, Mianyang 621000, Sichuan, China; School of Clinical Medical Sciences, Southwest Medical University, Luzhou 646000, Sichuan, China
Anti-colorectal cancer activity of sertraline in mice involves regulation of arachidonic acid metabolism revealed by UPLC-Q Exactive Orbitrap MS-based metabolomics
作者Yihong Shen; Leping He; Chenglong Zheng; Dongmeng Liu; Zongmao He; Yuxia Zou; Guo-Sheng Wu; Chengwei He; Xiaofeng Wang; Ren-Bo Ding; Jiaolin Bao
作者单位Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China; Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Hainan Medical University, Haikou 571199, China; Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China; The State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macao, 999078, China
Polystyrene nanoplastics exposure induces reproductive toxicity in male mice associated with the gut–liver/testis axis
作者Fahao Hou; Yan Xuan; Tengxiao Liu; Yue Jiang; Yile Bao; Tiantian Wu; Yujie Zhang; Junhua Wu; Mengfei Ren; Binbin Huang; Zhi Wang; Maozhen Han
作者单位School of Life Sciences, Anhui Medical University, Hefei 230032, Anhui, China; School of Biomedical Engineering, Anhui Medical University, Hefei 230032, Anhui, China; Department of Clinical Medicine, The First School of Clinical Medicine, Anhui Medical University, Hefei 230032, Anhui, China; School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China; Key Laboratory for Environment and Disaster Monitoring and Evaluation of Hubei, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430077, China
RAB17 downregulation elicits antitumor impacts in prostate cancer by triggering ferroptotic cell death through the regulation of TfR1-mediated iron overload
作者Dongli Ruan; Wanghui Su; Yang Zhang; Xiulong Ma
作者单位Department of Urology and Transplantation Surgery, Shaanxi Provincial People's Hospital, Xi'an 712038, Shaanxi, China; Department of Radiotherapy, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an 710004, Shaanxi, China
Irisin restores testicular metabolic homeostasis and spermatogenesis against chronic unpredictable stress in rats: An integrated 1H NMR metabolomics and molecular study
作者Itishree Dubey; Gurvinder Singh; Dinesh Kumar; Sapana Kushwaha
作者单位Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli (NIPER-R), Lucknow, Uttar Pradesh 226002, India; Centre of Biomedical Research (CBMR), SGPGIMS Campus, Lucknow, Uttar Pradesh 226014, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
Salvigenin alleviates diabetic nephropathy through Nrf2-mediated modulation of renal inflammation and ferroptosis
作者Xiaoxu Ge; Juan Du; Jiajia Wang; Liuqing Xi; Wenfang Peng; Shan Huang; Ying Xie
作者单位Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China; Department of Endocrinology, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200336, China; Hongqiao International Institute of Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai 200336, China
Neuroprotective effect of miR-519a-3p downregulation against sevoflurane-induced cognitive dysfunction via regulating ESR1
作者Weiwei Lin; Dan Yu; Xiating Shi; Wanchao Liu
作者单位Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital (Affiliated to Fuzhou University), Fuzhou 350000, China; Department of Anesthesiology, Jilin Provincial Corps Hospital of Chinese People's Armed Police Force, Changchun 130052, China; Department of Anesthesiology and Surgery, The Second Hospital, Lanzhou University, Lanzhou 730030, China
Inhibition of Calpain-1 ameliorates doxorubicin-induced cardiotoxicity by suppression of p53-mediated ferroptosis
作者Zhuo Zhang; Xinbin Zheng; Dabao Xiao; Mengya Zeng; Junru He; Shaowu Xiao; Maozhong Yao; Yuewu Chen
作者单位Department of Cardiovascular Internal Medicine, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, PR China; Hainan Medical University, Haikou, Hainan 571199, PR China; Cardiovascular Systemic Disease Clinical Medical Center of Hainan Province, Haikou, Hainan 570311, PR China; Clinical Research Center, Hainan Hospital, Guangdong Provincial Hospital of Chinese Medicine, Hainan Medical University, Haikou, Hainan 570000, PR China; Hainan Clinical Research Center for Preventive Treatment of Diseases, Haikou, Hainan 570000, PR China
Identification of candidate microRNA biomarkers of mouse cholangiocyte injury by global miRNAome analysis
作者Lawrence Howell; Joseph P. Brown; Shiva Seyed Forootan; Ben Francis; Carolyn Jones; Lucia Livoti; Lorenzo Ressel; Emanuele Ricci; Martin Bushell; Chris Goldring
作者单位University of Liverpool, Department of Pharmacology and Therapeutics, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, UK; University of Liverpool, Department of Biostatistics, Waterhouse Building, 1-5 Brownlow Street, Liverpool L69 3GL, UK; University of Leicester, Leicester Drug Discovery and Diagnostics (LD3), Hodgkin Building, 412 Lancaster Road, Leicester LE1 7HB, UK; University of Liverpool, Institute of Infection, Veterinary and Ecological Sciences, Leahurst Campus, Neston, Wirral CH64 7TE, UK; University of Glasgow, School of Cancer Sciences, Garscube Estate, Switchback Road, Bearsden G61 1QH, UK; CRUK Beatson Institute, Garscube Estate, Switchback Road, Bearsden G61 1BD, UK; Alteryx, Laguna Canyon Road, Irvine, CA 92618, USA
Untargeted serum lipidomics reveals lipid metabolic disturbances and identifies candidate lipid biomarkers in acute diquat poisoning
作者Xinxin Huang; Xunan Kan; Lei Xiao; Chuanguang Han; Ge Li; Quan Xia; Qianli Zou; Qinhai Ma; Shuai Song
作者单位Department of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, Hefei 230022, China; Department of Pharmacy, Dongcheng Branch of the First Affiliated Hospital of Anhui Medical University (Feidong People's Hospital), Hefei 231600, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510230, China
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