医学
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T-2 toxin disrupts Alzheimer's-relevant App/Tau homeostasis via circadian-p53-senescence crosstalk: Evidence from human neuroblastoma cells
作者Tong Nie; Junyao Li; Shiqing Tan; Shixiang Chen; Denian Yang; Eugenie Nepovimova; Qinghua Wu; Kamil Kuca
作者单位College of Life Science, Yangtze University, Jingzhou 434025, China; Department of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové 500 03, Czech Republic; Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove 500 03, Czech Republic; Faculty of materials science and technologies, VSB-Technical University of Ostrava, Ostrava-Poruba 70800, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove 50005, Czech Republic
Cinnamaldehyde protects against aluminum oxide nanoparticle–induced cognitive dysfunction in male Swiss mice by attenuating hippocampal ERK/p38 hyperphosphorylation and enhancing
作者Mojdeh Ahmadi; Nahid Mehrbeheshti; Roksana Soukhaklari; Maryam Moosavi
作者单位Shiraz Neuroscience Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Cardiology, Medical University of Graz, Graz, Austria
Keap1/Nrf2 mediated ferroptosis in early-life lead exposure-induced cognitive dysfunction in mice
作者Feiyu Zhao; Liming Huang; Binbin Yang; Ruokun Wei; Fan Qiao; Zihao Qi; Huishuai Li; Zhenning Li; Yuanyuan Fang; Dongjie Peng; Shaojun Li
作者单位Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, China; Department of Maternal & Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning, China; The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory Base of Precision Medicine in Cardiocerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, Nanning, China
Combined thermal stress and nanoplastic exposure induce oxidative-mediated neurodevelopmental toxicity and behavioral alterations in zebrafish
作者Emriye Yildiz; Ekrem Sulukan; Onur Şenol; Mehmet Atakay; Alper Baran; Meryem Kankaynar; Metin Kiliçlioğlu; Serkan Yildirim; Bekir Sali̇h; Saltuk Buğrahan Ceyhun
作者单位Aquatic Biotechnology Laboratory, Fisheries Faculty, Atatürk University, Erzurum 25240, Türkiye; Department of Aquaculture Engineering, Graduate School of Natural and Applied Science, Atatürk University, Erzurum 25240, Turkey; Basic Science Department, Faculty of Fisheries, Atatürk University, Erzurum 25240, Türkiye; Department of Analytical Chemistry, Faculty of Pharmacy, Atatürk University, Erzurum 25240, Türkiye; Department of Chemistry, Faculty of Science, Hacettepe University, Ankara 06800, Türkiye; Department of Food Quality Control and Analysis, Faculty of Veterinary, Atatürk University, Erzurum 25240, Türkiye; Department of Nanoscience, Graduate School of Natural and Applied Science, Atatürk University, Erzurum 25240, Türkiye; Department of Pathology, Faculty of Veterinary, Atatürk University, Erzurum, Türkiye; Department of Pathology, Faculty of Veterinary Medicine, Kyrgyz-Turkish Manas University, Chingiz Aitmatov Campus, Bishkek, Bishkek 720038, Kyrgyzstan; Aquaculture Department, Fisheries Faculty, Atatürk University, Erzurum 25240, Türkiye
Chronic cocaine exposure disrupts cholinergic neuron integrity and function in organotypic slices of the laterodorsal tegmentum
作者Cesar R. Romero-Leguizamón; Mohamed R. Elnagar; Kristi A. Kohlmeier
作者单位Department of Drug Design and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
Firemaster 550 differentially alters gene expression underlying synaptic function in amygdala of prairie voles after gestational or lactational exposure
作者Andrew J. Newell; Abdull J. Massri; Sagi E. Gillera; Jenna M. Berger; Vijayalakshmi Panduri; Liwen Liu; Kevin Gerrish; Heather B. Patisaul
作者单位Mechanistic Toxicology Branch, Division of Translation Toxicology, National Institute of Environmental Health Sciences, USA; NIEHS Integrative Bioinformatics Support Group, Division of Intramural Research, USA; NIEHS Genomics Core, Division of Intramural Research, Epigenetics and RNA Biology Laboratory, USA
Sublethal bisphenol A compromises BV-2 microglial immunity by disrupting TLR4 signaling through the ROS/Nrf2-Keap1/HO-1 axis
作者Ching-Tien Lee; Cheng-Fang Hsieh; Jiz-Yuh Wang
作者单位School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei 112303, Taiwan; Division of Geriatrics and Gerontology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
Honokiol alleviates oxidative stress, neuroinflammation, and apoptosis in excitotoxicity induced by ouabain, a Na + /K + -ATPase inhibitor
作者Mehmet Demir; Feyza Basak; Tansu Kusat; Sarab Hayder Weli Weli
作者单位Karabuk University, Faculty of Medicine, Department of Physiology, Karabuk, Turkey; Karabuk University, Faculty of Medicine, Department of Histology and Embryology, Karabuk, Turkey; Karabuk University, Faculty of Medicine, Department of Medical Biochemistry, Karabuk, Turkey
Ginsenoside Rh3 induces barrier-associated injury in an in vitro blood-brain barrier model with involvement of MMP2/9
作者Yuheng Wang; Cong Hu; Yu Liu; Xiaojing Wang; Geng Chang; Jianwen Chen
作者单位Department of Neurology, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi 563000, China
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