医学
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Prior Toll-like receptor 3 stimulation abolishes the ability of a MAPK/ERK kinase inhibitor to increase lipopolysaccharide-induced nitric oxide production concomitant with tumor necrosis factor-α suppression
作者Ryota Hashimoto; Yaojia Wu; Kaily Fujimoto; Haruto Shintani; Hiroshi Koide; Youichi Katoh
作者单位Laboratory of Cell Biology, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Bunkyo-ku, Japan; Department of Physiology, Juntendo University Faculty of Medicine, Bunkyo-ku, Japan; Juntendo University Graduate School of International Liberal Arts, Bunkyo-ku, Japan; Laboratory of Molecular and Biochemical Research, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Bunkyo-ku, Japan; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Japan
Impact of Δ9-tetrahydrocannabinol and oxycodone coadministration on measures of antinociception, dependence, circadian activity, and reward in mice
作者Richard A. Slivicki; Justin G. Wang; Kayla V. Kucz; Jakayla Folarin Hines; Vy Trinh Tran Nhat; Alexxai V. Kravitz; Meaghan C. Creed; Robert W. Gereau
作者单位Department of Anesthesiology, Washington University Pain Center, St. Louis, Missouri; Division of Biology and Biomedical Sciences, Neuroscience Graduate Program, St. Louis, Missouri; Department of Psychiatry, Washington University, St. Louis, Missouri; Department of Neuroscience, Washington University, St. Louis, Missouri; Department of Biomedical Engineering, Washington University, St. Louis, Missouri
Aryl hydrocarbon receptor as a molecular mediator in the induction of human aldehyde oxidase gene expression
作者Szu Ling Yeap; Cassandra Ching Lin Yap; Shi Han Tay; Linghua Harris Zhang; Aik Jiang Lau
作者单位Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore; Axela Biosciences, Inc, Whippany, New Jersey; College of Pharmacy, Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
M1 muscarinic receptor modulation drives sex-specific alterations of Alzheimer’s pathophysiology in APPswe/PSEN1ΔE9 mice
作者Wesam Bassiouni; Emily Ye; Tash-Lynn L. Colson; Stephen S.G. Ferguson; Khaled S. Abd-Elrahman
作者单位Department of Anesthesiology, Pharmacology and Therapeutics, and Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; Department of Cellular and Molecular Medicine, Ottawa Brain and Mind Research Institute, University of Ottawa, Ottawa, Ontario, Canada; Department of Medical Sciences, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates
Blocking interleukin 33 reduces joint, systemic, and lung inflammatory responses in the combined collagen-induced arthritis-inhalant endotoxin exposure model
作者Jill A. Poole; Jacob L. Larsen; Geoffrey M. Thiele; Todd A. Wyatt; Amy J. Nelson; Michael J. Duryee; Angela M. Gleason; Oliver W. Schanze; Aaron D. Schwab; John D. Dickinson; Deanna Mosley; Michael Lush; Han-Jun Wang; E. Suzanne Cohen; Bryant R. England; Ted R. Mikuls
作者单位Division of Allergy and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, Nebraska; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska; Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska; Bioscience Asthma, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
Loaded and coated: Outer membrane vesicles get a critical boost from a lipopolysaccharide adjuvant payload in a rationally designed anti-Helicobacter pylori nanoparticle
作者Jesse A. Jones; Dmitri Simberg
作者单位Department of Biomedical and Pharmaceutical Sciences, L.S. Skaggs College of Pharmacy, Kasiska Division of Health Sciences, Idaho State University, Pocatello, Idaho; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences and Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Translational Bio-Nanosciences Laboratory, Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, Colorado
Striatal remodeling in Parkinson disease
作者Soren D. Emerson; Chiho Sugimoto; Sarah C. Honeycutt; Erin S. Calipari
作者单位Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, Tennessee; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee; Department of Psychiatry and Behavioral Sciences, Vanderbilt University, Nashville, Tennessee
α-Synuclein regulates monoamine transporter capacity and amphetamine-induced efflux via modulation of transporter expression
作者Iina Ludwig; Samuel Moser; Marina Lukenic; Michael Connor; Amila Sofic; Samantha Kaltenbrunner; Constantin Pätzold; Alexander Hausleitner; Catherine Gilbert; Sonja Sucic; Marko Roblek; Thomas Steinkellner
作者单位Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
Preclinical pharmacology of N-pyrrolidino “nitazene” opioids appearing in nonmedical drug markets
作者Grant C. Glatfelter; Alexander D. Maitland; Nicholas R. Gonzalez; Donna Walther; Li Chen; Lei Shi; Michael H. Baumann
作者单位Designer Drug Research Unit, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland; Computational Chemistry and Molecular Biophysics Section, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland
Bronchorelaxant and anti-inflammatory profile of ensifentrine alone and combined with inhaled medications in lipopolysaccharide-challenged human airways from chronic obstructive pulmonary disease donors
作者Luigino Calzetta; Tara Rheault; Shima Gholamalishahi; Francesco Facciolo; Giuseppe Cardillo; Paola Rogliani
作者单位Unit of Respiratory Clinical Pharmacology, Department of Clinical Science and Translational Medicine, University of Rome “Tor Vergata”, Rome, Italy; Verona Pharma plc, Raleigh, North Carolina; Unit of Respiratory Medicine, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy; Thoracic Surgery Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy; Department of Thoracic Surgery, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy
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