医学
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Possible origin and suppression of apparent +56 Da impurities during peptide synthesis
作者Wenqiang Liu; Huanjie Zhu; Yani Wang; Zerun Song; Chunyu Jin; Jiongkun Peng; Chong Guo; Zhongping Tan
作者单位State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Isolation, structural elucidation and cytotoxicity evaluation of novel degradation impurities of futibatinib
作者Liangliang Cai; Ming Sun; Xiaofei Ma; Wenyi Wu; Qin Wang; Xinfeng Wang
作者单位Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China; Department of Medical Ultrasound, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China; Department of Quality Inspection, Sinopharm Holdings Nantong Co., Ltd, Nantong, Jiangsu 226001, China; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Department of Hematology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China
Forced degradation studies reveal favorable stability of bispecific antibodies generated using the B-Body® platform
作者Xin Chen; Joseph Gawdzik; Hongbo Chen; John Painter; Jeremiah Woodall; Brian Anderson; Jessica Wiwczar; Nicholas Marshall
作者单位Protein Science, Invenra, Madison, WI, USA
Validated LC–MS/MS method for ultra-trace determination of N-nitroso-desmethyl sumatriptan in sumatriptan succinate injection
作者Srivathsa Degekar G.; Niranjan Patra
作者单位Department of Chemistry, Koneru Lakshmaiah Education Foundation, Greenfield, Vaddeswaram, Guntur, Andhra Pradesh 522502, India; Department of Analytical formulation-Injectables, Eugia Pharma Research Centre, Sangareddy, Telangana 502329, India
Isolation and identification of two novel oxyphenisatin analogues found as adulterants in health food products
作者Jian Sun; Hong Yu; Chee Leong Kee; Jingxian Zhang; Yingying Ran; Fan Huang; Heng Zhou; Xiuhong Mao; Xiaowei Ge; Qing Hu
作者单位NMPA Center for Innovation and Research in Regulatory Science, Shanghai Institute for Drug Control, Shanghai 201203, China; Pharmaceutical Laboratory, Applied Sciences Group, Health Sciences Authority, 11 Outram Road, 169078, Singapore
Detection and structural elucidation of preservative-excipient isomeric esters of benzyl alcohol and citric acid in a topical hydrogel formulation on accelerated stability by LC-MS and benchtop NMR spectroscopy
作者Adam Socia; Meredith M. Dinges; Jahangir Alam; Xueguang Fang; Michael Wey
作者单位Organon & Co., 727 Norristown Road, Building 4, Suite 100, Lower Gwynedd, PA 19002, USA
LC-MS/MS quantification of endogenous taurine in plasma and urine using surrogate matrix calibration and background subtraction: Application to renal transporter phenotyping
作者Kathley Lanna Rezende de Azevedo; Álef Machado Gomes Pego; Adriana Rocha; Jhohann Richard de Lima Benzi; Patrícia Pereira dos Santos Melli; Ricardo Carvalho Cavalli; Geraldo Duarte; Vera Lucia Lanchote; João Paulo Bianchi Ximenez
作者单位Department of Clinical Analysis, Food Science and Toxicology, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Department of Obstetrics and Gynecology, Ribeirão Preto Medical Schoo, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Chemotype matters: NMR-guided profiling of Cinnamomum tamala essential oil and impact on antibacterial activity
作者Ankur Kumar Tanwar; Vishu Pal; Amritaparna Maity; Debanjan Chatterjee; Akanksha Joshi; Nobuyuki Mase; Tarun Kumar Sharma; Inder Pal Singh
作者单位Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab 160062, India; Department of Medical Devices, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab 160062, India; Research Institute of Green Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka 432-8561, Japan
Development and evaluation of a Raman detector for non-destructive identification and quantitation of cytostatic drugs in different primary packaging containers
作者Philipp Siegmund; Stefan Klinken-Uth; Andrea Michel; Michael C. Hacker; Jörg Breitkreutz; Björn Fischer
作者单位Institute of Pharmaceutics and Biopharmaceutics, Faculty of Mathematics and Natural Sciences, Heinrich Heine University, Universitätsstraße 1, Düsseldorf 40225, Germany
Identification and quantitation strategies of circulating cysteine-conjugated linker-payload catabolites and free payload from a cleavable-linker ADC
作者Hermes Licea-Perez; Kasie Fang; Kevin Colizza
作者单位Bioanalysis and Soluble Biomarkers, GSK 1250 S. Collegeville Rd, PA 19426, USA; DMPK - US Biotransformation, GSK 1250 S. Collegeville Rd, Collegeville, PA 19426, USA
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