医学
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Identifying a suitable human hepatic in vitro model to study aryl hydrocarbon receptor-mediated CYP1A1 and CYP1A2 expression
作者Ann-Kathrin Lenich; Lisa-Marie Reindl; Stephanie Ruez
作者单位Department of Global Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany
Paternal glufosinate exposure alters early embryonic inflammatory signals and offspring neurobehavior in IVF-derived mice
作者Zhilu Pei; Dayu Hu; Tong Zhang; Jie Sun; Weiyue Hu
作者单位Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, China; Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China
Nanoplastics induce β-cells dysfunction via the p-AKT/c-FOS/c-JUN signaling axis
作者Xin-Yang Wang; Hong-Zhan Liu; Sheng-Yuan Wang; Xiao-Feng Zhang
作者单位Department of Toxicology, Public Health School, Harbin Medical University, China. No 157, Baojian Road, Nangang District, Harbin City, Heilongjiang Province, 150081, China; Department of Occupational Health, Public Health School, Harbin Medical University, China. No 157, Baojian Road, Nangang District, Harbin City, Heilongjiang Province, 150081, China
Lianhua Qingwen granules biphasically regulate CYP3A4 and mediate metabolic drug interactions via LXRα-interfered dynamic rearrangement of PXR–HSP90α/RXRα/SRC-1 complex
作者Kexin Yang; Jiangping Li; Xinqian Zhao; Zuqiang Wu; Linhu Ye
作者单位School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, 561113, China; Department of Pharmacy, School of Medicine, The Sixth Affiliated Hospital of South China University of Technology (Nanhai District People's Hospital of Foshan), Foshan, 528200, China; Zhejiang Provincial People's Hospital Bijie Hospital & the First People's Hospital of Bijie, Bijie, 551700, China
Polystyrene nanoparticles impair endometrial decidualization in early pregnant mice via oxidative stress-driven autophagy suppression and ferroptosis induction
作者Li-Qing Wang; Qian-Feng Qiao; Huang-Nian You; Yi-bin Zheng; Xiao-Mei Wu; Wen-Jie Yu; Zeng Liu; Wen-Juan Song; Lin-Hong Zhang; Jia-Rui Hu; Xin-Yu Mao; Yong-Jiang Zhou
作者单位School of Public Health, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, Hainan Province, China; Obstetrical Department, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China; School of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan Province, China
Di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate upregulate PPARG and induce metabolic reprogramming in hepatocellular carcinoma cells: a pan-cancer and metabolomics study
作者Yuxing Liao; Huiqing Liang; Hongmei Huang; Wenjie Yang; Shuangyan Su; Cuixiang Zhang; Yuxi Xiao; Jiaqi Gong; Qirong Yang; Guihua Wang; Guiyuan Chen; Xueying Li
作者单位Department of Biochemistry and Molecular Biology, School of Basic Medicine, Dali University, Dali City, Yunnan province, PR China; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Dali University, Dali City, Yunnan province, PR China
Probabilistic quantitative risk assessment of unintended egg, milk and wheat allergen exposure under Japan's threshold-based food labelling system
作者Tatsuki Fukuie; Hiroshi Akiyama; Yoshinari Suzuki; Reiko Adachi; Shouhei Takeuchi; Masaya M. Saito; Yukihiro Ohya; Hirohisa Saito
作者单位Allergy Center, National Center for Child Health and Development, Tokyo, Japan; Division of Foods, National Institute of Health Sciences, Kanagawa, Japan; Department of Analytical Chemistry, Hoshi University, Tokyo, Japan; Division of Biochemistry, National Institute of Health Sciences, Kanagawa, Japan; Department of Nutrition Science, Faculty of Nursing and Nutrition, University of Nagasaki, Nagasaki, Japan; Department of Information Security, Faculty of Information Systems, University of Nagasaki, Nagasaki, Japan; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
Methylparaben promotes colorectal tumor growth through nuclear receptor–mediated transcriptional reprogramming and inflammatory signaling: Evidence from integrated transcriptomics and network toxicology
作者Zhisheng Ma; Zheng Zhang; Yao Zhou; Zhaoyu Song; Xinyue Wang; Peifeng Chen; Wannian Sui; Jiajun Qian; Along Li; Maoming Xiong; Guodong Cao; Wenxiu Han
作者单位Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Methylparaben and ethylparaben exposure through breast milk in the first six months of lactation: A Taiwanese cohort study with estimated daily intake for breastfed infants
作者Ting Chang; Ching-Chung Tsai; Ting-I Lin; Hsien-Kuan Liu; Jau-Ling Suen; San-Nan Yang; Chien-Yi Wu; Pei-Ling Wu; Yung-Ning Yang
作者单位Department of Pediatrics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; School of Medicine, I-Shou University, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Genotoxicity, subchronic toxicity, and allergenicity evaluation of IgG Binding Protein CBB produced from Komagataella phaffii
作者Dayna Lozon; Kevin Scaife; Barry Lynch; Keal Gracey; Alica Šoltésová; Sandra Wingaard Thrane; Louise Kristine Vigsnæs; Signe Christensen; Rune Thorbjørn Nordvang; Nigel Baldwin; Christel Jørgensen
作者单位Intertek Health Sciences Inc., 2233 Argentia Road, Suite 201, Mississauga, Ontario, L5N 2X7, Canada; Labcorp Early Development Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK; Labcorp Early Development Laboratories Ltd., Woolley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, UK; Bactolife A/S, Rønnegade 8, Copenhagen, 2100, Denmark; Baldwin Advisory Services Ltd., Brickfield Cottage, Christchurch, UK
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