生物学
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Directed biosynthesis of the designer peptidyl nucleoside antibiotics featuring a simplified azetidine-containing moiety
作者Rong Gong; Tianzhu Li; Liwei Zhou; Yuanyuan Liu; Tong Zhang; Yini Qin; Xinyue Zeng; Boyu Jin; Jiahong Wang; Zixin Deng; Xuemin Song; Wenqing Chen
作者单位Department of Anesthesiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China; International Innovation Center for Forest Chemicals and Material, Nanjing Forestry University, Nanjing, 210037, China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan, 430071, China
Ribosome engineering enhances genetic code expansion in Saccharomyces cerevisiae
作者Xiaoxu Chen; Wenlu Shen; Xianqing Chen; Fangfang Zhang; Bo Yang; Zhiyong Yue; Guanghou Zhao
作者单位Key Laboratory of Natural Anti-aging Product Mining and Biosynthesis of Shaanxi Higher Education Institutes, College of Medicine, Xi’an International University, Xi’an, 710077, China; School of Life Science and Technology, Northwestern Polytechnical University, Xi’an, Shaanxi, 710129, China; Biocytogen (Beijing) Co., Ltd., Beijing, 102609, China
Characterization of two key cytochrome P450 enzymes in Isodon amethystoides and de novo production of 3α,15β-dihydroxy-ent-kaurene in yeast
作者Yanying Chen; Xinqi Song; Yanan Wang; Yang Han; Meng Xia; Shijun Yuan; Ying Ma; Jian Wang; Qing Ma; Shuang Liu; Ping Su; Luqi Huang
作者单位School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Development of a new recombineering system for Edwardsiella species
作者Yunjia Deng; Jiayue Sun; Haiyi Ji; Mingjia Qu; Jiayi Zhu; Xin Meng; Yuntao Ma; Jinqi Liu; Shouying Xu; Zhendong Liu; Youming Zhang; Jun Fu; Aiying Li; Ruijuan Li
作者单位State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, 266237, China; College of Food Science, Tibet Agriculture and Animal Husbandry University, Key Laboratory of Deep Processing and High-Value Utilization of Specialty Agricultural and Livestock Products in the Xizang Autonomous Region, Nyingchi, 860000, China
Strategy for enhanced production of A40926B0 in Nonomuraea gerenzanensis using an efficient CRISPR/AsCas12f1 system
作者Xiaoru Wang; Hongmei Zhai; Dandan Gu; Yongchao Wang; Jiali Gao; Luxi Du; Liuxu Zhuo; Xiaobing Li; Yu Wang
作者单位College of Chemical Engineering, Shijiazhuang University, Shijiazhuang, Hebei Province, 050035, China; Hebei Provincial University Microbiology Pharmaceutical Application Technology Research and Development Center, Shijiazhuang, 050035, China; Hebei Key Laboratory of Pharmaceutical Polymer Excipients, Shijiazhuang, 050035, China; Hebei International Joint Research Center for Biopharmaceutical, Shijiazhuang University, Shijiazhuang, Hebei Province, 050035, China
Combinatorial metabolic engineering of Mycobacterium neoaurum LY-2 for efficient androstenedione production from phytosterols
作者Liyang Xu; Chuxian Peng; Wenjing Pan; Yingjia Tong; Jinsong Shi; Zhenghong Xu; Hui Li
作者单位School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, China; College of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China
Genome-integrated engineering of Escherichia coli Nissle 1917 enables sustained gut-local biosynthesis of 5-hydroxytryptophan
作者Jing Wu; Yifan Yang; Taiyu Li; Baohui Zhang; Zongchao Chen; Jiawei Li; Yi Xiao
作者单位State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, PR China
Systems-level analysis of 1,6-hexanediol stress response and tolerance engineering in Escherichia coli
作者Xinyi Zhang; Lisha Qin; Hongxu Li; Xin Wang; Kequan Chen
作者单位State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China
Gentamicin and d-serine selective pressure to improve the homogeneity of cells expressing target proteins
作者Lucas Gelain; Jing Wui Yeoh; Benjamin Shang Yong Au-Yeung; Stéphane Guillouet; Chueh Loo Poh; Nathalie Gorret; Jee Loon Foo
作者单位CNRS@CREATE, 1 Create Way, Create Tower, 138602, Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, 117456, Singapore; Department of Biomedical Engineering, National University of Singapore, 117583, Singapore; TBI, Université de Toulouse, CNRS, INRAE, INSA, Toulouse, France; Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; National Centre for Engineering Biology (NCEB), Singapore
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