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10 篇有效样本 · 按发表日期由新到旧排列
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USP15 regulates mitotic fidelity, metastatic potential, and chemotherapeutic response in ovarian cancer cells
作者Ayokunnumi Ogunsanya; Fatimah Alfaran; Omuya Noel Amadu; Achuth Padmanabhan
作者单位Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, USA; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA
Ultrasound controllable and antigen-independent killing via cis-activating CAR T cells
作者Linshan Zhu; Jiaxin Cui; Chi-Wei Man; Anthony Mouchawar; Xi Yu; Yixuan Huang; Yiqian Wu; Tianze Guo; Hongquan Xu; Longwei Liu; Yingxiao Wang
作者单位Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA; National Biomedical Imaging Center, College of Future Technology, Peking University, Beijing 100871, China; Department of Statistics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Ophthalmology, Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, CA 90033, USA; Department of Bioengineering and Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Simultaneous targeting of IL-10 and PD-(L)1 pathways with a bispecific anti-PD-L1/IL-10-trap antibody enhances T cell responses
作者Latika Singh; Natalia Zabavnik; Sambasivan Venkatasubramanian; Sagi Barzilai; Jing Ni; Andreas Evers; Olga Bogatyrova; Melissa G. Derner; Stefan Zielonka; Rinat Zaynagetdinov; Laura Helming
作者单位Research Unit Oncology, EMD Serono Research and Development Institute, Inc., Billerica, MA 01821, USA; Antibody Discovery and Protein Engineering, Inter-Lab Ltd., Yavne 8122004, Israel; Research Unit Oncology, the Healthcare Business of Merck KGaA, 64293 Darmstadt, Germany; Antibody Discovery and Protein Engineering, the Healthcare Business of Merck KGaA, 64293 Darmstadt, Germany; Research Unit Oncology Data Science, the Healthcare Business of Merck KGaA, 64293 Darmstadt, Germany
Synergistic cell-cycle repression by HDAC/EZH2 co-targeting in H3K27-altered diffuse midline glioma
作者Zili Zhen; Qiang Gao; Yong Ai; Zhihong Qian; Yukui Shang; Yafang Deng; Shuai Chen; Xin Ni; Wei Zhang
作者单位IDG/McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University, Beijing 100084, China; Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750003, China; School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 100084, China; Department of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China; The State Key Laboratory for Complex, Severe, and Rare Diseases, School of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijing 100084, China; Department of Internal Medicine, Peking Union Medical College Hospital, Beijing 100730, China; Neurological Center, Beijing Children’s Hospital Shunyi Women’s and Children’s Hospital, Beijing 101300, China; National Center for Pediatric Cancer Surveillance, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China; Clinical Research Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
Neuroepithelial reprogramming and ERBB vulnerability in canine acanthomatous ameloblastoma
作者Andreas Stephanou; Bo Shui; Deanna Mische; Michael Byron; William P. Katt; Marina Chan; Jennifer K. Grenier; Iwijn De Vlaminck; Gerald E. Duhamel; Taranjit S. Gujral; Praveen Sethupathy; Santiago Peralta
作者单位Department of Biomedical and Translational Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Department of Clinical Sciences, Clinical Programs Center, College of Veterinary Medicine, Cornell University, Box 31, Ithaca, NY 14853, USA; Biotechnology Resource Center, Cornell University, Ithaca, NY 14853, USA
TAP1 deficiency reshapes tumor antigenicity and enables CD8 T cell targeting in colorectal cancer
作者Audrey Merienne; Kathleen Ducoin; Cécile Deleine; Mathilde Deiber; Margot Machu; Edouard Leveque; Romain Oger; Emilie Duchalais; Pierre Fourquier; Céline Bossard; Nathalie Labarrière; Houssem Benlalam; Anne Jarry; Nadine Gervois-Segain
作者单位Nantes Université, University Angers, CHU Nantes, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302/EMR6001, 44000 Nantes, France; LabEx IGO and ImmuNE, Nantes Université, Nantes, France; IRCM, University Montpellier, Inserm, ICM, CNRS, Montpellier, France; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France; Nantes Université, University Angers, INSERM, CNRS, Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers, CRCI2NA, UMR 1307/EMR6001, 44000 Nantes, France; Department of Digestive Surgery and IMAD, CHU Nantes, France; Department of Digestive Surgery, Hôpital Privé Du Confluent, Nantes, France; Department of Pathology, CHU Nantes, IHP Group, Nantes, France
Oncolytic adenovirus incorporating TetO sites in the E1A promoter for controlled replication in TetR-expressing mesenchymal stem cells
作者Ramon Alemany; Silvia Torres-Manjon; Laia Traveset; Rafael Moreno
作者单位Cancer Immunotherapy Group, Oncobell and IProCURE programs, IDIBELL-Institut Català D'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain; Innovation unit, Business Development and Innovation area, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
Reversible control of CAR T cells through PROTAC compound targeting bromodomain mutant
作者Yeongrin Kim; Da Yeon Lee; Ji U. Choi; Moonjung Jeun; Heung Kyoung Lee; Sang Un Choi; Chi Hoon Park
作者单位Data Convergence Drug Research Center, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea; College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea; Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon 34113, Republic of Korea
Feasibility and outcomes of decentralized point-of-care CD19 CAR T cell for relapsed large B cell lymphoma in resource-limited settings
作者Koramit Suppipat; Supannikar Tawinwung; Ornnicha Sathitakorn; Chantiya Chanswangphuwana; Kanhatai Chiengthong; Mutita Surakijboworn; Thiti Asawapanumas; Phandee Watanaboonyongcharoen; Palada Pitakkitnukun; Manaschanok Tippawan; Supanat Kumjan; Udomsak Bunworasate; Nattiya Hirankarn; Kitsada Wudhikarn
作者单位Center of Excellence in Cellular Immunotherapy, Chulalongkorn University, Bangkok 10330, Thailand; Department of Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Division of Hematology and Center of Excellence in Translational Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Center of Excellence in Pediatric Hematology/Oncology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Transfusion Medicine Unit, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand; Transplant and Cellular Therapy Unit, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand; Center of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
Augmenting CAR T cell functionality and metabolism through CD39 downtuning
作者Dennis Christoph Harrer; Jeremy Baldwin; Markus Barden; Hong Pan; Bence Gergely; Árpád Szöőr; György Vereb; Wolfgang Herr; Hinrich Abken
作者单位Department of Hematology and Internal Oncology, University Hospital Regensburg, 93053 Regensburg, Germany; Leibniz Institute for Immunotherapy, Div. Genetic Immunotherapy, Chair Genetic Immunotherapy, University Regensburg, 93053 Regensburg, Germany; Leibniz Institute for Immunotherapy, Div. Functional Immune Cell Modulation, University Regensburg, 93053 Regensburg, Germany; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Department of Biophysics and Cell Biology, University of Debrecen Faculty of Medicine, 4032 Debrecen, Hungary; University of Debrecen Faculty of Pharmacy, 4032 Debrecen, Hungary
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