医学
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Icosapent ethyl activates GPR120 to improve post-myocardial infarction cardiac remodeling by suppressing CXCR3+ inflammatory cells
作者Lu Liu; Wenhui Niu; Yumeng Jia; Qun Zhang; Tangyu Dai; Dingwei Li; Shuang Song; Yan Ma; Jingjing Wang; Huanling Yu; Guoyou Liu; Jie Du; Lei Wang
作者单位Department of Nutrition and Food Hygiene, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing 100069, China; Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing 100730, China; National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China; Department of Laboratory Animals, Capital Medical University, Beijing 100069, China; Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Institute for Biological Therapy, Henan Academy of Medical Science, Zhengzhou, Henan 451163, China; Beijing Anzhen Hospital, Capital Medical University; The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education; Beijing Collaborative Innovative Research Center for Cardiovascular Diseases; Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China; The Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing 100029, China
Novel Wnt potentiators induce iPSC-derived cardiomyocyte proliferation and increase embryonic zebrafish heart size
作者Daniela T. Asenjo; Lynn A.C. Devilée; Aaron H. Wasserman; Sitthixai Vongdeuane; Leif R. Neitzel; Benjamin Xu; Richard J. Mills; Charles H. Williams; James Hudson; Ruya Liu; Charles C. Hong
作者单位Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; QIMR Berghofer, Brisbane, QLD, Australia; Department of Medicine, Michigan State University College of Human Medicine, East Lansing, MI, USA; Henry Ford Health + Michigan State Health Sciences, Detroit, MI, USA; Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia; Novo Nordisk Foundation Center for Stem Cell Medicine, Murdoch Children's Research Institute, Melbourne, Victoria, Australia
TMEM175 deficiency impairs autophagic degradation and alleviates mitochondrial oxidative damage in cardiomyocytes through AMPK activation
作者Qingliu Li; Nan Hu; Limei Zhao; Shaoxuan Zhang; Lulu Meng; Jinyu Zhou; Qiujie Li; Fucheng Lei; Xiaotong Yang; Meiqin Hu; Hua Zhu; Pengzhou Hang; Jing Zhao
作者单位Department of Pharmacy, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital, Yangzhou, China; Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Suzhou Medical College of Soochow University, Suzhou, China; Department of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
PP2Acα regulates the Hippo-YAP signaling axis to promote cardiac regeneration and alleviate myocardial infarction
作者Anhui Wang; Boyang Qin; Mick Chang Jie Lee; Yike Zhu; Chang Wang; Rui Wang; Chuanfen Liu; Roger Foo; Rong Qi
作者单位Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China; Cardiovascular Metabolic Disease Translational Research Programme, National University of Singapore Yong Loo Lin School of Medicine, National University Health System, Centre for Translational Medicine, 14 Medical Drive, Singapore 117599, Singapore; Department of Cardiology, Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Center for Cardiovascular Translational Research, Peking University People's Hospital, Beijing 100044, China; Xinjiang Key Laboratory of Lavender Conservation and Utilization, College of Biological Sciences and Technology, Yili Normal University, Yining, Xinjiang 835000, China; Beijing Key Laboratory of Advanced Pharmaceutical Preparation, Peking University, Beijing 100191, China; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing 100191, China
Loss of Miro1 drives cardiac and mitochondrial dysfunction exacerbated by metabolic stress
作者Sarah Kassab; Zainab Albalawi; Asim M. Khojah; Connor D. Stonall; Wei Liu; Florence Baudoin; Sukhpal Prehar; Hind Almalki; Yoshimi Tokuyama; Gina Galli; Elizabeth J. Cartwright; Ashraf Kitmitto
作者单位Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, United Kingdom
Gfpt2 modulates fibroblast activation by glutathione metabolism
作者Paige Takasugi; Greg Farber; Luping Du; Shea N. Ricketts; Shay E. Rooney; Brian Spurlock; Haofei Wang; Jiandong Liu; Li Qian
作者单位Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; The McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cardiometabolic stress induces HFpEF with impaired bioenergetics and disrupted proteostasis in aged female mice
作者Kamil A. Kobak; Weronika Zarzycka; Catherine J. King; Frederick F. Peelor; Charlie Burnett; Willard M. Freeman; Kenneth M. Humphries; Benjamin F. Miller; Ying Ann Chiao
作者单位Aging and Metabolism Research Program, Oklahoma Medical Research Foundation , Oklahoma City , OK , USA; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Oklahoma City VA, Oklahoma City, OK, USA
Computational models show that functional remodeling, not anatomy, reshapes physiological determinants of cardiac performance in hypertrophic cardiomyopathy
作者Cristobal Rodero; Lara Curran; Christopher W. Lanyon; Paolo Inglese; Abdul Qayyum; Rosie K. Barrows; Jose A. Solis-Lemus; Shahrokh Rahmani; Marina Strocchi; Angela W.C. Lee; Tiffany M.G. Baptiste; Ludovica Cicci; Edward Burford; Elias Karabelas; Christoph M. Augustin; Gernot Plank; Richard D. Wilkinson; Antonio de Marvao; James S. Ware; Declan P. O'Regan; Sanjay K. Prasad; Steven A. Niederer
作者单位National Heart and Lung Institute (NHLI), Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK; School of Mathematical Sciences, University of Nottingham, Nottingham, UK; Biomedical Engineering Department, King's College London, London, UK; Cardiac Rhythm Management, Medtronic, London, UK; Institute for Mathematics and Scientific Computing, University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria; NumeriCor GmbH, Graz, Austria; Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria; Department of Women and Children's Health, King's College London, London, UK; British Heart Foundation Centre of Research Excellence, School of Cardiovascular & Metabolic Medicine and Sciences, King's College London, London, UK; The Alan Turing Institute, London, UK; Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford Univ., CA, USA
Beyond the N-terminus: Emerging regulatory roles of the middle and C-terminal domains of cardiac myosin binding protein-C
作者Garrett S. Crosby; Brett A. Colson; Carl W. Tong; Samantha P. Harris; Sakthivel Sadayappan
作者单位Department of Cellular and Molecular Medicine, Sarver Heart Center, University of Arizona College of Medicine, Tucson, AZ, United States of America; Advanced Heart Failure Section, Department of Medicine, Banner Health Tucson, Sarver Heart Center, University of Arizona College of Medicine, Tucson, AZ, United States of America; Department of Physiology, Sarver Heart Center, University of Arizona College of Medicine, Tucson, AZ, United States of America
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