医学
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10 篇有效样本 · 按发表日期由新到旧排列
审稿天数=录用日期-收稿日期;保留 PDF/DOI/网页源链接
Spatial atlas of upper tract urothelial carcinoma identifies SLC14A1 + and S100A8/9+ tumor cells as key determinants of malignant progression
作者Jiang Liu; Yangyang Wei; Yi Liu; Shiwei Sun; Diliyaer Dilixiati; Zhou Zhou; Xiangyun Lu; Ping Lu; Yang Zhao; YuShi Zhang
作者单位Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Department of International Medical Service (Xidan Campus), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Restoring lysosomal proteostasis reverses steatohepatitis and fibrosis in experimental MASH
作者Dylan Mastrippolito; Lauriane Gur; Malia Lasalo; Lara El Kaakour; Cindy Verdot; Franck Coste; Sébastien Blaise; Sylviane Muller
作者单位CNRS UMR7242, Biotechnology and cell signaling, University of Strasbourg, Strasbourg Drug Discovery and Development Institute (IMS), Strasbourg, France; CNRS UMR7369 Matrice Extracellulaire et Dynamique Cellulaire, University of Reims Champagne, Ardenne, Reims, France; CNRS UPR4301, Centre de Biophysique Moléculaire, Orléans, France; University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg, France
Drug leakage limits intratumoral drug exposure and efficacy: Influence of tumor mechanical heterogeneity
作者Kazuhiro Terai; Ryusho Kariya; Hiromi Ogata-Aoki; Mariko Ogura; Hiromitsu Iga; Satoshi Sakamoto; Seiji Sakano; Seiji Okada
作者单位One Time Energy Collaborative Laboratory, Institute of Industrial Nanomaterials, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan; Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan; Laboratory of Molecular Cellular Biology, School of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe 650-8586, Japan; R&D Headquarters & Life Science SBU, Tokyo Head Office, Daicel Corporation, 2-18-1 Konan, Minato-ku, Tokyo 108-8230, Japan
Metabolic syndrome identifies a high-risk polypharmacy phenotype in older adults with syncope
作者Susanna Longo; Stefano Rizza; Jose Manuel Fernández-Real; Massimo Federici
作者单位Department of Systems Medicine and Center for Atherosclerosis, University of Rome Tor Vergata, Rome, Italy; Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona, Spain; Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain; IRCCS Neuromed, Pozzilli (IS), Italy
Site and mechanism of BK channel inhibition and cerebral artery constriction by pregnenolone
作者Kelsey C. North; Shiwani Thapa; Steven C. Mysiewicz; Andrew A. Shaw; Gregg E. Homanics; Anna N. Bukiya; Alex M. Dopico
作者单位Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA; Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Schisandrin B protects against oxaliplatin-induced liver injury by suppressing ferroptosis via the canonical KEAP1-Nrf2 and non-canonical microbiota-driven Lactobacillus reuteri–CLA–Nrf2 axes
作者Ping Huang; Shan Li; Yichen Liu; Jinying Li; Bingchen Liu; Na Li; Cheng Wang; Chunhua Xia; Fanglan Liu
作者单位School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330006, PR China; Jiangxi Province Key Laboratory of New Drug Evaluation and Transformation, Nanchang 330031, PR China
Persistent molecular scars and gut-brain axis remodeling after acute DSS colitis
作者Federica Comella; Chiara Gualtieri; Cristina Travelli; Lorena Coretti; Marta Filibian; Nicola Opallo; Veronica Quaranta; Claudio Pirozzi; Stefania Melini; Alessia D’Andrea; Marco Racchi; Stefano Govoni; Carla Ghelardini; Lorenzo Di Cesare Mannelli; Luigia Trabace; Anna Pittaluga; Francesca Lembo; Rosaria Meli; Giuseppina Mattace Raso; Cristina Lanni
作者单位Department of Pharmacy, School of Medicine, University of Naples "Federico II”, Naples, Italy; Department of Drug Sciences, University of Pavia, Pavia, Italy; Task Force on Microbiome Studies, University of Naples "Federico II”, Naples, Italy; INFN, Istituto Nazionale di Fisica Nucleare-Pavia Unit, Pavia, Italy; Centro Grandi Strumenti, University of Pavia, Istituto Nazionale di Fisica Nucleare-Pavia Unit, Pavia, Italy; Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA, Pharmacology and Toxicology Section, University of Florence, Florence, Italy; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; Department of Pharmacy, University of Genoa, Genoa, Italy; Centro 3R (Inter-University Center for the Promotion of the 3Rs Principles in Teaching and Research), Italy
Metabolic–epigenetic vulnerability in cardiometabolic HFpEF: One-carbon metabolism, DNMT maintenance, and methylation instability
作者Weichen Luo; Wenjie Zuo; Yang Xu; Mingming Yang; Zhenjun Ji; Genshan Ma
作者单位Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China
Systematic screening identifies USP20 as an accelerator of metabolic dysfunction-associated steatotic liver disease via driving de novo lipogenesis
作者Xiaoxuan Ma; Weiwei Qin; Zian Feng; Nengneng Luan; Ruru Pan; Yanyan Diao; Zequn Yin; Suowen Xu; Junbo Ge; Shuang Zhang; Yajun Duan
作者单位Department of Cardiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, China; Innovation Center for AI and Drug Discovery, School of Pharmacy, East China Normal University, Shanghai 200062, China; East China University of Science and Technology, Shanghai, China; Department of Endocrinology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China; NHC Key Laboratory of Ischemic Heart Diseases, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China; College of Food and Biological Engineering, Hefei University of Technology, Hefei, China
Oncolytic virus-delivered CEACAM6/CD3 BiTEs combine with PD-1 blockade to achieve synergistic anticancer efficacy
作者Weiwei Zhang; Shuang Dai; Haohan Fan; Nian Yang; Long Xu; Zheran Liu; Yu Min; Zheng Jiang; Liangxue Zhou; Hui Yang; Aiping Tong; Xingchen Peng
作者单位Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China; Department of Oncology, Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, Sichuan Province 610041, China; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China; Department of Neurosurgery, NHC Key Laboratory of Nuclear Technology Medical Transformation(Mianyang Central Hospital), School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan Province 621000, China; Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, Sichuan Province 610212, China; Nuclear Physics and Medical Research Key Laboratory of Sichuan Province, Sichuan University, Chengdu, Sichuan Province 610041, China
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