生物学
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High-level terpene production via a novel Actinomycetota-derived MVA pathway in E. coli
作者Wenchao Liu; Xueying Tian; Wai Chuen Wong; Zhihong Guo; Xin Huang; Jian-Wei Tang; Pei-Yuan Qian
作者单位Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China; Department of Ocean Science and Otto Poon Center for Climate Resilience and Sustainability, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Emerging Interdisciplinary Areas, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Department of Chemistry, Department of Physics, and Bioengineering Program, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
Unlocking microbial access to amino-substituted 4-hydroxycoumarin derivatives via enzymatic promiscuity and metabolic engineering
作者Caiyi Zhao; Jingqi Hou; Daphne Huang; Cholapat Varongchayakul; Nuojin Cheng; Yilin Li; Chenyi Li; Jay D. Keasling
作者单位Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Joint BioEnergy Institute, Emeryville, CA, USA; College of Chemistry, University of California, Berkeley, CA, USA; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA, USA; Department of Chemical & Biomolecular Engineering, University of California, Berkeley, CA, USA; Department of Bioengineering, University of California, Berkeley, CA, USA
Engineering Escherichia coli to modulate hydrogen sulfide levels using insights from intestinal sulfur metabolism
作者Justin A. Hayes; Brent Buchinger; Anna W. Lunger; Tanvi Khanvilkar; William Gasparrini; Matthew T. Fernez; Madeleine Morrissette; Philip Strandwitz; Abigail N. Koppes; Ryan Koppes; Benjamin M. Woolston
作者单位Department of Chemical Engineering, Northeastern University, 360 Huntington Ave., Boston, MA, 02115, USA; Holobiome Inc., 650 Albany St., Boston, MA, 02118, USA; Department of Bioengineering, Northeastern University, 360 Huntington Ave., Boston, MA, 02115, USA; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Ave., Boston, MA, 02115, USA
Alleviating the Crabtree effect for high-level production of squalene in Saccharomyces cerevisiae
作者Shuyan Tang; Wenzhuo Gao; Jiaying Wang; Dongzhi Wei; Feng-Qing Wang
作者单位State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, P.O. Box 311, 130 Meilong Road, Shanghai, 200237, China
Engineering TPT1-mediated apoptosis resistance for improved mammalian cell biomanufacturing
作者Javier Bravo-Venegas; Zeynep Betts; Devika Kalsi; Leon P. Pybus; Camila A. Orellana; Claudia Altamirano; Alan J. Dickson; Mauro Torres
作者单位Department of Chemical Engineering, University of Manchester, Manchester, UK; Manchester Institute of Biotechnology, University of Manchester, Manchester, UK; School of Biochemical Engineering, Pontificia Universidad Católica de Valparaiso, Valparaiso, Chile; FUJIFILM Biotechnologies, Billingham, TS23 1LH, UK; Department of Chemical and Bioprocess Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile; Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, 7820436, Chile; Center for Interdisciplinary Research in Biomedicine, Biotechnology and Well-Being (CID3B). Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile; IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile; School of Chemical Engineering, The University of Queensland, Brisbane, Australia
Metabolic engineering of Rhodococcus aromaticivorans RHA1 for muconic acid production from lignin
作者Anne T. Lalande; Logan D. Robeck; Dillon T. Hofsommer; Lucie C.L. Lippuner; Shannon S. Stahl; Lindsay D. Eltis
作者单位Department of Microbiology and Immunology, Life Sciences Institute and Bioproducts Institute, The University of British Columbia, Vancouver, BC, Canada; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Energy Institute, University of Wisconsin-Madison, Madison, WI, USA
Alcohol dehydrogenase-mediated methanol dissimilation increases carbon efficiency in synthetic autotrophic yeast
作者Charles Moritz; Lisa Lutz; Michael Baumschabl; David Glinsner; Thomas Gassler; Diethard Mattanovich; Özge Ata
作者单位BOKU University, Institute of Microbiology and Microbial Biotechnology, Department of Biotechnology and Food Science, Vienna, Austria; Austrian Centre of Industrial Biotechnology (acib), Vienna, Austria
Engineering a versatile Aspergillus niger platform for efficient and scalable biosynthesis of polyketides
作者Linlin Yao; Rui Huang; Jiaping Liu; Bin Wang; Li Pan
作者单位School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China; Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou, China
Metabolic engineering of Taxus chinensis suspension cell lines for overproduction of paclitaxel reveals insights into pathway regulation
作者Cassandra Brzycki Newton; Michelle C. McKee; Alexandra M. Harrison; Lauren D. Revene; Taylor Fiore; Antonio M. Sassano; Eric M. Young; Susan C. Roberts
作者单位Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, MA, 01609, USA; Department of Chemical Engineering, University of Massachusetts, Lowell, MA, 01854, USA
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