生物学
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Col4a1 mutation in a mouse model of cerebral small vessel disease causes white matter defects that can be modulated by targeting protein folding
作者Gaia Brezzo; Alexandra Pokhilko; Jon Moss; Juraj Koudelka; Maurits A. Jansen; Ross Lennen; Gerry Thompson; Nela Fialova; Sofia Marina Konstantinidou; Joyce Yau; Erin Boland; Anna Williams; Stuart M. Allan; Alessandra Granata; Sanjay Sinha; Tao Wang; Hugh S. Markus; Roman Fischer; M. Zameel Cader; Tom Van Agtmael; Karen Horsburgh
作者单位Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Chancellor’s Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK; School of Cardiovascular and Metabolic Health, University of Glasgow, University Avenue, Glasgow, G12 8QQ, United Kingdom; UK Dementia Research Institute, University of Edinburgh, Edinburgh, EH16 4SB, UK; Translational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DS, United Kingdom; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, EH16 4UU, UK; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, United Kingdom; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK; Stroke Research Group, Department of Clinical Neurosciences Department, University of Cambridge, Cambridge, UK; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, United Kingdom; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, United Kingdom; Discovery Proteomics Facility, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, United Kingdom; Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Regulators of ECM structure enable functional adaptation to tensile loading in tendon explants
作者Emma J. Stowe; Brianne K. Connizzo
作者单位Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States; Department of Mechanical Engineering, Boston University, Boston, MA 02215, United States
Airway macrophage specific glycocalyx expression and remodeling following viral infection
作者Ziyun Zhang; Iashia Z Nabi; Samie Dalgarno; H. Davies-Strickleton; Ilayda Akbulut; Tracy Hussell; Douglas P Dyer
作者单位Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom; Manchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Manchester, United Kingdom
Oligodendrocyte integrin-β1 regulates blood-brain barrier and remyelination in hemorrhagic brain
作者Mehran Shaban Pour; Adil Moula; Ava Nasrollahi; Minkyung Kang; Yao Yao
作者单位Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Department of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, USA
Tenascin‑C promotes epidural fibrosis via regulating caveolin-1-mediated TGFβRI internalization
作者Zeyuan Song; Yue Huang; Youpeng Zhao; Tao Zhu; Mohan Shi; Jinpeng Sun; Mingshun Zhang; Jun Liu
作者单位Department of Orthopedics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China; NHC Key Laboratory of Antibody Technique, Jiangsu Province Engineering Research Center of Antibody Drug, Department of Immunology, Nanjing Medical University, Nanjing, China
Loss of type III collagen has limited effect on tendon healing in young adult mice
作者Margaret K. Tamburro; Jaclyn A. Carlson; William K. Yen; Stephanie N. Weiss; Emma E. Kroll; Miranda K. Doro; Courtney A. Nuss; Mengcun Chen; Daniel C. Stewart; Jeremy D. Eekhoff; Louis J. Soslowsky; Susan W. Volk
作者单位McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, PA, USA; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA; Department of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
C-terminally clustered UGDH hypomorphic variants reveal subtle mechanisms of cellular and developmental disruption
作者Hali Harwood; Brenna M. Zimmer; Asher R. Utz; Myrrhe Venema; Emily Allego; Sydney S. Skirboll; Autumn Harding; Jeffrey R. Enders; Sarah Grantham-Hill; Frances Elmslie; Yong-Ru Ly; Antonia Clarke; Maria Xu; Hui Jeen Tan; Karen Stals; Saumya Shekhar Jamuar; Tahsin Stefan Barakat; Thomas M. Makris; Joseph J. Barycki; Melanie A. Simpson
作者单位Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA; Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Molecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC 27695, USA; South West Thames Centre for Genomics, St George’s University Hospitals NHS Foundation Trust, London, UK; Synnovis Biochemical Genetics, Guy’s Hospital, London, UK; Department of Paediatric Neurology, St George’s University Hospitals NHS Foundation Trust, London, UK; Manchester Centre for Genomic Medicine, Manchester, UK; Department of Paediatric Neurology, Royal Manchester Children’s Hospital, Manchester, UK; Exeter Genomics Laboratory, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Genetics service, KK Women’s and Children’s Hospital, Singapore
Cytokine conversations: Fibroblasts shape macrophage identity to enhance collagen clearance
作者Signe Spliid Heltberg; Sander van Putten; Oliver Krigslund; Kirstine Sandal Nørregaard; David Højland Ipsen; Niels Behrendt; Lars Henning Engelholm; Henrik Jessen Jürgensen
作者单位The Finsen Laboratory, Copenhagen University Hospital, DK-2200 Copenhagen, Denmark; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Novo Nordisk A/S, LEAD Pharmacology, DK-2760 Måløv, Denmark
Heparan sulfate buffers the bone resorptive activity of Cathepsin K in bone homeostasis
作者Yin Luo; Xiaoxiao Zhang; Huanmeng Hao; Zhangjie Wang; Jian Liu; Ding Xu
作者单位Department of Oral Biology, School of Dental Medicine, University at Buffalo, the State University of New York, USA; Department of Orthopaedics, School of Medicine, Emory University, USA; Glycan Therapeutics Corporation, Raleigh, NC, USA; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA
Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro
作者Hiroki Machida; Jun Yokota; Hironobu Fujiwara
作者单位Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe 650-0047, Japan; Graduate School of Medicine, The University of Osaka, Suita 565-0871, Japan
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