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Impaired glycoRNA biogenesis in metabolic-dysfunction associated steatotic liver disease
作者Chengji Dong; Xiaowei Zhong; Qi Peng; Zoe Müller; Julia Beimdiek; Katrin Splith; Linda Feldbrügge; Tobias Cantz; Manvendra K. Singh; Falk F.R. Buettner; Heike Bantel; Heiner Wedemeyer; Michael Ott; Asha Balakrishnan; Amar Deep Sharma
作者单位Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Research Group RNA Therapeutics & Liver Regeneration, Research Center for Translational Regenerative Medicine, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Institute of Clinical Biochemistry, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, 8 College Road, Office 08-15, Singapore 169857, Singapore; Proteomics Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätsstrasse 2, 86159, Augsburg, Germany
Liver-directed lentiviral gene therapy confers durable hepatic and systemic amelioration of methylmalonic acidemia in mice
作者Elena Barbon; Chiara Simoni; Amy Argabright; Molly Boettiger; Camilla Negri; Elisabetta Manta; Andrea Raimondi; Elena Vezzoli; Cesare Canepari; Mauro Biffi; Alessandro Nonis; Francesco Gazzo; Fabrizio Benedicenti; Eugenio Montini; Giancarlo la Marca; Francesca Sanvito; Julianne Smith; Angelo D’Alessandro; Alessio Cantore
作者单位San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; ALEMBIC Advanced Light and Electron Microscopy BioImaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy; Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy; Newborn Screening, Clinical Biochemistry and Clinical Pharmacy Lab Meyer Children's Hospital IRCCS, Florence, Italy; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy; IRCCS San Raffaele Scientific Institute, Milan, Italy; Genespire S.r.l., Milan, Italy
siRNA JNJ-73763989 decreases HBsAg and HDV RNA in NA-treated hepatitis D patients but may cause ALT flares
作者Heiner Wedemeyer; Ed Gane; Kosh Agarwal; Ömer Fehmi Tabak; Xavier Forns; Ulus Salih Akarca; Viacheslav Morozov; Soo Aleman; Maria Buti; Gurdal Yilmaz; Pietro Lampertico; John Jezorwski; Thomas N. Kakuda; Adam Bakala; Nonko Pehlivanov; Thierry Verbinnen; Oliver Lenz; Michael Biermer
作者单位Department of Gastroenterology, Hepatology, Infectious Diseases, and Endocrinology, Hannover Medical School, Hanover, Germany, Excellence Cluster RESIST, D-SOLVE Consortium, Hannover, German Center for Infection Research (DZIF) Partner Site Hannover-Braunschweig, Braunschweig, Germany; New Zealand Liver Transplant Unit, University of Auckland, Auckland, New Zealand; Institute of Liver Studies, King’s College Hospital, London, England; Istanbul University-Cerrahpasa, Department of Infectious Diseases, Istanbul, Turkey; Liver Unit, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, CIBEREHD, Spain; Division of Gastroenterology, Department of Internal Medicine, Ege University Medical Faculty, Izmir, Turkey; Medical Company Hepatolog Ltd, Samara, Russia; Department of Infectious Diseases, Karolinska University Hospital/Karolinska Institutet, Stockholm, Sweden; Hospital General Universitari Valle Hebron and CIBER-EHD del Instituto Carlos III, Barcelona, Spain; Trabzon Karadeniz Technical University Farabi Hospital, Trabzon, Turkey; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; CRC “A. M. and A. Migliavacca” Center for Liver Disease, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Johnson & Johnson, Titusville, NJ, USA; Johnson & Johnson Research & Development, LLC, Brisbane, CA, USA; Johnson & Johnson, Beerse, Belgium
Rifaximin ameliorates cirrhotic portal hypertension through suppression of microbiome-derived deoxycholic acid
作者Hai-Lin Xiong; Qi Zhao; Shu-Qing Liu; Li-Lin Chen; Mei-Tong Nie; Xia-Lu Hong; Chen-Hong Ding; Ru Huang; Nan Jiang; Fei Chen; Yu-Hao Song; Xin Zhang; Ke-Qi Wang; Chang-Peng Zhu; Wei-Fen Xie
作者单位Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China; Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China; Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
Arachidonoyl-taurine is elevated in human MASLD and protects against hepatic steatosis and inflammation in preclinical models
作者Katharina B. Kuentzel; Samuel A.J. Trammell; Anna S. Hassing; Ivan Bradić; Michelle Damgaard; Emma B. Fals; Katja T. Michler; Matthew Dooley; Jens C.B. Jacobsen; Malte P. Suppli; Mikkel P. Werge; Cameron J. Mitchell; Nicolai J. Wewer Albrechtsen; Lise L. Glud; Filip K. Knop; James F. Markworth; Martin R. Larsen; Matthew P. Gillum; Jonas T. Treebak; Jesmund Dalli; Steen Larsen; Trisha J. Grevengoed
作者单位Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Department of Clinical Biochemistry, Copenhagen University Hospital—Bispebjerg, Copenhagen, Denmark; Gastro Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; School of Kinesiology, The University of British Columbia, Canada; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Present address: Novo Nordisk, Bagsværd, Denmark; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA; Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, UK; Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Denmark; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
A multi-analyte cfDNA-based blood test for early detection of hepatocellular carcinoma
作者David J. Taggart; Shivani Mahajan; Maxime A. Gallant; Itai Pinkoviezky; Jianfeng Xu; Allison J. Sorg; Curt C. Roberts; Dmitri Slinkov; Emmanuel C. Gorospe; Abdullah Mubarak; Bal Raj Bhandari; Bradley Freilich; Nadege Gunn; Ju Dong Yang; John H. Smith; Ziad H. Younes; Roniel Cabrera; Humberto Aguilar; Hrishikesh Samant; Wei Li; Richard A. Van Etten; Mindie H. Nguyen
作者单位Helio Genomics, Inc., Irvine, California, USA; Laboratory for Advanced Medicine & Health Ltd. (LAMH), Beijing, China; Texas Gastro Research, El Paso, Texas, USA; Liver Center of Texas, Dallas, Texas, USA; Delta Research Partners, LLC, Bastrop, Louisiana, USA; Kansas City Research Institute, Kansas City, Missouri, USA; Velocity Clinical Research, Waco, Texas, USA; Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California, USA; Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA; Digestive and Liver Disease Specialists, Norfolk, VA, USA; Gastro One, Germantown, Tennessee, USA; Division of Gastroenterology, Hepatology, and Nutrition, College of Medicine, University of Florida, Gainesville, Florida, USA; Louisiana Research Center, Shreveport, Louisiana, USA; Department of Gastroenterology and Hepatology, Ochsner Health System, New Orleans, Louisiana, USA; Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, California, USA; Chao Family Comprehensive Cancer Center and Department of Medicine, School of Medicine, University of California, Irvine, California, USA; Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, California, USA; Department of Epidemiology and Population Health, Stanford University Medical Center, California, USA; Stanford Cancer Institute, Stanford University Medical Center, California, USA
CD34+ cell-derived endothelial cells orchestrate vascular and immune remodeling in the transplanted liver
作者Ruihan Chen; Xinqiang Li; Pengwei Zhu; Xuewen Yi; Ting Wang; Hui Chen; Xueyin Huang; Guoguo Ye; Jingyu Jiang; Meiching Ong; Liujun Jiang; Yali Li; Siyi Zhong; Yangyan He; Rong Fan; Bohuan Zhang; Hongjun Li; Jinzhen Cai; Shusen Zheng; Qingbo Xu; Qi Ling; Hongkun Zhang
作者单位Department of Vascular Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Organ Transplantation Center, Affiliated Hospital of Qingdao University, Qingdao, China; Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou, China; Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou, China; National Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China; Liangzhu Laboratory, Zhejiang University, Hangzhou, China; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Tim-3 facilitates dendritic cell ferroptosis and impairs antitumor immunity in steatohepatitis-related HCC
作者Na Li; Xiaojia Song; Xueqi Peng; Mengzhen Li; Mengyao Zhu; Rong Xiao; Liwen Wang; Leyan Ling; Ying Zhao; Tixiao Wang; Zhiyuan Zhou; Zhuanchang Wu; Hua Tang; Lifen Gao; Xiaohong Liang; Chunyang Li; Chunhong Ma
作者单位Key Laboratory for Experimental Teratology of Ministry of Education, Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Shandong University Cancer Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Institute of Infection and Immunity, Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250012, China; Key Laboratory for Experimental Teratology of Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University, Jinan, Shandong 250012, China; Department of Radiation Oncology, Shandong Provincial Key Laboratory of Precision Oncology, Shandong University Cancer Center, Jinan, Shandong 250012, China; Department of Clinical Laboratory, Qilu Hospital, Shandong University (Qingdao), Qingdao, China
Single-nucleus profiling reveals hepatocyte identity and immune features associated with corticosteroid response in severe alcohol-related hepatitis
作者Lukas Van Melkebeke; Markus Boesch; Tessa Ostyn; Wenxin Huang; Cansu Akkaya; Matthias van Sligtenhorst; Dania El Abyad; Fateme Safaeifard; Alexander Dumarey; Marie Wallays; Bram Boeckx; Rita Feio-Azevedo; Lena Smets; Thierry Gustot; Eric Trépo; Christophe Moreno; Antonella Putignano; Luc Lasser; Isabelle Colle; Pierre Deltenre; Astrid Marot; Baki Topal; Eveline Claus; Lawrence Bonne; Geert Maleux; Colinda Scheele; Tim Hendrikx; Frederik Nevens; Hannelie Korf; Tania Roskams; Alexandre Denadai-Souza; Diether Lambrechts; Olivier Govaere; Schalk Van der Merwe; Jef Verbeek
作者单位Laboratory of Liver Immunology, Hepatology Research Unit, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; KU Leuven Institute for Single Cell Omics, KU Leuven, Leuven, Belgium; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium; Laboratory of Mucosal Biology, Hepatology Research Unit, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium; Laboratory for Intravital Imaging and Dynamics of Tumor Progression, VIB Center for Cancer Biology, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium; Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology, Leuven, Belgium; Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium; Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium; Department of Hepatogastroenterology, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium; Department of Gastroenterology and Hepatology, A-Zorg campus Merestraat, Aalst, Belgium; Department of Gastroenterology and Hepatology, Clinique St-Luc, Bouge, Belgium; Department of Gastroenterology, Hepatology and Digestive Oncology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium; Department of Gastroenterology and Hepatology, CHU UCL Namur, Université Catholique de Louvain, Yvoir, Belgium; Department of Abdominal Surgery, University Hospitals Leuven, Leuven, Belgium; Department of Interventional Radiology, UZ Leuven, Leuven, Belgium; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
Fusobacterium nucleatum alleviates alcohol-associated liver disease through mannose-mediated elevation of Fbp1 and modulation of gut microbiota
作者Hang Shu; Dongqing Wu; Linxi Xie; Gaoyuan Wang; Hang Zhou; Hejiao Zhang; Shanfei Tian; Xinru Zhang; Chunfeng Li; Chenyu Wang; Liangliang Zhou; Lei Yang; Qiang Hu; Xiaoli Wei; Haiyuan Shen; Long Xu; Hua Wang
作者单位Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Key Laboratory of Anti-inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Hefei, China; School of Basic Medical Sciences, Anhui Medical University, Hefei, China; Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University, Hefei, China; Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Infectious Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
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