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PRACTALL 2025: Artificial intelligence—application of allergy and immunology to patient care
作者Mohamed M. Shamji; Nicholas L. Rider; Ian Adcock; Thanai Pongdee; Stefano Del Giacco; Christopher Chang; Maria Jose Torres Jaén; Paul V. Williams
作者单位National Heart and Lung Institute, Imperial College London, London, United Kingdom; NIHR Imperial Biomedical Research Centre, London, United Kingdom; Frankland and Kay Allergy Centre, Imperial College London, London, United Kingdom; Department of Health Systems and Implementation Science, Virginia Tech Carilion School of Medicine, Roanoke, Va; Section of Allergy and Immunology, Department of Pediatrics, The Carilion Clinic, Roanoke, Va; Division of Allergic Diseases, Mayo Clinic, Rochester, Minn; Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy; Division of Immunology, Allergy and Pediatric Rhematology, Memorial Healthcare System, Joe DiMaggio Children’s Hospital, Hollywood, Fla; Instituto de Investigación Biomédica de Málaga (IBIMA-Plataforma BIONAND), Málaga, Spain; Department of Environmental Health, University of Washington, Seattle, Wash; Department of Pediatrics, University of Washington, Seattle, Wash
Dupilumab outcomes in pediatric asthma by early eosinophil status: Post hoc analysis of VOYAGE/EXCURSION
作者Sharon Dell; Theresa W. Guilbert; Antoine Deschildre; Wanda Phipatanakul; Nikolaos G. Papadopoulos; Clare S. Murray; Changming Xia; Andrew Moraco; Marissa Shams; Leonard B. Bacharier
作者单位Pediatric Respiratory Medicine, BC Children’s Hospital, Vancouver, British Columbia, Canada; University of British Columbia, Vancouver, British Columbia, Canada; Cincinnati Children’s Hospital and University of Cincinnati, Cincinnati, Ohio; CHU Lille, Université de Lille, and Pediatric Pulmonology and Allergy Department, Hôpital Jeanne de Flandre, Lille, France; Department of Allergy and Immunology, Boston Children’s Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass; National and Kapodistrian University of Athens, Athens, Greece; University of Manchester, Manchester, United Kingdom; Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Regeneron Pharmaceuticals Inc, Tarrytown, NY; Sanofi, Cambridge, Mass; Division of Allergy, Immunology and Pulmonary Medicine, Monroe Carell Jr. Children’s Hospital at Vanderbilt University Medical Center, Nashville, Tenn
Practice parameter for inborn errors of immunity: What is new in the 2025 update
作者Javier Chinen; Catherine C. Horner; Jordan S. Orange
作者单位Division of Immunology, Allergy and Retrovirology, Department of Pediatrics, Baylor College of Medicine, Houston, Tex; Division of Allergy, Immunology and Pulmonology, Department of Pediatrics, Washington University, St Louis, Mo; Division of Allergy and Immunology, Department of Pediatrics, University of Pennsylvania, Philadelphia, Pa
Multicytokine-based transcriptome-wide association study for 7 inflammatory skin disorders identifies candidate causal genes in keratinocytes
作者Haihan Zhang; Matthew T. Patrick; Mrinal K. Sarkar; Rachael Bogle; Qinmengge Li; Ranjitha Uppala; Bethany E. Perez White; Lynn Petukhova; Nick Dand; Philip E. Stuart; Angela M. Christiano; Michael A. Simpson; Jonathan N. Barker; Stephan Weidinger; Robert L. Modlin; Regina C. Betz; Dinesh Khanna; John Varga; J. Michelle Kahlenberg; Kevin He; James T. Elder; Xiang Zhou; Johann E. Gudjonsson; Lam C. Tsoi
作者单位Department of Biostatistics, University of Michigan, Ann Arbor, Mich; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Mich; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Ill; Department of Dermatology, Grossman School of Medicine, New York University, New York, New York; Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King’s College London, London, United Kingdom; Department of Dermatology, Columbia University, New York, New York; St John’s Institute of Dermatology, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom; Department of Dermatology, University Hospital, Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany; Department of Internal Medicine, Division of Dermatology, University of California, Los Angeles, Calif; Institute of Human Genetics, University of Bonn, Medical Faculty & University Hospital Bonn, Bonn, Germany; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Mich; Taubman Medical Research Institute, University of Michigan Medical School, Ann Arbor, Mich; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Mich; Department of Statistics and Data Science, Yale University, New Haven, Conn; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Mich
Early intervention with secukinumab prevents epigenetic scar development in new-onset psoriasis: STEPIn mechanistic substudy results
作者Johann E. Gudjonsson; Katharina Bier; Swann Gaulis; Lam C. Tsoi; Mathias Cardner; Mrinal K. Sarkar; Anthony Coon; Christopher Cole; Jaanika Kärner; Anita Fernandez; Thomas Peters; Liv Eidsmo; Lars Iversen; Piotr Jagiello; Enrico Ferrero; Frank Kolbinger; Felix Lohmann; Curdin Conrad
作者单位University of Michigan, Ann Arbor, Mich; Novartis Biomedical Research, Basel, Switzerland; Novartis Pharma AG, Basel, Switzerland; Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Gastro/Hud/Reuma, Karolinska University Hospital, Stockholm, Sweden; Aarhus University, Aarhus, Denmark; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, Lausanne, Switzerland
One-year clinical remission with tezepelumab in severe asthma: TERESA single-arm prospective study
作者Keiko Kan-o; Hiroko Watanabe; Kenji Chibana; Maho Suzukawa; Akihiko Tanaka; Katsunori Masaki; Shin Ohta; Hiroki Kabata; Koichiro Asano; Reiko Ito; Hiromasa Inoue; Takako Nakano; Hideki Kanda; Takafumi Yamashita; Yasushi Obase; Konomi Kobayashi; Naoya Sugimoto; Yoko Ito; Hiroaki Ogata; Koichi Takagi; Nobuharu Ohshima; Takashi Kinoshita; Hiroki Tashiro; Koichiro Takahashi; Keiji Oishi; Tsunahiko Hirano; Hideki Sakakibara; Konomi Sennari; Yukihiro Sugimoto; Takayuki Shiroyama; Susumu Fukahori; Tsuyoshi Oguma; Katsuyoshi Tomomatsu; Sho Shimada; Mitsuko Kondo; Tomohiro Akaba; Michihiro Yoshimi; Yuki Moriuchi; Mari Ujike; Miho Mitsui; Kaoruko Shimizu; Yuichiro Shindo; Seiko Takasawa; Keiko Wakahara; Tomoki Uno; Jun Miyata; Akane Ishida; Mayoko Tsuji; Akikazu Shimada; Isamu Okamoto
作者单位Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Respiratory Medicine, Tokyo Women’s Medical University, Tokyo, Japan; Department of Statistics and Data Center, Clinical Research Support Center Kyushu, Fukuoka, Japan; Department of Pulmonary Medicine, National Hospital Organization Okinawa Hospital, Okinawa, Japan; Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Tokyo, Japan; Department of Medicine, Division of Respiratory Medicine and Allergology, Showa Medical University School of Medicine, Tokyo, Japan; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan; Division of Respiratory Medicine, Nihon University School of Medicine, Tokyo, Japan; Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan; Department of Respiratory Medicine, National Hospital Organization Fukuokahigashi Medical Center, Fukuoka, Japan; Department of Respiratory Medicine, University of Occupational and Environmental Health, Fukuoka, Japan; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan; Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan; Department of Respiratory Medicine, NHO Fukuoka National Hospital, Fukuoka, Japan; Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan; Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University Hospital, Saga, Japan; Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan; Department of Respiratory Medicine, Fukuoka Seisyukai Hospital, Fukuoka, Japan; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan; Department of Respiratory Medicine, Institute of Science Tokyo Hospital, Tokyo, Japan; Infectious Diseases Treatment and Prevention Center, Department of Infectious Diseases, Nagasaki University Hospital, Nagasaki, Japan; Department of Respiratory Medicine, University of Fukui Hospital, Fukui, Japan; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Hokkaido, Japan; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan; Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan
Circulating extracellular vesicles drive innate immune dysregulation in MIS-C
作者Tugce Canavar Yildirim; Yasemin Ozsurekci; Muzaffer Yildirim; Volkan Yazar; Irem Evcili; Bilgi Gungor; Ismail Cem Yilmaz; Seza Ozen; Kubra Aykac; Ali Bulent Cengiz; Ulku Guler; Bekir Salih; Mayda Gursel; Ihsan Gursel
作者单位Vaccine Development Research Program, Dokuz Eylul University, Izmir Biomedicine and Genome Center, Izmir, Turkiye; Molecular Biology and Genetics Department, Bilkent University, Ankara, Turkiye; Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkiye; Department of Genomics and Molecular Biotechnology, Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkiye; Department of Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye; Department of Chemistry, Hacettepe University, Ankara, Turkiye
Homozygous loss-of-function mutation in SIT1 leads to combined immunodeficiency due to dysregulated T-cell receptor signaling
作者Pu Chen; Kim My Le; Weiwei Li; Francisca Hinrichsen; Xiaonan Liu; Ragnhild Selvig Braathen; Nanni Mamia; Monika Szymanska; Zhuokun Li; Luca Trotta; Henrikki Almusa; Katariina Mamia; Virpi Glumoff; Peter Holland; Simon Anders; Artem Kalinichenko; Meri Kaustio; Mikko R.J. Seppänen; Emma Maria Haapaniemi; Markku Varjosalo; Timi Martelius; Juha Grönholm; Janna Saarela
作者单位Norwegian Centre for Molecular Biosciences and Medicine (NCMBM), University of Oslo, Oslo, Norway; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland; Pediatric Research Center, New Children’s Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland; Institute of Biotechnology, University of Helsinki, Helsinki, Finland; Precision Immunotherapy Alliance, University of Oslo, Oslo, Norway; Department of Pediatrics, Oslo University Hospital, Oslo, Norway; Medical Research Laboratory Unit, Faculty of Medicine, University of Oulu, Oulu, Norway; Bioquant Center, University of Heidelberg, Heidelberg, Germany; Division of Immunology, Otto Loewi Research Center, Graz, Austria; Research Unit for Cancer and Inborn Errors of the Blood and Immunity in Children, Division of Pediatric Hematology-Oncology, Department of Pediatric and Adolescent Medicine, Medical University of Graz, Graz, Austria; Rare Diseases Center, New Children’s Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland; Adult Immunodeficiency Unit, Inflammation Center/Infectious Diseases, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland; Division of Hematology, Oncology, and Stem Cell Transplantation, New Children’s Hospital, HUS Helsinki University Hospital, Helsinki, Finland; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
HLA-B alleles confer susceptibility to sulfasalazine-induced severe cutaneous adverse reactions
作者Chuang-Wei Wang; Wei-Ti Chen; Chun-Bing Chen; Chia-Yu Chu; Rosaline Chung-Yee Hui; Chun-Wei Lu; Tsu-Man Chiu; Shuen-Iu Hung; Huang Yu Huei; Wichittra Tassaneeyakul; Siew-Eng Choon; Nontaya Nakkam; Chonlaphat Sukasem; Yeong-Jian Jan Wu; Hsin-Yu Chung; Jr-Hau Lung; Jeng-Shou Chang; Yun-Shien Lee; Ya-Ching Chang; Kuang-Hui Yu; Yu-Chuan Teng; Shang-Hung Lin; Kuo-Chu Lai; Hsin-Han Hou; Jennifer Wu; Min-Hui Chi; Hua-En Lee; Yang Yu-Wei Lin; Yu-Jr Lin; Wen-Hung Chung
作者单位Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung, Taiwan; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China; Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; hole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan; Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Hospital Sultanah Aminah, Clinical School Johor Bahru, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Johor Bahru, Malaysia; Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, Thailand; The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) research group; Division of Allergy, Immunology and Rheumatology, Department of Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan; Department of Medical Research and Development, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan; Division of Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan; Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Hematology and Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan; Graduate Institute of Oral Biology, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Research Services Center for Health Information, Chang Gung University, Taoyuan, Taiwan; Department of Dermatology, Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China; Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Associations of rurality, child opportunity, and distance with use of pediatric asthma specialists
作者James Bohnhoff; Anya Cutler; Elizabeth A. Jacobs; Wanda Phipatanakul; Yvonne Jonk
作者单位Department of Pediatrics, MaineHealth, Portland, Me; Center for Interdisciplinary Population and Health Research, MaineHealth Institute for Research, Scarborough, Me; Department of Pediatrics, Tufts University School of Medicine, Boston, Mass; Department of Internal Medicine, University of California, Riverside, Riverside, Calif; Department of Immunology, Harvard Medical School, Boston, Mass; Muskie School of Public Health, University of Southern Maine, Portland, Me
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