生物学
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10 篇有效样本 · 按发表日期由新到旧排列
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BRD2-Mediated TGR5 destabilization impairs fatty acid oxidation and drives tubular ferroptosis in diabetic kidney injury
作者Huimei Zang; Fucheng Zang; Haiyan Zhang; Yuxin Lei; Ying Jiang; Yuxiao Li; Dongqi Tang; Dan Wang; Fang Xiao
作者单位Center for Gene and Immunotherapy, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, No.247 Beiyuan Road, Jinan, 250033, China; Multidisciplinary Innovation Center for Nephrology of the Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, No.44 Wenhua West Road, Jinan, 250033, China; Department of Rehabilitation Medicine, Xuzhou Medical University, No.209 Tongshan Road, Xuzhou, 221004, China; Department of Nephrology, Jinan Central Hospital Affiliated to Shandong First Medical University, No.105 Jiefang Road, Jinan, 250033, China; Department of Gerontology, The Second Qilu Hospital of Shandong University, Shandong University, No.247 Beiyuan Road, Jinan, 250033, China
Metformin activates the mitochondrial unfolded protein response via the AMPK/SIRT1 pathway to delay intervertebral disc degeneration
作者Shanzhong Shao; Zhiwei Huang; Jinrun Liu; Jie Li; Ziyu Wang; Ruoyu Yang; Shengxuan Chang; Guoqing Bao; Ming Zhu; Songsen Gao; Shengquan Zhang; Sumei Zhang; Xiaochuan Li; Hui Tao
作者单位Department of Orthopedics and Spine Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Spinal Surgery, Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China; Department of Orthopedic Surgery, Gaozhou People's Hospital Affiliated to Guangdong Medical University, Gaozhou, China
Differential contribution of lipoxygenase isoforms to the sequential biosynthesis of specialized pro-resolving mediators in monocellular and cell co-incubations
作者Markus Werner; Bill J. Perkowski; Elena Brunner; Gregor Griebel; Lena Hegner; Sarah Klauer; Robert K. Hofstetter; Oliver Werz
作者单位Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, Jena, D-07743, Germany
Genetic variation in oxidative stress and detoxification pathways associated with prostate cancer susceptibility: a pathway-based analysis
作者Beatriz Álvarez-González; Carmen Maria Morales-Álvarez; Patricia Porras-Quesada; Lucia Chica-Redecillas; Marisa Cañadas-Garre; Antonio F. Hernández; María Jesús Álvarez-Cubero; Luis Javier Martínez-González
作者单位University of Granada, Legal Medicine and Toxicology Department, Faculty of Medicine, Health Sciences Technology Park (PTS), Granada, Spain; GENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Health Sciences Technology Park (PTS), Granada, Spain; University of Granada, Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, Health Sciences Technology Park (PTS), Granada, Spain; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Spain; Biosanitary Research Institute, ibs.GRANADA, Granada, Spain
Endothelial CD36 mediates Porphyromonas gingivalis-induced insulin resistance and vascular aging via mitochondrial dysfunction
作者Yuge Chen; Xuejia Zhang; Shengbin Huang; Maria Febbraio
作者单位Mike Petryk School of Dentistry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China
UCP1 maintains lipid homeostasis and developmental competence through MCU-mediated mitochondrial calcium uptake in bovine oocytes
作者Yuwen Luo; Jun Li; Yun Wang; Hejie Liu; Yizaitiguli Reyimjan; Qianyun Liang; Jie He; Jiachen Bai; Yuhan Wang; Xinhua Zou; Yaman Song; Yuanke Liu; Yidan Sun; Jiarui Luo; Haobo Hu; Yunpeng Hou; Xiangwei Fu
作者单位State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, 100193, China; College of Biological Sciences, China Agricultural University, Beijing, 100193, China; Department of Reproductive Medicine, Reproductive Medical Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050031, China; National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the MARA, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China; State Key Laboratory of Sheep Genetic Improvement and Healthy Breeding, Xinjiang Academy of Agricultural and Reclamation Sciences, Shihezi, Xinjiang, 832000, China
The iron overload caused by non-enzymatically glycated transferrin triggers oxidative stress and ferroptosis by regulating the PI3/AKT signalling pathway and the expression of Nrf2 to promote renal damage in diabetes
作者Pingping Zhao; Binjing Pan; Xiaoyu Lv; Lihua Ma; Jingfang Liu
作者单位The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China; Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
Mitocurcumin disrupts glutathione balance by modulating Klf9/GSR axis to overcome platinum resistance in non-small cell lung cancer and restores immune surveillance in cold tumor
作者Girish Ch. Panigrahi; Khushboo Gandhi; Amisha Joshi; Sheetal Dash; Shraddha Jadhav; Saurabh Kumar Gupta; Subhash Yadav; Sabita Jiwnani; Deepak Sharma; Santosh K. Sandur; Vikram Gota
作者单位Department of Clinical Pharmacology, Advanced Centre for Treatment, Research, and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India; Homi Bhabha National Institute (HBNI), BARC Training School Complex, Anushakti Nagar, Mumbai, Maharashtra, 400094, India; Clinician Scientist Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India; Department of Surgical Pathology, Advanced Centre for Treatment, Research, and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India; Department of Surgical Oncology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, 400012, India; Radiation Biology & Health Sciences Division, Bio-Science Group, Bhabha Atomic Research Centre, Trombay, Mumbai, Maharashtra, 400085, India
Macrophage-targeted Sod2 mRNA nanotherapy reduces mitochondrial oxidative stress and stabilizes vulnerable atherosclerotic plaques
作者Aleksandr E. Vendrov; Julia Levin; Jamille Silveira Fernandes Chamon; Andrey Lozhkin; Samuel A. Wickline; Hua Pan; Nageswara R. Madamanchi
作者单位Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO, 63110, USA
TBX15 increases ferroptosis to overcome sorafenib resistance via HERC5-mediated cGAS ISGylation in hepatocellular carcinoma
作者Hui Yuan; Mengfan Jiao; Ye Sun; Rui Liu; Xizhi Yin; Guizhong Zhou; Jianting He; Gen Zheng; Zihao Kong; Chuanlong Zhu
作者单位Department of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Wuhan, China; Department of Infectious and Tropical Diseases, The Second Affiliated Hospital of Hainan Medical University, Haikou, China; Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
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