医学
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ERK-dependent hyperexcitability of BLA neurons projecting to dCA3 underlies social dysfunction in a male mouse model of fragile X syndrome
作者Siyu Wang; Xiaotong Wu; Siyuan Dong; Lu Zheng; Libiao Pan; Li Zhan; Hanyang Xiao; Li Yang; Xiaomeng Wang; Huan Ma; Han Xu; Bingxing Pan; Lang Wang; Hao Wang
作者单位Department of Neurosurgery of Second Affiliated Hospital and School of Brain Science and Brain Medicine, Key Laboratory for Biomedical Engineering of Education Ministry, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Nanhu Brain-computer Interface Institute, Hangzhou, 311100, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Centre for Brain Research and Brain Machine Integration, Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Department of Gastroenterology, Ningbo Medical Centre LiHuiLi Hospital, Ningbo, Zhejiang, 315000, China; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330027, China; Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, 310027, China; Lingang Laboratory, Shanghai, 200031, China
Residential early-life air pollution exposure and oculomotor markers of cognitive workload in children: a prospective birth cohort study
作者Kenneth Vanbrabant; Eleni Renaers; Liesa Engelen; Brigitte Reimann; Hanne Croons; Thessa Van Pee; Maartje Vangeneugden; Nick Giesberts; Marcel Ameloot; Tim S. Nawrot; Michelle Plusquin
作者单位Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium; Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium; Department of Public Health and Primary Care, Environment and Health Unit, Leuven University, Leuven, Belgium
Gut microbiome profiling at multiple sclerosis onset as a potential early prognostic marker of disease course: evidence from an observational cohort study
作者Alessandro Maglione; Rachele Rosso; Dora Tortarolo; Francesco Pantini; Simone Pernice; Sandro Gepiro Contaldo; Roberta Lanzillo; Antonio Luca Spiezia; Cinzia Cordioli; Eleonora Virgilio; Federica Masuzzo; Manuela Matta; Simona Malucchi; Paola Cavalla; Luca Cocolin; Roberta Sirovich; Marco Beccuti; Ilario Ferrocino; Francesca Cordero; Marinella Clerico; Simona Rolla
作者单位Department of Clinical and Biological Sciences, University of Torino, Orbassano, Torino, 10043, Italy; Department of Computer Sciences, University of Torino, Torino, 10149, Italy; Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy; ASST Spedali Civili di Brescia, Multiple Sclerosis Centre, Montichiari, Italy; AOU San Luigi Gonzaga, SSD Specialist Neurological Pathologies, Orbassano, Italy; AOU San Luigi Gonzaga, CReSM, Orbassano, Italy; Department. of Neuroscience, University of Torino, MS centre, City of Health and Science University Hospital of Torino, Turin, Italy; Department of Agriculture, Forest and Food Science (DISAFA), University of Torino, Grugliasco, Torino, 10095, Italy; Department of Mathematics G. Peano, University of Torino, Torino, 10123, Italy
Discovering repurposable drugs for Alzheimer’s disease and related dementias: target trial emulation using decentralised real-world data
作者Qiong Wu; Lu Li; Yuqing Lei; Ting Zhou; Huilin Tang; Bingyu Zhang; Yiwen Lu; Maxwell Salvatore; Dazheng Zhang; Jiayi Tong; Tingyin Wang; Siqi Chen; Haoyang Li; Zhenxing Xu; Yu Huang; Yu Hu; Na Hong; Yujia Zhou; Fongci Lin; Kyra S. O’Brien; Yong Chen; Ruowang Li; Hua Xu; Fei Wang; Jiang Bian; David A. Wolk; Yong Chen
作者单位Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, PA, USA; The Center for Health AI and Synthesis of Evidence (CHASE), University of Pennsylvania, Philadelphia, PA, USA; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA; The Graduate Group in Applied Mathematics and Computational Science, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Penn Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Biostatistics and Health Data Science, Indiana University, Bloomington, IN, USA; Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, USA; Department of Biomedical Informatics and Data Science, School of Medicine, Yale University, New Haven, CT, USA; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Leonard Davis Institute for Health Economics, University of Pennsylvania, PA, USA; Real-World Evidence and Epidemiology, Chief Medical Office, Pfizer, Collegeville, PA, USA; College of Population Health, Thomas Jefferson University, Philadelphia, PA, USA; Department of Computational Biomedicine, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA; Penn Medicine Center for Evidence-based Practice (CEP), Philadelphia, PA, USA
Cepheid 9-gene host mRNA expression across the spectrum of Mycobacterium tuberculosis infection and disease: insights across the lifespan
作者Marva Seifert; Michael Gracia; Donald G. Catanzaro; Faiqa Rashid; Rehan R. Syed; Faisal Masood; Naomi Hillery; Alamdar Hussain; Ashley Swing; Rebecca E. Colman; Uzma Majeed; Antonino Catanzaro; Sabira Tahseen; Timothy C. Rodwell
作者单位Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, United States; Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, United States; Department of Biological Sciences, University of Arkansas, 601 Science Engineering Hall, Fayetteville, AR, 72701, United States; National Tuberculosis Control Program, National TB Reference Laboratory, CMU Offices, Block E and F, EPI Building, NIH Complex, Chak Shahzad, Islamabad, 44000, Pakistan; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, United States
A tablet-based attentional cognitive bias modification intervention for positive emotion processing in major depressive disorder: a single-blind randomised controlled two-centre trial
作者Zoe Katharina Kratochwil; Jessica Kesik; Duygu Keskin-Gökcelli; Katrin Sakreida; Norbert Scherbaum; Bernhard Wolfram Müller; Thomas Frodl
作者单位LVR-University Hospital Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, Virchowstraße 174, Essen, 45147, Germany; Department of Psychology, University of Wuppertal, Gaußstraße 20, Wuppertal, 42119, Germany; Hospital of Duisburg-Essen, Centre for Translational Neuro and Behavioural Sciences (C-TNBS), Medical Faculty University, Hufelandstraße 55, Essen, 45147, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany; German Centre for Mental Health (DZPG), partner site Halle-Jena-Magdeburg, Philosophenweg 3, Jena, 07742, Germany
Equity in genome sequencing for rare disease diagnosis: a cross-sectional analysis of data from the UK 100,000 Genomes Project
作者Sam Tallman; Loukas Moutsianas; Thuy Nguyen; Yoonsu Cho; Maxine Mackintosh; Dalia Kasperaviciute; Matthew A. Brown; Jamie M. Ellingford; Karoline Kuchenbaecker; Matt J. Silver
作者单位Genomics England, London, UK; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Alan Turing Institute, London, UK; Department of Medical and Molecular Genetics, King's College London, London, UK; Division of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Health Innovation Manchester, Manchester, UK; Division of Psychiatry, University College London, London, UK; Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Medical Research Council Unit the Gambia at the London School of Hygiene and Tropical Medicine, Serrekunda, the Gambia
Characterisation of a human monoclonal antibody targeting a conserved epitope at the base of the HA head of influenza A(H3N2) virus
作者Seiya Yamayoshi; Taiki Hamabata; Yuka Inoue; Maki Kiso; Moe Okuda; Hiroaki Akasaka; Wataru Shihoya; Takeaki Imamura; Yukimasa Matsuzawa; Daisuke Jubishi; Kiyoko Iwatsuki-Horimoto; Patrick C. Wilson; Osamu Nureki; Yoshihiro Kawaoka
作者单位Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan; The Research Center for Global Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center, Tokyo, Japan; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, NY, USA; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, WI, USA
Infradian rhythms of human heart rate reveal distinct multiday cycle periods in healthy adults
作者Rochelle I. De Silva; Rachel E. Stirling; Jodie Naim-Feil; Shivam Puri; Elizabeth Paratz; Philippa J. Karoly
作者单位Department of Biomedical Engineering, University of Melbourne, Melbourne, Australia; Graeme Clark Institute, University of Melbourne, Melbourne, Australia; Department of Medicine, St. Vincent’s Hospital Melbourne, University of Melbourne, Melbourne, Australia
Epigenetic ageing is accelerated in drug-resistant epilepsy and dynamically modulated during ketogenic diet therapy
作者Kristina Gervin; Magnhild Kverneland; Karl Otto Nakken; Knut Rudi; Per Ole Iversen; Kaja Kristine Selmer
作者单位Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway; Division of Clinical Neuroscience, National Centre for Epilepsy, Oslo University Hospital, Oslo, Norway; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway; Department of Haematology, Oslo University Hospital, Oslo, Norway; Department of Nutrition, University of Oslo, Oslo, Norway
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