医学
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Bacteroidesacidifaciens Attenuates Concanavalin A–Induced Liver Injury by Remodeling Bile Acids to Suppress CD95-Mediated Hepatocyte Apoptosis via the TGR5–FOSL1 Pathway
作者Xiang Zhang; Cheng Zhang; Yi Zhou; Yu Han; Yawei Wang; Hesuiyuan Wang; Mengyan Yang; Qinhan Wu; Feng Bai; Fanfan Qu; Jianbin Ji; Hongru Zhang; Zhenglu Wang; Yuebing Wang; Haijin Xu; Zhenghua Zhou; Mingqiang Qiao; Zhenzhou Wu
作者单位College of Life Sciences, Nankai University, Tianjin, China; Institute of Transplantation Medicine, Nankai University, Tianjin, China; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine, Tianjin, China; School of Medicine, Nankai University, Tianjin, China; Biological Sample Resource Sharing Center, Tianjin First Central Hospital, Tianjin, China; Tianjin Key Laboratory of Organ Transplantation, Tianjin First Central Hospital, Tianjin, China; Tianjin Organ Transplantation Research Center, Tianjin, China
Triggering Receptor Expressed on Myeloid Cells 2+ Macrophages Promote Pancreatic Regeneration Through Cholesterol–Metabolism Reprogramming and Hedgehog Signaling Activation Following Acute Pancreatitis
作者Pengli Song; Qi Peng; Xuerui Jin; Bin Li; Ruiyan Wang; Jing Jiang; Jie Shen; Jianbo Ni; Congying Chen; Xiaolu Ge; Xiao Han; Xingpeng Wang; Guoyong Hu
作者单位Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Ascites Bactericidal Capacity in Patients With Decompensated Cirrhosis
作者Isanka U. Ratnasekera; Min-Duy Phan; Nhu Nguyen; Eline E. Jessen; Sahar Keshvari; Yvette Ong; Timothy J. Kidd; Steven J. Hancock; Samuel A.S. Morris; David P. Sester; David A. Hume; Elizabeth E. Powell; Matthew J. Sweet; Mark A. Schembri; Katharine M. Irvine
作者单位Mater Research – The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia; Institute for Molecular Bioscience (IMB), The University of Queensland, St Lucia, Queensland, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia; Novoviah, Brisbane, Queensland, Australia; Centre for Liver Disease Research, The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia; QIMR-Berghofer Medical Research Institute, Herston, Queensland, Australia
Mucosal-Associated Invariant T Cells Drive Bile Duct Inflammation
作者Kathrine S. Nordhus; Fei Zheng; Natalie L. Berntsen; Oda Helgesen Ramberg; Laura Valestrand; Jonas Øgaard; Brian K. Chung; Xiaojun Jiang; Espen Melum
作者单位Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery and Specialized Medicine, Oslo University Hospital, Oslo, Norway; Research Institute of Internal Medicine, Division of Surgery and Specialized Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery and Specialized Medicine, Oslo University Hospital, Oslo, Norway; Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
Colon-Restricted Phosphatase and Tensin Homolog Deleted From Chromosome 10 Haploinsufficiency Models Phosphoinositide 3-Kinase Pathway-Driven Invasion in Colorectal Cancer
作者Haruki Sada; Hiroaki Niitsu; Yuji Urabe; Hikaru Nakahara; Masatoshi Kochi; Naoya Sakamoto; Yusuke Sotomaru; Hirotaka Tashiro; Shiro Oka; Hideki Ohdan; Eric R. Fearon; Takao Hinoi
作者单位Department of Surgery, NHO Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan; Department of Gastroenterological and Transplantation Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Higashihiroshima, Hiroshima, Japan; Department of Clinical and Molecular Genetics, Hiroshima University Hospital, Hiroshima, Japan; Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Higashihiroshima, Hiroshima, Japan; Department of Gastroenterological Surgery, NHO Higashihiroshima Medical Center, Higashihiroshima, Hiroshima, Japan; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East Japan, Kashiwa, Chiba, Japan; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan; Natural Science Center for Basic Research and Development, Hiroshima University, Higashihiroshima, Hiroshima, Japan; Department of Internal Medicine, Human Genetics, and Pathology, University of Michigan, Ann Arbor, Michigan
Gut Microbiota-Derived Propionate Governs Hepatic N2 Neutrophils in Wilson’s Disease
作者Xiaoxiao Mi; Rongqiang Liu; Zhenyao Jiang; Mengjuan Tang; Jian Yan; Jing Liu; Yingniang Li; Jun Zheng; Wenjun Yang; Ling Gong; Junping Shi
作者单位Institute of Translational Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China; Department of Infectious Diseases and Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China; School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China; School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Department of Pathology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China; Zhejiang Key Laboratory of Medical Epigenetics, Hangzhou, Zhejiang, China; Institute of Hepatology and Metabolic Diseases, Hangzhou Normal University, Hangzhou, Zhejiang, China
Helicobacter pylori-Induced Inflammatory Cancer Transformation Microenvironment Drives Gastric Carcinogenesis
作者Yufei Fu; Jiajing Tong; Manxuan Zhu; Liuyi Xu; Fengming Huang; Yixin Zhang; Xinyue Wang; Zhejiong Wang; Jingcheng Zhang; Jinjing Lv; Tao Jiang; Bin Lv; Guangji Zhang
作者单位Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang, China; Department of Gastroenterology, School of Pharmacy, Zhejiang University of Technology, Hangzhou, China; Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China
Disturbance of Oxylipin Metabolism Mediated by Autophagy of Mesenteric Adipocytes Orchestrates Gut Inflammation in Crohn’s Disease
作者Yi Yin; Xiaolong Zheng; Yufeng Wang; Siqing Jing; Shixian Wang; Yi Li; Meng Wang; Wei Ge
作者单位Division of Colorectal Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China; Division of Gastric Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China; Department of General Practice, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China; Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Protocadherin 20 Is a POU Class 2 Homeobox 3 Target Gene Required for Proper Tuft Cell Microvillus Organization
作者Katherine E. Ankenbauer; Yilin Yang; Chi-Yeh Chung; Leonardo R. Andrade; Sammy Weiser Novak; Brenda Jarvis; Wahida H. Ali Hanel; Jiayue Liu; Victoria Sarkisian; Neil Dani; Evan Krystofiak; Gaizun Hu; Seham Ebrahim; Bechara Kachar; Qizhi Gong; Geoffrey M. Wahl; Ken S. Lau; Jeffrey W. Brown; Uri Manor; Kathleen E. DelGiorno
作者单位Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California; Laboratory of Genetics and Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, California; Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, California; Biological and Physical Sciences Department, Columbus State Community College, Columbus, Ohio; Department of Molecular Physiology and Biological Physics, Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, Virginia; Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland; Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California; Chemical and Physical Biology Program, Vanderbilt University, Nashville, Tennessee; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, Tennessee; Division of Gastroenterology, Department of Medicine, Washington University in St. Louis, Missouri; Department of Cell and Developmental Biology, University of California, San Diego, California
Mast Cells Inhibit Stem Cell-driven Epithelial Repair in Inflammatory Bowel Disease via Suppressing Wnt/lrp6/β-Catenin Signaling Pathway
作者Tao Zhang; Jindong Zhang; Jingxian Xu; Xiaoang Li; Fei Pei; Liping Duan
作者单位Department of Gastroenterology, Peking University Third Hospital, Beijing, China; Beijing Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases, Beijing, China; Department of Pathology, Peking University Third Hospital, Peking University School of Basic Medical Sciences, Beijing, China
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