生物学
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10 篇有效样本 · 按发表日期由新到旧排列
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HDAC1 lactylation drives diabetic retinopathy by orchestrating a pro-angiogenic epigenetic program
作者Chunbo Zhang; Lin Liu; Yong Huang; Zibing Liao; Chuan He; Gaoshan Xu; Jiabing Zhu; Xiaopeng Yuan; Jin Su; Chao Gao; Yuanyuan Zhang; Benben Huang; Miao Cao; Weijian Zhu; Jin Liu; Liwen Zhao; Yipan Lai; Xiurong Gao; Linlin Liu; Xianfa Liu; Jinfang Zhang; Huiqiang Lu; Jianing Zhong
作者单位Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Basic Medical College, Gannan Medical University, Ganzhou 341000, China; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; Center for Genetic Development and Regenerative Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China; Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China; First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China; Jiangxi Province Key Laboratory of Drug Target Discovery and Validation, School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330006, China
GPX3 suppresses lung adenocarcinoma progression through HSPB1 ubiquitination and Hippo pathway activation
作者Sixuan Wu; He Huang; Junfan Pan; Yaqin Zheng; Qihong Pan; Sihui Chen; Jing Zhang; Yuehua Li; Yiquan Xu
作者单位Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China; Department of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China; Endoscopy Center, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China; Interdisciplinary Institute of Medical Engineering of Fuzhou University, Fuzhou 350108, China; Department of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China; NHC Key Laboratory of Cancer and Metabolism (Fujian Cancer Hospital), Fuzhou 350014, Fujian Province, China
A cross-species drug-discovery platform to accelerate the identification of lifespan-extending interventions
作者Kevin Perez; Lucas Schoenfeldt; Grace B. Phelps; Alberto Parras; Jonas Morin; Carla Pinto; Sebastien Guilmot; Tadeu Oliveira; Maria Silveira; Luca Dolfi; Alejandro Ocampo
作者单位EPITERNA, 1066 Épalinges, Switzerland; Institute of Oncology Research (IOR), 6500 Bellinzona, Switzerland; Università della Svizzera Italiana, 6900 Lugano, Switzerland; École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland; University of Lausanne, 1011 Lausanne, Switzerland
An Epstein-Barr virus-encoded snoRNA directs 2′-O-methylation of human rRNAs to control translation and the viral lytic switch
作者Yarden Dan; Beáta E. Jády; Yudit Halperin; Yuval Nevo; Aliza Fedorenko; Anat Bashan; Maram Arafat; Pnina Glick; Ada Yonath; Tamás Kiss; Daphna Nachmani
作者单位Department of Genetics, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; Molecular, Cellular, and Developmental Biology Department (MCD) UMR 5077, Centre de Biologie Intégrative (CBI), University of Toulouse, Centre National de la Recherche Scientifique, 31062 Toulouse, France; Info-CORE, Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem and Hadassah Medical Center, Jerusalem 91120, Israel; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel
Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state
作者Dominik Reichert; Sena Gul; Davide Ortolan; David McGaughey; Jair Montford; Jiwon Ryu; Alyssa S. Jeffrey; Colby F. Lewallen; Kati Veres; Rafael Villasmil; Noor D. White Carreiro; Stephen H. Tsang; Laryssa A. Huryn; Brian P. Brooks; Wadih Zein; Helen Louise May-Simera; Ruchi Sharma; Kapil Bharti
作者单位Ocular and Stem Cell Translational Research Section, National Eye Institute, NIH, Bethesda, MD 20892, USA; Ciliary Cell Biology, Institute of Molecular Physiology, Faculty of Biology, Johannes Gutenberg-University, Mainz, Germany; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, MD 20892, USA; Flow Cytometry Core, National Eye Institute, NIH, Bethesda, MD 20892, USA; Biological Imaging Core, National Eye Institute, NIH, Bethesda, MD 20892, USA; Departments of Ophthalmology, Pathology & Cell Biology, Columbia Stem Cell Initiative, New York, NY 10032, USA
Prohibitin controls MRS2-Mediated mitochondrial Mg2+ uptake to Shape bioenergetics
作者Soumya Maity; Manigandan Venkatesan; Adhishree Chidambaram; Sukanthathulse Uthayabalan; Louis Tung Faat Lai; Nicholas D. Clark; Abhinaya Lakkureddi; Karthik Ramachandran; Kristen Bentz; Ravi Ramalingam; Sanjana Sen; Moeez Akram; Susan T. Weintraub; Brij B. Singh; David Gius; Joseph A. Baur; Arianne L. Theiss; Jeffrey Caplan; Doreen Matthies; Peter B. Stathopulos; Muniswamy Madesh
作者单位Center for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada; Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA; Department of Periodontics, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Radiation Oncology, Mays Cancer Center MD Anderson, and the Joe R. and Teresa Lozano Long School of Medicine, University of Texas San Antonio Health Science Center, San Antonio, TX, USA; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19103, USA; Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado School of Medicine and Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO 80045, USA; Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA
Loss of laminin-γ1 in pericytes impairs microvascular function and cognition
作者Jingsong Ruan; Ava Nasrollahi; Cecilia Martin; Meisam Asgari; Andy Y. Shih; Yao Yao
作者单位Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, WA, USA; Department of Medical Engineering, University of South Florida, Tampa, FL, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA
16S ribosomal RNA modification drives transcript-specific translation efficiency
作者Zachory M. Park; Christina R. Savage; Amanda R. Decker-Farrell; Chin-Hsien Tai; Tapan K. Maity; Weiming Yang; Lisa M. Jenkins; Kumaran S. Ramamurthi
作者单位Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Type I interferon-activated myeloid states are associated with less fibrotic stages in idiopathic pulmonary fibrosis
作者Vishal Nathwani; Praveen Weeratunga; Jeongmin Woo; Laura Denney; Chaitanya Vuppusetty; Tian Hu; Sabrina Zulfikar; Andrew Achaiah; Leila Baghaarabani; Harriet Parker; Huei-Wen Chuang; Michalina Mazurczyk; Aleksandr Fedorov; Alison Simmons; Colin Clelland; Jan Rehwinkel; Agne Antanaviciute; Ling-Pei Ho
作者单位MRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, OX3 7LJ Oxford, UK; MRC WIMM Imaging Facility, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, UK; Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, OX3 9DS Oxford, UK
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