医学
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Defined human Clostridia consortia reverse colitis via dual effects of tryptophan metabolites on microbiota and immunity
作者Akihiko Oka; Gerold Bongers; Yoshiyuki Mishima; Andrew J. Baltus; Simon M. Gray; Bo Liu; Jeremy W. Herzog; John R. Benedetto; Ting-Jia Fan; Jisun Jang; Muyiwa Awoniyi; Esmat Rousta; Ling-Yang Hao; Raad Z. Gharaibeh; Anthony A. Fodor; Toshifumi Ohkusa; Koji Atarashi; Shinji Fukuda; Kenya Honda; Lani R. San Mateo; R. Balfour Sartor
作者单位Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan; Johnson & Johnson, Spring House, PA 19477, USA; The National Gnotobiotic Rodent Resource Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Internal Medicine, Veterans Health Service Medical Center, Seoul 05368, Korea; Digestive Disease Institute, Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Medicine, Division of Gastroenterology, University of Florida, Gainesville, FL 32608, USA; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32608, USA; Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC 28223, USA; Department of Microbiota Research, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Microbiology and Immunology, Human Biology Microbiome Quantum Research Center (WPI-Bio2Q), Keio University, Shinjuku-ku, Tokyo, 160-8582, Japan; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan; Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, Kanagawa 210-0821, Japan; Transborder Medical Research Center, University of Tsukuba, Ibaraki 305-8575, Japan; Innovative Microbiome Therapy Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containment
作者Erika J. Hughes; Charlie J. Pyle; Mark Chambers; Jana Travnickova; Thabo Mpotje; Jacob P. Lowy; Nathan T. Strang; Carson E. Carranza; Henry K.E. Ohman; Threnesan Naidoo; Liuyang Wang; Dennis C. Ko; Jadee L. Neff; Simon G. Gregory; Clare M. Smith; Jason E. Stout; Fred B. Lih; Matthew L. Edin; Darryl C. Zeldin; E. Elizabeth Patton; Mohlopheni J. Marakalala; Alasdair Leslie; David M. Tobin
作者单位Department of Molecular Genetics and Microbiology, Duke School of Medicine, Durham, NC 27710, USA; University Program in Genetics and Genomics, Duke School of Medicine, Durham, NC 27710, USA; Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA; Africa Health Research Institute, Durban, KwaZulu-Natal, South Africa; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK; SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; School of Pathology, Faculty of Medicine & Health Sciences, Walter Sisulu University, Mthatha, Eastern Cape, South Africa; Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USA; Mass Spectrometry Research Center National Institute of Environmental Health Sciences, Durham, NC 27709, USA; Clinical and Translational Research Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA; Department of Infection and Immunity, University College London, London, UK
Bacterial endosymbionts enhance fungal virulence by disrupting the disease-suppressive rhizobiome
作者Xingang Zhou; Xianhong Zhang; Lingyi Ran; Dongli Liu; Huiting Jia; Jingyu Zhang; Nan Zhang; Muhammad Khashi u Rahman; Alexandre Jousset; Francisco Dini-Andreote; Fengzhi Wu; Zhong Wei
作者单位Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (Northeast Region, Ministry of Agriculture and Rural Affairs), Heilongjiang Key Laboratory of Cold Area Protected Horticulture, Department of Horticulture, Northeast Agricultural University, Harbin, China; Department of Microbiology and Genetics and Institute for Agribiotechnology Research (CIALE), University of Salamanca, Salamanca, Spain; Jiangsu Provincial Key Lab for Solid Organic Waste Utilization, Key Lab of Organic-based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-saving Fertilizers, Nanjing Agricultural University, Nanjing, China; Department of Plant Science and Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA; The One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA
Mouth-to-gut microbial transmission signatures enable robust, non-invasive diagnosis of gastrointestinal cancers
作者Lae-Guen Jang; Ji-Won Huh; Seolah Kim; Ji-Young Lee; Hee-Soo Hwang; Jaekyung Yoon; Hyeon Gwon Lee; Tae Il Kim; Yong Chan Lee; Sun Ha Jee; Jihyun F. Kim
作者单位Department of Systems Biology, Division of Life Sciences, Institute for Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea; Department of Convergent Bioscience and Informatics, College of Bioscience & Biotechnology, Chungnam National University, Daejeon, Republic of Korea; Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Transdisciplinary Healthcare Sciences, Graduate School of Transdisciplinary Health Science, Yonsei University, Seoul, Republic of Korea; Microbiome Initiative, Yonsei University, Seoul, Republic of Korea
Strong, sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility
作者Stefan A. Fattinger; Bianca Parisi; Roberto A. Chavez; Marian R. Fairgrieve; Ophelia V. Lee; Kristen C. Witt; Jesse J. Rodriguez; Elizabeth A. Turcotte; Ella C. Brydon; Harmandeep Dhaliwal; Angus Y. Lee; Dmitri I. Kotov; Russell E. Vance
作者单位Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA, USA; Center for Emerging and Neglected Diseases, University of California, Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA
Cell-type-specific activation of broadly perceived effector-triggered immunity restricts pathogen invasion in plants
作者Himanshu Chhillar; Leonardo Jo; Volkan Cevik; Amey Redkar; Kaisa Kajala; Jonathan D.G. Jones; Pingtao Ding (丁平涛)
作者单位Institute of Biology Leiden, Leiden University, Leiden, 2333 BE, the Netherlands; Laboratory of Molecular Biology, Wageningen University & Research, Wageningen, 6708 PB, the Netherlands; Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK; The Sainsbury Laboratory, University of East Anglia, Norwich, NR4 7UH, UK; Experimental & Computational Plant Development, Institute of Environmental Biology, Utrecht University, Utrecht, 3584 CS, the Netherlands
Lactobacillus gasseri postbiotics ameliorate age-related decline in endometrial receptivity
作者Meng Li; Shangqi Li; Danlei Zheng; Baoying Liao; Hongjuan Niu; Yue Wang; Xiyao Liu; Heng Pan; Yang Yu; Ping Zhou; Rong Li
作者单位State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China; Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing, China; Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China; National Clinical Key Specialty Construction Program, Beijing, China; Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing, China
Unveiling active microbial processes in Earth’s deepest seawater
作者Wei-Jia Zhang; Aoran Hu; Ziheng Wu; Liangting Liu; Chen Li; Yujue Wang; Zhanfei Wei; Rui Lu; Jun Li; Yang He; Taoliang Zhang; Shanshan Liu; Jing Wang; Liang Meng; Xiang Xiao; Weishu Zhao
作者单位Institute of Deep-Sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China; International Center for Deep Life Investigation (IC-DLI), Hainan Research Institute, Shanghai Jiao Tong University, Sanya 572025, China; Institution of Deep Life and Resource Investigation (IDLRI), State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Center for High Performance Computing, Shanghai Jiao Tong University, Shanghai 200240, China; Shanghai Changxing Ocean Laboratory, Shanghai Jiao Tong University, Shanghai 201913, China; BGI Research, Sanya 572025, China; BGI, Shenzhen 518083, China; Institution of Deep-sea Life Sciences, IDSSE-BGI, Hainan Deep-sea Technology Laboratory, Sanya 572000, China; Hainan Technology Innovation Center for Marine Biological Resources Utilization (Preparatory Period), BGI Research, Sanya 572025, China; Shanghai Academy of Natural Sciences (SANS), Shanghai 200000, China
Engineering oral commensal nanovaccines to activate mucosal-systemic immune cascades against tumor
作者Zirong Dong; Shuyan Li; Yuning Wei; Jiaxin Zhao; Weiwen Kong; Wenjuan Liu; Jian Chen; Haisheng He; Jinlong Yang; Jianping Qi
作者单位School of Pharmaceutical Sciences, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai 201203, China
RNA quality control enables antibiotic tolerance
作者Andrew T. Nishimoto; Juan C. Ortiz-Marquez; Michelle R. Scribner; Yanying Yu; Qidong Jia; Haley Echlin; Amy R. Iverson; Abigail E. McKnight; Nadia Olivero; Aaron Poole; Enolia Marr; Jordan Coggins; Adam Rosenthal; Chrispin Chaguza; Randolph K. Larsen; Mark E. Hatley; Ralph R. Isberg; Vaughn S. Cooper; Tim van Opijnen; Jason W. Rosch
作者单位Department of Host-Microbe Interactions, St. Jude Children’s Research Hospital, Memphis, TN, USA; Department of Medical Education, University of Tennessee College of Medicine, Memphis, TN, USA; Boston Children’s Hospital, Division of Infectious Diseases, Harvard Medical School, Boston, MA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA; Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Microbiology and Immunology, UNC School of Medicine, Memphis, TN, USA; Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA
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