生物学
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An ER stress-responsive RNA rheostat for programmable gene and mRNA therapies
作者Roza Ogurlu; Eliya B. Sanchez; Joshua A. Hull; Sophia M. Fergione; Vivian Yudistyra; Gabriela M. Webb; Helen L. Wu; Cleiton T. Pessoa; Matthew C. Humkey; Sofia K. Potter; Alan Rosales; Heather A. Vincent; Jonah B. Sacha; Aravind Asokan
作者单位Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Surgery, Duke University School of Medicine, Durham, NC 27708, USA; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97239, USA; Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC 27708, USA
The BAX/BAK apoptotic checkpoint polices entry to therapy-induced senescence
作者Aislinn Gallagher Aldave; Vaishnavi Venugopalan; Gokhan Gunay; Seren Hamsici; Ronaldo Rodrigues Ribeiro; Aoife Costigan; Anna Gabrielyan; Hande Efe-Cicek; Seamus J. Martin
作者单位Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin, Ireland
A protective human antibody reveals a quaternary epitope on the Epstein-Barr virus fusion apparatus
作者Ge-Xin Zhao; Xin-Yan Fang; Ting Li; Guo-Long Bu; Jing Wang; Wen-Ting Du; Pei-Huang Wu; Hang Zhou; Guo-Kai Feng; Sen-Fang Sui; Cong Sun; Zheng Liu; Mu-Sheng Zeng
作者单位State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Cryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, Guangdong, China; Department of Pharmacology, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China; Department of Dermatology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA
Aptamer targeting HMGB1 attenuates inflammatory disease via domain-specific antagonism
作者Hui Zhang; Lele Ma; Shaoju Gan; Mengyuan Jiang; Zheng Zhang; Weidi Sun; Wanlin Xie; Peiyu Xi; Fengli Qu; Weihong Tan
作者单位School of Chemistry and Materials, University of Science and Technology of China, Hefei, Anhui 230026, China; School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, P.R. China
RNA-dependent SFPQ condensates coordinate multidimensional regulation of extra-long neuronal genes
作者Motoyasu Hosokawa; Ryosuke Kawakami; Koshi Imami; Ryo Kurosawa; Takuya Yoshizawa; Yasushi Ishihama; Takeshi Imamura; Masatoshi Hagiwara; Akihide Takeuchi
作者单位Department of Developmental Biology and Functional Genomics, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon City, Ehime 791-0295, Japan; Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon City, Ehime 791-0295, Japan; Proteome Homeostasis Research Unit, RIKEN Center for Integrative Medical Sciences (RIKEN IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan; Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; Department of Biotechnology, College of Life Sciences, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Japan; Laboratory of Molecular Systems BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
XPO1 inhibition induces NCOR1-Dependent oxidative stress to suppress hepatocellular carcinoma
作者Wei Wang; Linmeng Zhang; Qiaozhu Zuo; Xuhui Ma; Ying Cao; Lili Zhu; Shuyi Ji; Wenxin Qin; Hui Wang; Shengxian Yuan; René Bernards; Cun Wang
作者单位State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute & Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Liver Surgery and Transplantation, Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands
Small-molecule inhibitors of the protein kinase DYRK as potential therapeutic candidates in cancer
作者Prabhadevi Venkataramani; Elad Elkayam; Ankur Garg; Kai Fan Cheng; Ahmad Altiti; Mingzhu He; Khushabu Thakur; Evdokia Michalopoulou; Camila Gonzalez; Christy Felice; Linda Van Aelst; Darryl Pappin; Leemor Joshua-Tor; Yousef Al-Abed; Nicholas K. Tonks
作者单位Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA; Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA; Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity
作者Qingqing Hao; Laurie Wang; Hui Pan; Xihui Xiao; Wenyan Dong; Wencong Pan; Jingjing Sun; Wu Su; Lijing Fang; Eunyong Park; Guiyang Yao
作者单位School of Life Sciences, Fudan University, Shanghai 200438, China; Greater Bay Area Institute of Precision Medicine (Guangzhou), Guangzhou 510000, China; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China; University of Chinese Academy of Sciences, Beijing 100049, China
Chemical modulation of Miro1 alleviates cell-type-specific vulnerabilities in Friedreich's ataxia
作者Sujyoti Chandra; Chulhwan S. Kwak; Zehui Du; Giuseppe Barisano; Kong T. Nguyen; Vlad Vinogradov; Xinnan Wang
作者单位Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Optic, Inc., San Francisco, CA 94105, USA
Optogenetic control of plasma membrane O-GlcNAcylation regulates WNK1 condensates and cellular signaling
作者Qiang Zhu; Qianyu Liu; Zhiya Fan; Yixiang Shi; Xinliang Liu; Yibo Guo; Jiancheng Luo; Jingguo Zhao; Weijie Qin; Yong Wang; Ping Wang; Haifeng Ye; Wen Yi
作者单位Departments of Biochemistry & Biophysics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China; State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China; Center for Chemical Glycobiology, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, National Key Laboratory of Innovative Immunotherapy, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Synthetic Biology and Biomedical Engineering Laboratory, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
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