医学
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CAR T Cells Targeting O-Glycosylated Fibronectin Exhibit Potent Cytolytic Activity and Combine with Tumoral Toll-Like Receptor Agonism to Overcome Tumor Resistance
作者Tiffany R. King-Peoples; John T. Keane; Hyeon-Gyu S. Lewis; Fang Liu; Shawna K. Brookens; Oula K. Dagher; Kalpana Parvathaneni; Brittany L. Gardner; Amal Ahmed; Emma E. Furth; Priti Lal; Avery D. Posey
作者单位1. University of Pennsylvania 1 Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, , Philadelphia, Pennsylvania.; 2. University of Pennsylvania 2 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, , Philadelphia, Pennsylvania.; 3. 3Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania.
In Situ Vaccination, Low-Dose Targeted Radionuclide Therapy, and Immune Checkpoint Inhibition Eradicate Poorly Immunogenic Metastatic Tumors in Murine Cancer Models
作者Trishna Debnath; Won Jong Jin; Ravi B. Patel; Peter M. Carlson; Md Mahfuzur Rahman; Tracy J. Berg; Caroline P. Kerr; Rene Welch Schwartz; Yujuan Wang; Meredith Hyun; Irene M. Ong; Jamey P. Weichert; Reinier Hernandez; Paul M. Sondel; Zachary S. Morris
作者单位1. 1Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.; 2. 2Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.; 3. Emory University 3 Department of Pediatrics, , Atlanta, Georgia.; 4. 4Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.; 5. 5Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.; 6. 6Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.; 7. 7Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
VISTA+ Neutrophils Contribute to Platinum Resistance by Suppressing CD8+ T Cells in High-Grade Serous Ovarian Cancer
作者Chuying Huo; Xibo Zhao; Dongdong Ye; Shaodan Lin; Dongdong Xu; Suen Wai Pang; Miaochun Xu; Junting Chen; Chunxian Huang; Yunyun Liu; Aoshuang Cheng; Lingjie Yang; Zhongqiu Lin; Lijuan Wang; Bowen Li; Huaiwu Lu
作者单位1. Sun Yat-sen Memorial Hospital 1 Department of Gynecologic Oncology, , Sun Yat-sen University, Guangzhou, China.; 2. Sun Yat-sen Memorial Hospital 2 Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, , Sun Yat-sen University, Guangzhou, China.; 3. Sun Yat-sen Memorial Hospital 3 Department of Radiology, , Sun Yat-sen University, Guangzhou, China.; 4. Sun Yat-sen Memorial Hospital 4 Department of Oral and Maxillofacial Surgery, , Sun Yat-sen University, Guangzhou, China.
Enhancement of Ferroptosis in Escape Variant Tumor Cells by IFNγ Derived from Antigen-Specific T Cells Controls Tumor with Heterogeneity
作者Daisuke Ehara; Kiyoshi Yasui; Mitsuhiro Yoneda; Daisuke Muraoka; Situo Deng; Pengyu Miao; Chenxu Jiang; Huimin Sun; Sachiko Okamoto; Yasunori Amaishi; Hiroyuki Murota; Hiroaki Ikeda
作者单位1. 1Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; 2. 2Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; 3. 3Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan.; 4. 4Takara Bio Inc., Kusatsu, Japan.; 5. 5Leading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Coordinated Immune Activation Following KRAS Inhibition in Syngeneic Models Reveals Molecular Pathways that Potentiate and Limit Antitumor Immunity
作者Daniel R. Lu; Tao Osgood; Shining Ma; Huajia Zhang; Matt Kanke; Jessica A. Tan; Siddhi N. Paudel; Hong Zhou; Juan Estrada; Tracy Yamawaki; Kristin Tarbell; Karen Rex; Jason DeVoss; Scott Martin; Songli Wang; Jude Canon; J. Russell Lipford; Angela Coxon; Chi-Ming Li
作者单位1. 1Target Discovery & Biology of DATA, Amgen Global Research, South San Francisco, California.; 2. 2Oncology Research, Amgen Global Research, Thousand Oaks, California.; 3. 3ARIA of DATA, Amgen Global Research, South San Francisco, California.; 4. Amgen Global Research 4 Oncology Research, , South San Francisco, California.
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