医学
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FAP-targeted gold nanocluster-mediated radioligand therapy in combination with TGF-βRI inhibition for tumor therapy
作者Huizhen Yang; Liu Liu; Guoping Jia; He Gao; Wangxi Hai; Qinghe Wu; Jia Xu; Yifei Jiang; Chunfu Zhang
作者单位Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China; Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; Department of Nuclear Medicine & Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; China National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, China
Micro/nanoscale bubble-mediated mucolytic conditioning of the lung model of cystic fibrosis enhances nanoparticle transport through the mucus
作者Mohamed Diane; Maria R. Hudock; Julie Leonard-Duke; Arvind Nandakumar; Ylleana Goduco; Mohammad Mir; Aneri Patel; Jiawen Chen; Veronica Farag; Meghan R. Pinezich; Julie Van Hassel; Alexander Yoon; Rahul Kanade; Panpan Chen; Alexander Romanov; Jinho Kim; Gordana Vunjak-Novakovic
作者单位Department of Biomedical Engineering, Columbia University, New York, NY, USA; Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA; Department of Medicine, Columbia University, New York, NY, USA; Institute of Comparative Medicine, Columbia University Medical Center, New York, NY, USA
Triple gene-knockout xenogeneic bone repair material achieves synergistic optimization of bone repair immunomicroenvironment and bone regeneration via antigen-immunity-inflammation axis modulation
作者Yuanhang Han; Yifan Hu; Yushen Lu; Ruimin Wang; Yuyang Wang; Zhenyi Chen; Zhiqiang Yang; Xiaoxiao Liang; Jie Yan; Yuanlong Xie
作者单位Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan City, Hubei Province, 430071, PR China; The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou City, Henan Province, 450008, PR China; Xenotransplantation and Regeneration Key Laboratory of Sichuan Province, Chengdu ClonOrgan Biotechnology Co., Ltd., Chengdu City, Sichuan Province, 610095, PR China
A mitochondrial inflammation-oriented nanozyme coordinates dual inflammatory axes to restore alveolar bone homeostasis in periodontitis
作者Tiancheng Li; Cheng Zhu; Yixin Li; Qicheng Liu; Runzhe Fang; Zitong Yang; Luyao Qu; Xinyue Tang; Yu Jin; Bing Fang; Lunguo Xia
作者单位Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, 200011, China; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, China
Bioactive vitamin E-NAD+ conjugate nanoparticles for osteoarthritis management via simultaneous suppression of inflammation and oxidative stress
作者Wanying Zhai; Xinyang Mao; Aixian Tian; Jing Jia; Zukang Miao; Aidong Liu; Ning Zhao; Zheng Wang; Xiujie Zhao; Xin Li; Xinlong Ma; Yanjun Zhao
作者单位Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, School of Pharmaceutical Science & Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China; Department of Orthopedics, Tianjin Hospital, Tianjin University, Tianjin, China
Transforming adoptive macrophages into living immune amplifiers with intracellular nanobatteries to potentiate tumor immunotherapy
作者Haijing Qu; Yuqing Pan; Qingping Wu; Jie Wu; Han Chen; Ning Wang; Wei Meng; Zejian Wang; Xiangdong Xue
作者单位Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, National Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China
Hybrid bacteriophage hydrogels deplete intratumoral bacteria to potentiate oncolytic immunotherapy
作者Bai Lv; Xichao Zhang; Tingting Liu; Weijie Wang; Ling Xu; Shenjie Zhong; Feng Jin; Yuehua Xu; Jie Cao; Gang Chen
作者单位Shandong Provincial Key Medical and Health Laboratory of Neuro-oncology of Innovative Integrated Medicine, Qingdao Central Hospital, School of Life Sciences and Health, University of Health and Rehabilitation Sciences, Qingdao, 266042, China; Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, 266071, China; Department of Clinical Laboratory, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, 266042, China; Department of Orthopedics, Affiliated Hospital of Yangzhou University, Yangzhou, 225009, China; Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China
An intelligent phototheranostic nanoplatform for controllable FRET-activated NIR-II imaging-guided phototherapy
作者Anan Wang; Zhiwei Tao; Suwen Chen; Rumeng Zhan; Wenlong Huang; Wenchen Wang; Jingyan Zhang; Hongyu Ma; Weian Zhang; Jia Tian
作者单位Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China
A self-initiating battery-like hydrogel for autonomous pH normalization and immune activation in postoperative tumor therapy
作者Wenyan She; Xinyi Ding; Qianran Cao; Yaqian Song; Chenxi Huang; Lin Hou
作者单位School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Henan Key Laboratory of Nanomedicine for Targeting Diagnosis and Treatment, Zhengzhou University, Zhengzhou, 450001, China; State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, Zhengzhou University, Zhengzhou, 450001, China
UV-programmed gelatin methacryloyl hydrogel microenvironments reveal a bell-shaped vascularization window and enable compartmentalized neuromuscular disease modeling
作者Chun-Chuan Ni; Chun-Sheng Yu; Shih-Yen Wei; Jun-Zhi Dai; Chih-Ling Chang; Hsiao-Chien Ting; Chia-Yu Chang; Ying-Chieh Chen
作者单位Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan; Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, 02115, USA; Bioinnovation Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Neuroscience Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Center for General Education, Tzu Chi University, Hualien, Taiwan; College of Semiconductor Research, National Tsing Hua University, Hsinchu, Taiwan; College of Sustainability, National Tsing Hua University, Hsinchu, Taiwan
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