医学
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A logic-gated nanoplatform spatiotemporally orchestrates immunometabolic reprogramming and osteogenesis for diabetic periodontal regeneration
作者Yujun Jiang; Shuyun Liu; Xiaolin Li; Lu Han; Hongrui Liu; Minqi Li
作者单位Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Diseases & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, China; Department of Orthodontics, Qilu Hospital of Shandong University, Jinan, 250012, China; Center of Osteoporosis and Bone Mineral Research, Shandong University, China; Key Laboratory of Marine Drugs, Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotherapeutics, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, 266237, China; Department of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, China
Barcoded oligonucleotide system (BOLT) for targeted organ delivery
作者Xucheng Hou; Changyue Yu; Yonger Xue; Yuwei Liu; Diana D. Kang; Jeffrey L. Bennett; Eliza Bliss-Moreau; Mi Ni; Yujie Liu; Gang Fang; Ya Ying Zheng; Siyu Wang; Meng Tian; Yichen Zhong; Haoyuan Li; Zhengwei Liu; Dinglingge Cao; Yizhou Dong
作者单位Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA; California National Primate Research Center, University of California Davis, Davis, CA, 95616, USA; Department of Psychology, University of California Davis, Davis, CA, 95616, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
A multifunctional MOF-mineralized conductive hydrogel coating on zinc implants orchestrates neuro-osteogenic coupling for enhanced bone defect repair
作者Yujia Wei; Dong Mo; Meng Pan; Tingyu Yang; Xicheng Li; Lin Ye; Jianan Li; Liping Yuan; Zhongwu Bei; Zhiyong Qian
作者单位Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Radiology, Chongqing Academy of Medical Sciences, Chongqing General Hospital Chongging University , Chongging, China; Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Chongqing Institute for Food and Drug Control, Chongqing, 401121, China
Water-responsive injectable hydrogel achieving rapid in situ gelation and long-term colonic mucoadhesion for efficient fecal microbiota transplantation
作者Zixin Chen; Yang Li; Wenxuan Xiong; Pengwei Ma; Weijie Liu; Hui Zhou; Xinglong Wang; Youchen Tang; Jian Cai; Mingli Su
作者单位Department of General Surgery (Colorectal Surgery), Guangdong Institute of Gastroenterology, Biomedical Innovation Center, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, PR China; The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, PR China; PCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, PR China; Department of Colorectal Surgery, The First Affiliated Hospital, Shenzhen University, Shenzhen Second People's Hospital, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, 518035, PR China; Department of General Surgery (Endoscopic Surgery), Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, Key Laboratory of Human Microbiome and Chronic Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, PR China
Hierarchical Nanorocket for spatially coordinated regulation of glycosaminoglycan deposition and metabolism in cartilage
作者Hang Su; Qiuwen Zhu; Junle Xiang; Qinyuan Wu; Wei Sun; Jinghua Fang; Wenyue Li; Chang Xie; Rui Li; Yishan Chen; Xiaohui Zou; Hongwei Ouyang
作者单位Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang University-University of Edinburgh Institute, Haining, 314400, China; Central Laboratory, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China
Ultrasound-activated piezoelectric muscle constructs for tissue-engineered regenerative peripheral nerve interfaces
作者Lorenzo Vannozzi; Juliana Redondo; Diego Trucco; Carlotta Pucci; Leonardo Boccoli; Camilla Schirru; Marta Gherardini; Waleed Mustafa Ali Al-ghilan; Paola Parlanti; Mauro Gemmi; Paolo Sassu; Emanuele Gruppioni; Christian Cipriani; Leonardo Ricotti
作者单位The BioRobotics Institute, Scuola Superiore Sant’Anna, Pisa, 56127, Italy; Department of Excellence in Robotics & AI, Scuola Superiore Sant’Anna, Pisa, 56127, Italy; Center for Materials Interfaces, Electron Cristallography, Istituto Italiano di Tecnologia, Pontedera, 56025, Italy; Clinica IV - Ortoplastica, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy; Centro Protesi INAIL, Istituto Nazionale per l’Assicurazione contro gli Infortuni sul Lavoro, Vigorso di Budrio, 40054, Italy
Bioprinted core-shell living material platform for spatially controlled encapsulation of Bacillus subtilis and sustained metabolite exchange
作者Lin Huang; Kathleen L. Furtado; William Brakewood; Maxwell Neal; Yazhi Sun; Jasmine Le; Qi Xie; Jacob Hizon; Shivam Singhal; Mariana Salas Garcia; Joshua Tran; Karsten Zengler; Michael Betenbaugh; Jack A. Gilbert; Shaochen Chen
作者单位Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, USA; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Bioengineering, University of California San Diego, La Jolla, USA; Department of Chemistry, Johns Hopkins University, Baltimore, MD, USA; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA
Bioactive glasses-mediated ion therapy ameliorates hepatic osteodystrophy by reprogramming the liver-bone axis
作者Shuang-Chi Liu; En Xie; Peng Zhao; Yu-Shi Liu; Zi-Ying Xie; Hao-Dang Chang; Wei-Dong Zhao; Peng-Yu Huang; Yun-Xia Zhu; Muhammad Atiq Ur Rehman; Yunxi Gao; Luca Urbani; Li-Ming Gou; Juan Ye; Yuan Gao; Xi-Hu Qin; Kai Zheng; Jing Wu; Bin Xue
作者单位Translational Medicine Research Center and Jiangsu Key Laboratory of pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, 211166, China; Department of General Surgery, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, 213003, China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine&State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Nanjing, 211166, China; Department of General Surgery, The Affiliated Taizhou people's Hospital of Nanjing Medical University, Taizhou, Jiangsu, 225300, China; Department of Developmental Cell Biology, China Medical University, 77 Puhe Road, Shenbei New District, Shenyang, 110122, China; State Key Laboratory of Advanced Medical Materials and Devices, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, 300000, China; Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 211166, China; Department of Materials Science and Engineering, Institute of Space Technology, Islamabad, 44000, Pakistan; Roger Williams Institute of Liver Studies, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research, King's College Hospital, London, SE5 9RS, UK; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 211166, China; NHC Key Laboratory of Antibody Technique, Nanjing Medical University, Nanjing, China; Jiangsu Province Engineering Research Center of Antibody Drug, Nanjing, 211166, China; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China
Dual metabolic checkpoint blockade via a 3D-Printed metalloplatform remodels the tumor ecosystem for systemic antitumor immunity
作者Xiaoyan Meng; Zhonglong Liu; Yongqiang Hao; Yingchun Zhu; Jianfeng Gu; Haozhang Zhong; Yue He; Jingke Fu
作者单位Department of Oral Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China; Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine, Shanghai, 200011, China; Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China; Institute of Materials Modification and Modeling, Shanghai Jiao Tong University, Shanghai, 200240, China
Quercetin-derived carbon dots-modified ZIF-8 and M2 macrophage-derived migrasomes-functionalized microenvironment-responsive nanocomposite hydrogel for osteoporotic bone defects regeneration
作者Han Yin; Yuguo Li; Yanbin Zhu; Zineng Yan; Yuanyuan Han; Fangyan Cheng; Jinglue Hu; Jiangtao Ma; Xin Xing; Cao Yang; Hongtao Tian; Wei Chen; Yingze Zhang
作者单位Department of Orthopaedics Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China; Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, 050051, China; Department of Orthopaedics Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China; Department of Plastic and Burn Surgery, National Key Clinical Construction Specialty, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646099, China
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