医学
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The Impact of Enrollment Strategies on the Performance of Time‐To‐Event Dose‐Escalation Designs for Phase I Drug Combination Oncology Trials
作者Xiaowen Tian; Michael Sweeting; Kristine Broglio
作者单位1. Oncology Biometrics, Oncology R&D AstraZeneca Gaithersburg Maryland USA; 2. Oncology Biometrics, Oncology R&D AstraZeneca Cambridge UK
Applying the Promising Zone Method to Biomarker‐Based Adaptive Designs: A Word of Caution
作者Jingzhao Wang; Ruobing Li; Jun Zhao; Zhimin Tang; Jianhong Pan
作者单位1. Office of Biostatistics and Clinical Pharmacology, Center for Drug Evaluation National Medical Products Administration Beijing China
Degrees‐of‐Freedom Approximations for Conditional‐Mean Inference in Random‐Lot Stability Analysis
作者Andrew T. Karl; Heath Rushing; Richard K. Burdick; Jeff Hofer
作者单位1. Karl Statistical Services LLC Aurora Colorado USA; 2. Adsurgo LLC San Antonio Texas USA; 3. Burdick Statistical Consulting, LLC Colorado Springs Colorado USA; 4. JDH CMC Stats, LLC Avon Indiana USA
Dose Optimization Design for Randomized Phase II Trials With Toxicity and Efficacy Endpoints
作者Ryuta Tabata; Tomohiro Ohigashi; Takashi Sozu
作者单位1. Department of Information and Computer Technology, Graduate School of Engineering Tokyo University of Science Tokyo Japan; 2. Department of Information and Computer Technology, Faculty of Engineering Tokyo University of Science Tokyo Japan
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