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Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours
作者Iris D Nagtegaal; Elizabeth A Montgomery; Alexandros D Polydorides; Anthony J Gill; Motohiro Kojima; Mark J Arends
作者单位1. Department of Pathology Radboudumc Nijmegen The Netherlands; 2. Department of Pathology University of Miami Miller School of Medicine Miami FL USA; 3. Department of Pathology, Molecular, and Cell‐Based Medicine Icahn School of Medicine at Mount Sinai New York NY USA; 4. NSW Health Pathology, Department of Anatomical Pathology Royal North Shore Hospital St Leonards NSW Australia; 5. Sydney Medical School University of Sydney Sydney NSW Australia; 6. Department of Surgical Pathology Kyoto Prefectural University of Medicine Graduate School of Medical Science Kyoto Japan; 7. Edinburgh Pathology, Institute of Genetics & Cancer University of Edinburgh Edinburgh UK
Tumor Invasive Border Index ( TIBI ) in colorectal cancer: linking infiltrative morphology to molecular insights
作者Akseli Kehusmaa; Jouni Härkönen; Huayi Li; Päivi Sirniö; Ville K Äijälä; Henna Karjalainen; Meeri Kastinen; Vilja V Tapiainen; Tuomo Mantere; Vesa‐Matti Pohjanen; Hanna Elomaa; Onni Sirkiä; Nicolas Pasquier; Maarit Ahtiainen; Olli Helminen; Erkki‐Ville Wirta; Taneli T Mattila; Outi Lindgren; Janette Savela; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T Seppälä; Jan Böhm; Jukka‐Pekka Mecklin; Markus J Mäkinen; Anne Tuomisto; Johanna Ivaska; Juha P Väyrynen
作者单位1. Translational Medicine Research Unit, Medical Research Center Oulu Oulu University Hospital, and University of Oulu Oulu Finland; 2. Department of Pathology, Hospital Nova of Central Finland Well Being Services County of Central Finland Jyväskylä Finland; 3. Faculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences University of Eastern Finland Kuopio Finland; 4. Turku Bioscience Centre University of Turku and Åbo Akademi University Turku Finland; 5. Research Program in Systems Oncology University of Helsinki Helsinki Finland; 6. Department of Environmental and Biological Sciences University of Eastern Finland Kuopio Finland; 7. Central Finland Biobank Well Being Services County of Central Finland Jyväskylä Finland; 8. Department of Gastroenterology and Alimentary Tract Surgery Tampere University Hospital Tampere Finland; 9. Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre Tampere University Hospital Tampere Finland; 10. Department of Gastrointestinal Surgery, Helsinki University Central Hospital University of Helsinki Helsinki Finland; 11. Applied Tumor Genomics, Research Program Unit University of Helsinki Helsinki Finland; 12. Department of Education and Research Wellbeing Services County of Central Finland Jyväskylä Finland; 13. Faculty of Sport and Health Sciences University of Jyväskylä Jyväskylä Finland; 14. Department of Life Technologies University of Turku Turku Finland; 15. InFLAMES Research Flagship University of Turku Turku Finland; 16. Western Finnish Cancer Center (FICAN West) University of Turku Turku Finland; 17. Foundation for the Finnish Cancer Institute Helsinki Finland
Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis
作者Suneeti R Madhavan; Piper Moore; Rohan Varshney; Miles Montegut; Qiannan Ma; Kayla Klatt; Reshmi Parameswaran; Elif G Ertugral; Chandrasekhar R Kothapalli; Michael C Rudolph; Radhika P Atit
作者单位1. Department of Biology Case Western Reserve University Cleveland OH USA; 2. Department of Biochemistry and Physiology, Harold Hamm Diabetes Center Oklahoma University Health Science Center Oklahoma City OK USA; 3. Department of Pathology Case Western Reserve University Cleveland OH USA; 4. Division of Hematology/Oncology, Department of Medicine Case Western Reserve University Cleveland OH USA; 5. Pediatric Hematology and Oncology, The Angie Fowler Adolescent & Young Adult Cancer Institute University Hospitals Rainbow Babies & Children's Hospital Cleveland OH USA; 6. The Case Comprehensive Cancer Center Case Western Reserve University School of Medicine Cleveland OH USA; 7. Department of Chemical and Biomedical Engineering Cleveland State University Cleveland Ohio USA; 8. Department of Genetics and Genome Sciences Case Western Reserve University Cleveland OH USA; 9. Department of Dermatology Case Western Reserve University Cleveland OH USA
Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease
作者Md Mehedi Hasan; Jenna Craddock; Tingting Gong; Ruth J Lyons; Igor Stevanovski; Sanjog R Chintalaphani; Ira W Deveson; Weerachai Jaratlerdsiri; Kishore R Kumar; Vanessa M Hayes
作者单位1. Ancestry and Health Genomics Laboratory, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health University of Sydney Camperdown New South Wales Australia; 2. School of Health Systems and Public Health, University of Pretoria Pretoria South Africa; 3. Human Phenome Institute Fudan University Shanghai PR China; 4. Cancer Ecosystems Program Garvan Institute of Medical Research and The Kinghorn Cancer Centre Darlinghurst New South Wales Australia; 5. Genomics and Inherited Disease Program The Garvan Institute of Medical Research Darlinghurst New South Wales Australia; 6. Centre for Population Genomics The Garvan Institute of Medical Research Darlinghurst New South Wales Australia; 7. Faculty of Medicine and Health University of New South Wales Sydney New South Wales Australia; 8. Computational Genomics Group, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health University of Sydney Camperdown New South Wales Australia; 9. ANZAC Research Institute, Neurology Department and Molecular Medicine Laboratory, Concord Repatriation General Hospital, Sydney Local Health District University of Sydney Concord New South Wales Australia; 10. Manchester Cancer Research Centre University of Manchester Manchester UK; 11. Norwich Medical School, University of East Anglia Norwich UK
FTO ‐mediated m6A modification of protein disulfide‐isomerase activates VEGFA – VEGFR2 to suppress programmed cell death in osteosarcoma
作者Jiashi Wang; Yingying Hao; Ming He; Weizheng Zhou
作者单位1. Department of Orthopedics Shengjing Hospital of China Medical University Shenyang PR China; 2. Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University Shenyang PR China; 3. Department of Pediatric Orthopaedics Shengjing Hospital of China Medical University Shenyang PR China
Dopamine inhibits retinal pathological neovascularization in the oxygen‐induced retinopathy mouse model
作者Qi Wang; Jiajia Shi; Shuai Ouyang; Tingting Zhang; Haoran Yang; Jiadi Zhu; Luyao Wang; Yuan Lv; Sisi Dong; Ruyi Chen; Xuemei Ling; Shiming Jiao; Mengmeng Dong; Wenjun Yan; Jinglei Yang; Biao Yan; Jiangfan Chen; Jia Qu; Fei Zhao; Xiangtian Zhou
作者单位1. State Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital Wenzhou Medical University Zhejiang PR China; 2. Research Unit of Myopia Basic Research and Clinical Prevention and Control Chinese Academy of Medical Sciences (2019RU025) Zhejiang PR China; 3. Department of Ophthalmology, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China; 4. State Key Laboratory of Eye Health, Department of Ophthalmology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai PR China
Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer
作者Christoph Steup; Julian Dosch; Christopher Dietz‐Fricke; Sara Khosraviseftejani; Esther Engel; Adalbert F de Valk; Dominic Menger; Patrick Welker; Peter J Wild; Kilian B Kennel; Maja Kantlehner; Paul K Ziegler; Florian R Greten
作者单位1. Institute for Tumor Biology and Experimental Therapy Georg‐Speyer‐Haus Frankfurt am Main Germany; 2. Goethe University Frankfurt, Department of Medicine I University Hospital Frankfurt Frankfurt am Main Germany; 3. Frankfurt Cancer Institute, Goethe University Frankfurt Frankfurt am Main Germany; 4. Department of Gastroenterology, Hepatology, Infectious diseases and Endocrinology Hannover Medical School Hannover Germany; 5. Goethe University Frankfurt, Dr. Senckenberg Institutes of Pathology and Human Genetics (SPH), University Frankfurt, University Hospital Frankfurt Frankfurt am Main Germany; 6. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany
CLEC14A correlates with neutrophil infiltration in hepatocellular carcinoma and mediates neutrophil recruitment across liver endothelial cells
作者Joanne M O'Rourke; Dean Kavanagh; Ayla O'Keeffe; Kylie Savoye; Kaiyi Yang; Daniel A Patten; Catherine E Willoughby; Josep M Llovet; Georgiana Neag; Helen L Reeves; Peter W Hewett; Neena Kalia; Tahir Shah; Yuk Ting Ma; Kelly Hunter; Joe Flint; Jack L McMurray; Owen Cain; Fabian Spill; Derek A Mann; Amy J Naylor; Victoria Heath; Christopher J Weston; Roy Bicknell; Shishir Shetty
作者单位1. Centre for Liver and Gastrointestinal Research, Department of Immunology and Immunotherapy, College of Medicine and Health University of Birmingham Birmingham UK; 2. Microcirculation Research Group, Department of Cardiovascular Sciences, College of Medicine and Health University of Birmingham Birmingham UK; 3. School of Mathematics, University of Birmingham Birmingham UK; 4. Mount Sinai Liver Cancer Program, Division of Liver Diseases, Department of Hematology/Oncology, Department of Medicine Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai New York NY USA; 5. Liver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic Universitat de Barcelona Barcelona Spain; 6. Institució Catalana de Recerca i Estudis Avançats (ICREA) Barcelona Spain; 7. Department of Inflammation and Ageing, College of Medicine and Health University of Birmingham Birmingham UK; 8. Newcastle University Translational and Clinical Research Institute, The Medical School Newcastle‐upon‐Tyne UK; 9. Department of Cardiovascular Sciences, College of Medicine and Health University of Birmingham Birmingham UK; 10. Liver Unit Queen Elizabeth Hospital Birmingham UK; 11. Department of Immunology and Immunotherapy University of Birmingham Birmingham UK; 12. Birmingham Tissue Analytics, College of Medicine and Health University of Birmingham Birmingham UK; 13. Department of Pathology Queen Elizabeth Hospital Birmingham Birmingham UK; 14. Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences Newcastle University Newcastle‐upon‐Tyne UK; 15. National Institute for Health Research Birmingham Biomedical Research Centre, University of Birmingham Birmingham UK
Lymph node stromal topology as a hidden regulator of breast cancer outcome: commentary on reticular network analysis †
作者Andrea Vethencourt; Roberto Salgado; Eva Gonzalez‐Suarez
作者单位1. Institut Català d'Oncologia, Medical Oncology Department Breast Cancer Unit Barcelona Spain; 2. IDIBELL, Institut d'Investigació Biomèdica de Bellvitge Barcelona Spain; 3. Department of Pathology ZAS Hospitals Antwerp Belgium; 4. Division of Research Peter MacCallum Cancer Centre Melbourne Victoria Australia; 5. Centro Nacional de Investigaciones Oncológicas (CNIO) Madrid Spain
Targeting fibrosis in the treatment of lower urinary tract dysfunction
作者Ajinkya R Limkar; Sophia M Vrba; Emily A Ricke; Zsuzsanna Fabry; Matthew S Lee; Kevin T McVary; William A Ricke
作者单位1. Department of Urology, George M. O'Brien Center for Research Excellence University of Wisconsin Madison Madison WI USA; 2. Medical Scientist Training Program University of Wisconsin Madison Madison WI USA; 3. Department of Pathology and Laboratory Medicine University of Wisconsin Madison Madison WI USA; 4. Department of Urology, Wexner Medical Center The Ohio State University Columbus OH USA; 5. Loyola University Stritch School of Medicine Maywood IL USA; 6. Center for Male Health Loyola University Medical Center Maywood Maywood IL USA
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