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Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence?
作者Sebastiano Gangemi; Sara Manti; Johann Christian Virchow; Giorgio Walter Canonica
作者单位1. Department of Clinical and Experimental Medicine, Allergy and Clinical Immunology Unit University of Messina Messina Italy; 2. Department of Human Pathology of Adult and Childhood Gaetano Barresi, Pediatric Unit University of Messina Messina Italy; 3. Department for Internal Medicine, Clinic for Pneumology, Allergology, Intensive Care Medicine Universitätemedizin Rostock Rostock Germany; 4. Department of Biomedical Sciences Humanitas University Milan Italy; 5. Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital Rozzano Italy
Plasma Metabolomes Identify Distinct Asthma Metabotypes: Findings From the COREA Cohort
作者Woori Chae; Jin An; Chae Eun Lee; Seo‐Young Kim; Eunse Kim; Hyouk‐Soo Kwon; Woo‐Jung Song; You Sook Cho; Joo‐Youn Cho; Tae‐Bum Kim
作者单位1. Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital Seoul Republic of Korea; 2. Kidney Research Institute Seoul National University Medical Research Center Seoul Republic of Korea; 3. Korea Bioinformation Center Korea Research Institute of Bioscience and Biotechnology Daejeon Republic of Korea; 4. Department of Pulmonary, Allergy and Critical Care Medicine, College of Medicine Kyung Hee University Hospital at Gangdong, Kyung Hee University Seoul Republic of Korea; 5. Department of Allergy and Clinical Immunology Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea; 6. Department of Biomedical Sciences Seoul National University College of Medicine Seoul Republic of Korea
The Airway Transcriptome in Type 2 Cytokine Biomarker‐High and ‐Low Severe Asthma
作者Jiashu Shen; Rekha Chaudhuri; Stephen Bicknell; Adel H. Mansur; Rahul Shrimanker; Ian D. Pavord; Stephen J. Fowler; Vanessa Brown; Lorcan P. McGarvey; Peter H. Howarth; Sven‐Erik Dahlén; Ian M. Adcock; Nazanin Zounemat‐Kermani; Joseph R. Arron; Liam G. Heaney; David F. Choy; Timothy S. C. Hinks; Emanuele Marchi; Peter Bradding; the UK Medical Research Council Refractory Asthma Stratification programme (RASP‐UK)
作者单位1. NIHR Oxford Respiratory BRC, Nuffield Department of Medicine University of Oxford Oxford UK; 2. Gartnavel General Hospital, Glasgow, and Institute of Infection& Immunity University of Glasgow Glasgow UK; 3. University of Birmingham and Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust Birmingham UK; 4. School of Biological Sciences, Faculty of Biology, Medicine and Health University of Manchester, Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust Manchester UK; 5. Wellcome‐Wolfson‐ Centre for Experimental Medicine Queen's University Belfast School of Medicine, Dentistry and Biomedical Sciences Belfast UK; 6. School of Clinical and Experimental Sciences University of Southampton, NIHR Southampton Biomedical Research Centre Southampton UK; 7. Department of Medicine, Huddinge, and Institute of Environmental Medicine, Karolinska Institutet Stockholm Sweden; 8. Centre for Allergy Research Karolinska Institutet Stockholm Sweden; 9. Department of Respiratory Medicine and Allergy Karolinska University Hospital Stockholm Sweden; 10. National Heart and Lung Institute, Imperial College London UK; 11. Data Science Institute, Imperial College London London UK; 12. Genentech, Inc South San Francisco California USA; 13. Department of Respiratory Sciences, University of Leicester NIHR Leicester Biomedical Research Centre, Glenfield Hospital Leicester UK
α4 Nicotinic Acetylcholine Receptor Signaling Exacerbates Type 2 Airway Inflammation
作者Nhi Kieu Thi Le; Akira Kanda; Yuji Kamioka; Keizo Tokuhiro; Yoshiki Kobayashi; Yasutaka Yun; Dan Van Bui; Linh Manh Nguyen; Linh Tai Thi Khuc; Quan Dang Ho; Akihiro Shimamura; Kensuke Suzuki; Akitoshi Mitani; Kenta Fukui; Risaki Kawachi; Mizuki Morita; Hiroshi Iwai; David Dombrowicz; Masao Yagi
作者单位1. Department of Otolaryngology, Head and Neck Surgery Kansai Medical University Osaka Japan; 2. Laboratory Medicine Center Kansai Medical University Hospital Osaka Japan; 3. Department of Molecular Genetics, Institute of Biomedical Science Kansai Medical University Hirakata Osaka Japan; 4. Department of Genome Editing, Institute of Biomedical Science Kansai Medical University Hirakata Osaka Japan; 5. Allergy Center Kansai Medical University Hospital Osaka Japan; 6. Department of Clinical Allergy and Immunology Hanoi Medical University Hanoi Vietnam; 7. Department of Allergy, Immunology and Dermatology E Hospital Hanoi Vietnam; 8. Department of Allergy, Center of Dermato – Venereology, Allergy 108 Military Central Hospital Hanoi Vietnam; 9. University de Lille Inserm, CHU Lille, Institut Pasteur de Lille, U1011‐EGID Lille France
Decalogue of the Declaration of Salamanca: Advancing Undergraduate Education in Allergy and Clinical Immunology Across Europe
作者Maria Jose Torres; Mohamed Shamji; Stefania Arasi; Marta Ferrer; Radoslaw Gawlik; Marta Vazquez‐Ortiz; Carmen Vidal; Asli Gelincik; Cezmi A. Akdis; Ozlem Ceylan; Gulfem Çelik; Tomas Chivato; Stefano del Giacco; Ibon Eguiluz‐Gracia; Maria Marta Escribese; Lene Heise Garvey; Aspasia Karavelia; Ludger Klimek; Paul Lavender; Andre Moreira; Norbert Mülleneisen; Constantinos Pitsios; Ingrid Terreehorst; Sophia Tsabouri; Arantza Vega; Ignacio Davila
作者单位1. Allergy Unit Hospital Regional Universitario de Malaga Malaga Spain; 2. Precision Allergy Translational Hub (PATH), IBIMA‐Plataforma BIONAND. RICORS Inflammatory Diseases Malaga Spain; 3. Department of Medicine and Dermatology University of Malaga Malaga Spain; 4. National Heart and Lung Institute Imperial College London London UK; 5. Wright Fleming Institute Imperial College London London UK; 6. Pediatric Allergology Unit Bambino Gesù Children's Hospital (IRCCS) Rome Italy; 7. Department of Allergy Clínica Universidad de Navarra Pamplona Spain; 8. RICORS Red De Enfermedades Inflamatorias (REI)—RD24/0007/0030 y RD21/0002/0028 Madrid Spain; 9. Department of Internal Medicine, Allergy and Clinical Immunology Medical University of Silesia Katowice Poland; 10. Section of Inflammation, Repair and Development, National Heart and Lung Institute Imperial College London London UK; 11. Allergy Service Complejo Hospitalario Universitario de Santiago Santiago de Compostela Spain; 12. Department of Radiology, Psychiatric, Nursery, Preventive Medicine and Medicine Faculty of Medicine, University of Santiago de Compostela Santiago de Compostela Spain; 13. Division of Immunology and Allergic Diseases, Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University Istanbul Türkiye; 14. Swiss Institute of Allergy and Asthma Research (SIAF) University Zurich Davos Switzerland; 15. EAACI Patient Organisations Committee; 16. Private Practice of Allergy & Clinical Immunology Ankara Türkiye; 17. Departamento Ciencias Médicas Clínicas School of Medicine, University CEU San Pablo Alcorcón Spain; 18. Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy; 19. Departamento de Ciencias Médicas Básicas Facultad de Medicina, Universidad San Pablo CEU Madrid Spain; 20. Department of Environmental Health Harvard T.H. Chan School of Public Health Boston Massachusetts USA; 21. Department of Dermatology and Allergy Allergy Clinic, Copenhagen University Hospital, Gentofte Hellerup Denmark; 22. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark; 23. ENT Department General Hospital of Kalamata Kalamata Greece; 24. Center for Rhinology and Allergology Wiesbaden Germany; 25. Peter Gorer Department of Immunobiology School of Immunology and Microbial Sciences, King's College London London UK; 26. Basic and Clinical Immunology Unit, Department of Pathology Faculty of Medicine, University of Porto Porto Portugal; 27. Serviço de Imunoalergologia Centro Hospitalar Universitário São João Porto Portugal; 28. EPIUnit, Instituto de Saúde Pública Universidade do Porto Porto Portugal; 29. Asthma‐Allergiezentrum Leverkusen Germany; 30. Medical School, University of Cyprus Nicosia Cyprus; 31. Department of Otorhinolaryngology/Head‐Neck Surgery Amsterdam University Medical Center, University of Amsterdam Amsterdam the Netherlands; 32. Faculty of Medicine School of Health Sciences, University of Ioannina Ioannina Greece; 33. Allergy Service Hospital Universitario de Guadalajara Guadalajara Spain; 34. Faculty of Medicine, University of Salamanca Salamanca Spain; 35. Allergy Service University Hospital of Salamanca Salamanca Spain
Longer Asthma Duration Is Associated With Elevated Non‐ T2 Sputum Biomarkers and Reduced T2 Inflammation in Severe Asthma
作者Freda Yang; Sujin Seo; Takehiro Hasegawa; Chloe I. Bloom; Nazanin Zounemat‐Kermani; Pankaj K. Bhavsar; Katie Raby; Ian M. Adcock; Sungho Won; Tae‐Bum Kim; Kian Fan Chung; the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U‐BIOPRED) Consortium
作者单位1. National Heart & Lung Institute, Imperial College London London UK; 2. Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust London UK; 3. Institute of Health and Environment, Seoul National University Seoul Republic of Korea; 4. Sysmex R&D Center Europe GmbH Hamburg Germany; 5. Data Science Institute, Imperial College London London UK; 6. Department of Public Health Sciences Graduate School of Public Health, Seoul National University Seoul Republic of Korea; 7. Department of Allergy and Clinical Immunology Asan Medical Center, University of Ulsan College of Medicine Seoul Korea
Real‐World Evaluation of AI‐Assisted Readout of Skin Prick Automated Test Results
作者Julie van Waterschoot; Sven F. Seys; Ilan Baron; Gregory Clement; Julie Craps; Tessa Dieudonné; Glynnis De Greve; Joris De Medts; Natascha Friese; Jan Hagemann; Farah Hannachi; Sofie Happaerts; Edwin Hill; Valérie Hox; Bruno Lantsoght; Winde Lemmens; Patrick Levie; Christophe Libeer; Yves Mentens; Tim S. Nawrot; Haïg Nigolian; Richard Oei; Bas op de Coul; Maike Pincus; Mahadi Salah; Christian Schellemans; Salem Tamim; Olivier Vanderveken; Klara Van Gool; Valérie Verkest; Anne‐Sophie Vinck; Audrey Weinquin; Rembert Daems; Dirk Loeckx; Senne Gorris; Adam M. Chaker; Laura Van Gerven
作者单位1. Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation KU Leuven Leuven Belgium; 2. Department of Otorhinolaryngology‐Head and Neck Surgery UZ Leuven Leuven Belgium; 3. Department of Otolaryngology, Head and Neck Surgery Medical University of Vienna Vienna Austria; 4. Hippo Dx Hasselt Belgium; 5. Department of Otorhinolaryngology‐Head and Neck Surgery AZ Jan Portaels Vilvoorde Belgium; 6. Otorhinolaryngology‐Head and Neck Surgery Clinique Royale Oostende Belgium; 7. Department of Pneumology AZ HH Lier Lier Belgium; 8. Department of Pneumology AZ HH Mol Mol Belgium; 9. Department of Otorhinolaryngology‐Head and Neck Surgery ZAS Sint‐Augustinus Antwerp Belgium; 10. Department of Otorhinolaryngology‐Head and Neck Surgery AZ Delta Roeselare Belgium; 11. HNO Praxis Weil der Stadt Germany; 12. Center for Rhinology and Allergology Wiesbaden Germany; 13. Immunology‐Allergology Unit Centre Hospitalier Luxembourg Luxembourg Luxembourg; 14. Department of Pneumology AZ Klina Brasschaat Belgium; 15. Department of Pneumology AZ Glorieux Ronse Belgium; 16. Service d'Otorhinolaryngologie, Cliniques Universitaires Saint‐Luc Brussels Belgium; 17. NKO Dr Lantsoght Knokke Belgium; 18. Department of Otorhinolaryngology‐Head and Neck Surgery ZOL Genk Belgium; 19. Cabinet ORL Messidor Brussels Belgium; 20. Department of Pneumology AZ Sint‐Maarten Mechelen Belgium; 21. Department of Pneumology AZ Herentals Herentals Belgium; 22. Center for Environmental Sciences Hasselt University Diepenbeek Belgium; 23. Service D'allergology Genève Switzerland; 24. Department of Allergology DC Klinieken Groningen the Netherlands; 25. Otorhinolaryngology KNO Medisch Centrum Waardenburg the Netherlands; 26. Kinderartzpraxis Karow Berlin Germany; 27. Department of Otorhinolaryngology‐Head and Neck Surgery AZ Sint‐Elisabeth Zottegem Belgium; 28. Doktershuis Antverpia Antwerp Belgium; 29. Service d'Allergology Vivalia Arlon Belgium; 30. Department of Otorhinolaryngology‐Head and Neck Surgery UZA Antwerp Belgium; 31. NKO Kalmthout Kalmthout Belgium; 32. Department of Otorhinolaryngology‐Head and Neck Surgery ZAS Sint‐Vincentius Antwerp Belgium; 33. Department of Otorhinolaryngology‐Head and Neck Surgery AZ Sint‐Jan Brugge Belgium; 34. Cabinet ORL Centre Hospitalier du Nord Ettelbruck Luxembourg; 35. IDLAB Ghent University‐imec Ghent Belgium; 36. Department of Otorhinolaryngology and Head and Neck Surgery AZ Herentals Herentals Belgium; 37. Department of Otorhinolaryngology and Center of Allergy and Environment, TUM School of Medicine and Health, TUM University Hospital Klinikum rechts der Isar Technical University of Munich Munich Germany; 38. Laboratory of Experimental Otorhinolaryngology, Department of Neurosciences KU Leuven Leuven Belgium
Modeling Hereditary Angioedema With Personalized Expanded Potential Stem Cell‐Derived Hepatocytes: A CRISPR ‐Validated Platform for Mutation‐Specific Mechanisms and Therapeutic Innovation
作者Xueyan Liu; Yuxin Wang; Jane C. Y. Wong; Xiang Zhang; Cuixi Wu; Pengyu Chen; Yunzhi Yang; Pentao Liu; Chak Sing Lau; Matthew Cook; Philip Hei Li
作者单位1. Division of Rheumatology and Clinical Immunology, Department of Medicine Queen Mary Hospital, University of Hong Kong Hong Kong SAR China; 2. InnoHK Centre for Translational Stem Cell Biology Hong Kong Science Park Hong Kong SAR China; 3. School of Biomedical Sciences University of Hong Kong Hong Kong SAR China; 4. School of Clinical Medicine University of Cambridge Cambridge UK
Algorithms in Allergy : Diagnosis of Concomitant Inducible Laryngeal Obstruction in Adults With Asthma
作者Andrew P. Hearn; Claire Slinger; Jennifer M. Butler; Jemma Haines; James H. Hull; Stephen J. Fowler
作者单位1. Department of Respiratory Medicine Barts Health NHS Trust London UK; 2. Lancashire Teaching Hospitals NHS Foundation Trust, Preston, Lancashire and Clinical Audiology, Speech and Language Research Centre Queen Margaret University Edinburgh UK; 3. Department of Respiratory Medicine Northumbria NHS Foundation Trust Newcastle upon Tyne UK; 4. NIHR Manchester Biomedical Research Centre Manchester University NHS Foundation Trust Manchester UK; 5. Respiratory Medicine, Royal Brompton Hospital Institute of Sport, Exercise and Health (ISEH) London UK; 6. Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences The University of Manchester Manchester UK
Clinical Features of Cellular Senescence Pathways in Severe Asthma
作者Woo‐Jung Song; Nazanin Zounemat Kermani; Ali Versi; Stephany Sánchez‐Ovando; Jodie Louise Simpson; Peter A. Wark; Katherine Joanne Baines; Sven‐Erik Dahlén; Ratko Djukanovic; Yike Guo; Ian M. Adcock; Kian Fan Chung; the U‐BIOPRED Study Group
作者单位1. Department of Allergy and Clinical Immunology, Asan Medical Center University of Ulsan College of Medicine Seoul Korea; 2. National Heart and Lung Institute Imperial College London London UK; 3. Department of Computing, Data Science Institute Imperial College London London UK; 4. Priority Research Centre for Healthy Lungs, Faculty of Health and Medicine University of Newcastle Newcastle New South Wales Australia; 5. Allergy, Immunology and Respiratory Medicine Alfred Health Melbourne Victoria Australia; 6. Centre for Allergy Research Karolinska Institute Stockholm Sweden; 7. Faculty of Medicine Southampton University Southampton UK; 8. NIHR Southampton Respiratory Biomedical Research Unit University Hospital Southampton Southampton UK
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