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Exploratory proteomic and metabolomic profiling of pleural effusions identifies histone H4 and alanine as promising complementary markers for pleural tuberculosis
作者Débora Santos da Silva; Cristiana Santos de Macedo; Raquel da Silva Corrêa; Thyago Leal Calvo; Tatiana El-Bacha; Ana Paula Masson; Vitor Marcel Faça; Renan Jeremias da Silva; Maria Helena Féres Saad; Thiago Thomaz Mafort; Ana Paula Santos; Rogerio Rufino; Flavio Alves Lara; Luciana Silva Rodrigues; Leticia Miranda Santos Lery
作者单位Cellular Microbiology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, 21040-900, Brazil; Center for Technological Development in Health, FIOCRUZ, Rio de Janeiro, 21040-900, Brazil; Laboratory of Immunopathology, Medical Sciences Faculty, Rio de Janeiro State University (UERJ), Rio de Janeiro, 20550-900, Brazil; Center for CRISPR Target Discovery, Innovative Genomics Institute, UC Berkeley, California, 94704, USA; Pioneer Science Initiative D’Or Institute for Research and Education, Rio de Janeiro, 22281-100, Brazil; LeBioME-Bioactives, Mitochondrial and Placental Metabolism Core, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-853, Brazil; Cancer Proteomics Laboratory, Biochemistry and Immunology Department, Medical Sciences Faculty at Ribeirão Preto, São Paulo University, São Paulo, 14049-900, Brazil; Pulmonology and Tuberculosis Service, Pedro Ernesto University Hospital, UERJ, Rio de Janeiro, 20551-030, Brazil; Department of Thoracic Diseases, Medical Sciences Faculty, UERJ, Rio de Janeiro, 20550-900, Brazil; General Pathology Service, Pedro Ernesto University Hospital, UERJ, Rio de Janeiro, 20551-030, Brazil
Differences in T cell immune responses to novel Mycobacterium tuberculosis antigens (PPE68, PE9, and IrtA) in tuberculosis patients in southern Thailand
作者Pyae Sone Oo; Jomkwan Ongarj; Ratchanon Sophonmanee; Narisa Mothong; Sahasawat Suksan; Natapohn Saowaphong; Nawamin Pinpathomrat
作者单位Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand
Dynamic kinetics and clinical utility of a ddPCR-based 3-gene host transcriptional signature for monitoring tuberculosis treatment response: a prospective multicenter study
作者Qian Qiu; Bo Liu; Wei Zhang; Ping Huang; Haiqing Liu; Senlu Wang; Bing Zhao; Hui Xia; Yang Zheng; Yuanyuan Song; Yang Zhou; Ruida Xing; Xichao Ou; Yanlin Zhao
作者单位National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention (Chinese Academy of Preventive Medicine), Beijing, China; Department of Infectious Diseases, People's Hospital of Liuyang City, Liuyang, China; Department of Clinical Laboratory, Fuyang Second People's Hospital (Fuyang Infectious Disease Clinical College of Anhui Medical University), Fuyang, China; Center for Tuberculosis and Leprosy Prevention and Control, The Center for Disease Control and Prevention of Xinjing Uygur Autonomous Region, Urumchi, China
Glycaemic burden disrupts innate immunity in TB by modulating CD206 expression and macrophage antimicrobial responses
作者Alisha Arora; Sudhasini Panda; Kalpana Luthra; Anant Mohan; Yashdeep Gupta; Umesh Kumar; Archana Singh
作者单位Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, 110029, India; Department of Medicine, All India Institute of Medical Sciences, New Delhi, 110029, India; Nehru Nagar Chest and T.B. Hospital, State T.B. Cell, New Delhi, India
Drug resistance in tuberculous meningitis: A laboratory-based observational study from Northern India's tertiary care referral centre
作者Kalpana Kuntal; Manu Singh; Parul Jain; Rashmi Ratnam; Urmila Singh; Vijay Kumar
作者单位Department of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh, India
FadR subfamily of transcriptional regulators are dispensable for the pathogenesis of Mycobacterium tuberculosis
作者Saurabh Chugh; Bhupinder Singh; Neeraj Kumar Chauhan; Deepika Chaudhary; Manisha Singh; Arun Sharma; Munmun Bhasin; Niharika; Pankaj Chopra; Manisha Priya; Shailendra Asthana; Vijay Singh; Raghavan Varadarajan; Ramandeep Singh
作者单位Translational Health Science and Technology Institute, Faridabad, Haryana, 121001, India; Molecular Biophysics Unit, Indian Institute of Science, Bengaluru, India; Central University of South Bihar, Gaya, Bihar, India
Multiparametric flow cytometry immune profiling of pulmonary and extra-pulmonary tuberculosis reveals distinct blood-based biomarker signatures
作者Kalaiarasan Ellappan; Noyal Mariya Joseph; Prakash Babu Narasimhan; Harriet N. Garlant; Seshadri Vasan; Komal Jain; Saka Vinod Kumar; Vishnukanth Govindaraj; Vir Singh Negi; Karen E. Kempsell
作者单位Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India; Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India; CSO Group - Countermeasures Development, Evaluation and Preparedness Division, UK Health Security Agency, Salisbury, United Kingdom; Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India; Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India; Edith Cowan University, School of Medical and Health Sciences, Joondalup, WA, 6027, Australia
Host-derived proteomic biomarkers for discriminating the tuberculosis disease spectrum in a Brazilian cohort
作者Matheus Rogerio Almeida; Anouk van Hooij; Louise Pierneef; Gaby Wassenaar; Raquel da Silva Corrêa; Roberto Stefan de Almeida Ribeiro; Luana Karen Correia dos Santos; Ariane Leite de Oliveira; Ana Paula Santos; Thiago Thomaz Mafort; Rogério Rufino; Cristiana Santos de Macedo; Paul L.A.M. Corstjens; Luciana Silva Rodrigues; Annemieke Geluk
作者单位Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), the Netherlands; Center for Technological Development in Health, Fiocruz, Rio de Janeiro, Brazil; Laboratory of Immunopathology, Medical Sciences Faculty, Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil; Laboratory of Molecular Biology Applied to Mycobacteria, Fiocruz, Rio de Janeiro, Brazil; Multi-user Clinical Research Laboratory, Faculty of Medical Sciences, Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil; Pulmonary and Phthisiology Division, Pedro Ernesto University Hospital (HUPE), UERJ, Rio de Janeiro, Brazil; Dept. Cell and Chemical Biology, Leiden University Medical Center, the Netherlands
Association between gut microbiota and white matter microstructural damage in tuberculous meningitis patients
作者Zexuan Xu; Yanpin Liu; Yilin Wang; Junying Zhao; Yichuan Wang; Lijun Chen; Dailun Hou
作者单位Department of Medical Imaging, Beijing Chest Hospital, Capital Medical University, Beijing, China; Department of Medical Imaging, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China; National Engineering Centre of Dairy for Maternal and Child Health, Beijing Sanyuan Foods Co. Ltd., Beijing, China
Context-dependent transcriptional and epigenetic reprogramming shapes neutrophil antimicrobial and immunoregulatory functions in tuberculosis
作者Cicero José Luíz dos Ramos Almeida; Ricardo Cardoso Castro; Priscilla Mariane Cardoso-Silva; Fabiana Albani Zambuzi; Patrick Fernandes Silva; Veronica Soares Brauer; Humberto Dorigetto Gravina; Caroline Fontanari; Valdes Roberto Bollela; Fabiani Gai Frantz
作者单位Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil; Faculdade de Ciências da Saúde de Barretos Dr. Paulo Prata, Barretos, São Paulo, Brazil; Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
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