医学
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An integrated structural and functional profiling approach uncovers the mechanisms of pregnane X receptor binding and activation by pharmaceutical and environmental compounds
作者Quentin Derosa; Coralie Carivenc; Savannah Sirounian; Marina Grimaldi; Abdelhay Boulahtouf; Vanessa Delfosse; Patrick Balaguer; William Bourguet
作者单位Institut de Recherche en Cancérologie de Montpellier, Inserm U1194, Montpellier, France; Center for Structural Biology (CBS), University of Montpellier, Inserm, CNRS, Montpellier, France
Neuroprotective in vitro effects of histone deacetylase 6–selective inhibitor SW-100 toward oxaliplatin-derived toxicity
作者Angelica Squarzoni; Arianna Scuteri; Elisabetta Donzelli; Virginia Rodriguez-Menendez; Guido Cavaletti
作者单位Experimental Neurology Unit and Milan Centre for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza (MB), Italy; PhD Program in Neuroscience, University of Milano-Bicocca, Milan, Italy
Effects of ivermectin on the activation and desensitization of the human GABAA receptor
作者Spencer R. Pierce; Allison L. Germann; Ka Tak Tsoi; Gustav Akk
作者单位Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri; Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri
Molecular pharmacology of mGlu7/8 heterodimers reveals unique properties of orthosteric agonists and positive allosteric modulators
作者Anthony S. Ferranti; Youhyun Noh; Xia Lei; Xin Lin; Joseph D. Bungard; Wesley B. Asher; Jonathan A. Javitch; Colleen M. Niswender
作者单位Department of Pharmacology, Vanderbilt University, Nashville, Tennessee; Warren Center for Neuroscience Drug Discovery and Vanderbilt Institute for Translational Advances, Nashville, Tennessee; Departments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee
Identification and characterization of selective inhibitors of Nav1.9 voltage dependent sodium channels
作者Franck Potet; Sonia Santos; Allison Gallucci; Jonathan Theile; Katrina Yoger; Zhixin Lin; Sylvain Lebreton; Robert Volkmann; Robert Dow; Mark Elban; Chongyang Han; Jared Spletstoser; Jay Spampanato; Gareth Young; Neil A. Castle
作者单位OmniAb, Inc, Durham, North Carolina; BioPharmaWorks LLC, Groton, Connecticut; GlaxoSmithKline (GSK), Collegeville, Pennsylvania
Mechanisms for enhancement of μ-opioid receptor-mediated antinociception in the central nervous system through gallein-dependent modulation of downstream G protein βγ subunit signaling
作者Jacob A. Ormes; Alan V. Smrcka; Emily M. Jutkiewicz
作者单位Department of Pharmacology, University of Michigan, Ann Arbor, Michigan
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