医学
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Integrated analysis of network pharmacology, machine learning, and cell experiments revealed the mechanism by which Neoastilbin (a component of Xiaobi Pill) alleviates rheumatoid arthritis in vitro via targeting the MMP13/NF-κB pathway
作者Zelin Zhu; Junfu Ma; Jiakang Cui; Xiyun Miao; Yunan Zhang; Jing Zhao; Chengfei Lu; Haolin Li; Peipei Shao; Qingliang Meng; Zengyu Cheng
作者单位Department of Rheumatology, Henan University of Chinese Medicine, Zhengzhou, Henan, China; Department of Rheumatology, The Second Affiliated Hospital to Henan University of Chinese Medicine, Henan Province Hospital of Chinese Medicine, Zhengzhou, Henan, China
GC–MS profiling, molecular modeling, and pharmacological evaluation of a polyherbal formulation of Curcuma longa, Zingiber officinale, and Allium sativum against Plasmodium berghei
作者Iwara A. Iwara; Collins Igajah; Katherine A. Eteng; Godwin O. Igile; Destiny Bisong; Eyong U. Eyong
作者单位Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Nigeria
Copper indium selenium nanozyme for atherosclerosis therapy by redox rebalancing and senescence suppression
作者Chunxiu Tian; Ruihua Wang; Yuewei Li; Yuxia Gao
作者单位Department of Graduate School, Tianjin Medical University, Tianjin, China; Department of Cardiology, Changzhi Medical College Affiliated Hospital, Changzhi People’s Hospital, Changzhi, China; Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, China
Design, synthesis, and biological insights of a novel imidazole-based heterocycle: A combined spectroscopic and DFT approach
作者D. Rajaraman; P. Sivakumar; S. Sonadevi; Shiek S.S.J. Ahmed; A. Dhandapani; K. Nagaraj; K. Gopichand
作者单位Department of Chemistry, St. Peter's Engineering College, Hyderabad, Telangana, India; Department of Physics, Kaveri University, Gowraram, Siddipet, Telangana 502279, India; College of Emerging Sciences, Karpaga Vinayaga Educational Lore for Learning (KVELL), Padalam, Tamil Nadu 603 308, India; Department of Chemistry, C. K. College of Engineering and Technology, Cuddalore, Tamil Nadu, India; Biomedical & Nano-Drug Formulation Laboratory, Department of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India
Novel bis-pyrano[2,3-c]pyrazoles as potential antidiabetic agents: Synthesis, biological evaluation, and computational insights
作者Mohammed Al-Ghorbani; Mezna Saleh Altowyan; Khulud M. Al-Taisan; Saad Alrashdi; Ramith Ramu; Mohammed Baashen
作者单位Department of Chemistry, College of Science, Taibah University, Madinah, Saudi Arabia; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia; Department of Chemistry, College of Science, King Faisal University, P.O. Box 400, Hofuf 31982, Saudi Arabia; Department of Chemistry, College of Science, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia; Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education & Research, Mysuru, Karnataka 570015, India; Department of Chemistry, Science and Humanities College, Shaqra University, Ad-Dawadmi 11911, Saudi Arabia
In-silico evaluation of zeaxanthin and riboflavin from moringa oleifera as potential insulin receptor modulators for diabetes management
作者Vijaykumar Shevale; Sanjana Khanai; Sandhya Khot; Deepashree Gond
作者单位Department of Pharmacology, KLE Society’s College of Pharmacy, Nipani, Karnataka 591237, India
Periplaneta americana extracts induce PI3K/AKT signaling and mitochondrial function enhancement to promote liver regeneration through MCJ down-regulation
作者Lifang Liu; Zhihong Yang; Chenjian Xie; Di Zeng; Meiyan Zhang; Bangxu Wu; Hanrui Shao; Li Lang; Yan Wang; Kun Wang; Yingying Zou; Xie Wang
作者单位Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China; Department of Pathology, Chengdu Fifth People’s Hospital, Chengdu 611130, China; Department of Pathology, Baoji Central Hospital, Baoji 721000, China; Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China; Department of Pathology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650500, China; Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650500, China
Integrating weighted gene co-expression network analysis and machine learning reveals that RETN drives Methicillin-resistant Staphylococcus aureus-induced lung epithelial cell injury by regulating inflammation and oxidative stress
作者Shuling Deng; Wenyan Guo; Mingyi Lv
作者单位Department of Internal Medicine ICU, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
A rifampin-loaded porous bioceramic box as a drug delivery system for spinal tuberculosis
作者Jie Guan; Jiakuan Ye; Gangfeng Hu; Yiming Hu; Haitao Ma; Liming Zhu
作者单位Department of Orthopedics, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
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