医学
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Development of spectroscopic methods using charge transfer complex for the quantitative estimation of proguanil hydrochloride: Insights from greenness evaluation, BSA binding, molecular docking, antimicrobial studies and Insilico toxicity assessment
作者Abdullah Mannan; Adila Khalil; Mohammad Kashif; Aliya Firdaus
作者单位Analytical Chemistry Section, Department of Chemistry, Aligarh Muslim University, Aligarh, (U.P.) 202002, India; Bio-control Research Laboratory, Integral University, Kursi Road, Lucknow, (U.P.) 226026, India
Advancing safety pharmacology: Emerging technologies, innovative methods, and future directions
作者Michael K. Pugsley; Brett R. Winters; Lutfiya Miller; Simon Authier; Michael J. Curtis
作者单位Toxicology & Safety Pharmacology, Cytokinetics, South San Francisco, CA 94080, USA; 3rdAI LLC, Birmingham, AL, USA; Charles River Laboratories, Laval, QC H7V 4B3, Canada; Cardiovascular Division, King's College London, Rayne Institute, St Thomas' Hospital, London SE17EH, UK
Detecting drug-induced EEG alterations with machine learning: A methodological proof-of-concept study in rats treated with MK-801
作者Matthieu Basset; Paul-Emeric Saunier; Geoffrey Viardot; Philippe L'Hostis; Eric Delpy; Kevin Carvalho; Florian W. Adraoui
作者单位BIOTRIAL DATASCIENCE, 4 chemin de l'Arenas, 06200 Nice, France; BIOTRIAL NEUROSCIENCE, Avenue de Bruxelles, 68350 Brunstatt-Didenheim, France; BIOTRIAL NEUROSCIENCE, 7-9 rue Jean-Louis Bertrand, 35000 Rennes, France; BIOTRIAL PHARMACOLOGY, 7-9 rue Jean-Louis Bertrand, 35000 Rennes, France
In silico study: ADMET-driven pharmacokinetic profiling of antiviral compounds for pre-clinical screening framework of intranasal drug development
作者Jeerakit Kerdsiri; Tasana Pitaksuteepong; Neal M. Davies; Nitra Nuengchamnong; Kowit Hengphasatporn; Shengnan Zhao; Siwaporn Boonyasuppayakorn; Parvapan Bhattarakosol; Yasuteru Shigeta; Raimar Loebenberg; Neti Waranuch
作者单位Cosmetics and Natural Products Research Center, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand; Faculty of Pharmacy and Pharmaceutical Sciences, Katz Centre for Pharmacy and Health Research, University of Alberta, AB T6G2E1, Canada; Science Laboratory Center, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand; Center for Computational Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan; Department of Biochemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
From surplus to scientific value: Repurposing vascular tissues for organ bath standardization to de-risk vasoactive liabilities
作者Laura Coonen; Cristina Altrocchi; Jeroen Tolboom; Hans De Wolf; Mohamed Kreir; David J. Gallacher
作者单位Johnson and Johnson, Innovative Medicine, Beerse, Belgium
Analytical performance of poly(L-cysteine) modified pencil graphite electrode for dapsone detection
作者Santosh B. Konnur; Jayant I. Gowda; Sharanappa T. Nandibewoor
作者单位P. G. Department of Studies in Chemistry, Karnatak University, Dharwad 580003, India; Department of Chemistry, BLDEA's Commerce, BHS Arts and TGP Science College, Jamkhandi 587301, Karnataka, India; Research Centre in Chemistry, BLDEA's Commerce, B.H.S. Arts and T.G.P. Science College, Affiliated to Bagalkot University, Jamkhandi 587301, Karnataka, India
Rapid and sensitive quantification of pemetrexed in human plasma by LC–MS/MS using a stable isotope-Labeled internal standard for therapeutic drug monitoring
作者Haoran Yang; Huimin Yu; Tang Tang; Huijie Yue; Xiaoyi Chen; Jieyu Zhang; Yuzhu Cao; Qing Zhou
作者单位Department of Clinical Pharmacy, Jinling Hospital Affiliated to Nanjing University, Nanjing 210002, China; Department of pharmacy, Anhui institute of medicine, Hefei, Anhui 230001, China; Clinical Pharmacy of Shanghai Fourth People's Hospital Affiliated Tongji University, Shanghai 200434, China
The INSPIRE doctoral network in safety pharmacology – Looking back and ahead
作者Pieter-Jan Guns; Brigitta Rita Szabó; Martina Cherubin; Haibo Liu; Christian Klein; Bohdan Hlova; Tommaso Biagini; Elham Ataei Alizadeh; Sara Costa-Faya; Charles Henri Van Assche; Callan D. Wesley; Marieke Van Daele; Patrizia Pannucci; Benji Van Berlo; Dustin Nicolas Krüger; Anna S. Savchenko; Guido R.Y. De Meyer; Jean-Pierre Valentin
作者单位Physiopharmacology, GENCOR, University of Antwerp, Antwerp, Belgium; Ncardia Services BV – Leiden, the Netherlands; UCB, Patient Solutions, Early Clinical Development and Translational Science, Non-Clinical Safety Evaluation, Braine-l'Alleud, Belgium; Center of Medical Genetics, GENCOR, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium; NOTOCORD Systems, Instem, Le Pecq, France; TSE Systems GmbH – Berlin, Germany; Human and Animal Physiology, Wageningen University, Wageningen, the Netherlands; Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel; Boehringer Ingelheim Pharma GmbH & Co KG – Biberach an der Riss, Germany; INRIA (Institut National de Recherche en Informatique et Automatique) – Paris, France; The Maastricht MultiModal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, the Netherlands; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, United Kingdom; Centre of Membrane Proteins and Receptors, University of Birmingham and Nottingham, The Midlands, UK; Department of Cardiology, CARIM, Maastricht University Medical Center, Maastricht, the Netherlands; Infla-Med, Consortium of Excellence, University of Antwerp, Antwerp, Belgium
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