医学
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From undruggable to degradable: development of anthraquinone-based PROTACs against MITF for skin-lightening applications
作者Meng Xu; Zi-Qing Zhang; Pei-Xi Zhang; Xin-Yi He; Xin-Yue Pan; Cai-Xia Huang; Yan-Jun Di; Yan Wang; Jie-Qing Liu
作者单位1. School of Medicine, Huaqiao University; 2. School of Chemistry and Chemical Engineering, Shaanxi Normal University; 3. Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Medicine, Huaqiao University
Guomin decoction ameliorates atopic dermatitis by restoring M1/M2 macrophage polarization balance via dual regulation of MAPK/NF-κB and JAK-STAT pathways
作者Jing Li; Yan-Jiao Liu; Xin-Jia Zhang; Chu-Yao Li; Rui-Ju Ma; Zhi-Chang Xu; Rui-Rui Wang; Yi Zhang; Li-Juan Zhang
作者单位1. School of Chinese Materia Medica, Yunnan University of Chinese Medicine; 2. Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine; 3. Medicine School of Basic Medical Sciences, Yunnan University of Chinese Medicine
Myromopholine A, a new unusual diketomorpholine from Myrothecium gramineum
作者Run-Qiao Kuang; Hui-Jun Huang; Shu-Tai Jiang; Guo-Dong Chen; Huan Zhao; Dan Hu; Xing-Zhong Liu; Chuan-Xi Wang; Hao Gao; Xin-Sheng Yao
作者单位1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University; 2. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
The guardian that guides: cinnamic acid enhances oral bioavailability of diverse TCM components by reinforcing rather than disrupting intestinal barrier integrity
作者Fang-Fang Fan; Meng-Yao Cui; Rui-Han Guo; Kun Pan; Hong-Ye Xu; Xiao-Qin Chu
作者单位1. School of Pharmacy, Anhui University of Chinese Medicine; 2. Quality Assurance Department, Tongling Institutes for Food and Drug Control; 3. Institute of Pharmaceutics, Anhui Academy of Chinese Medicine; 4. Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application; 5. Engineering Technology Research Center of Modern Pharmaceutical Preparation
Survey of natural products reported by Asian research groups in 2024
作者Qian-Ru Wang; Shu-Yang Wang; Shuang-Gang Ma; Shi-Shan Yu
作者单位1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Research on the effects and mechanisms of the Yiqi Huoxue Recipe in improving renal injury in diabetic nephropathy through the HIF-1 pathway
作者Wen-Di Niu; Hao-Wei Liang; Lue Hong; Jin-Xing He; Jia-Hui Qian; Fei Pan; Zhi-Wei Xu; Hui Wang
作者单位1. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University; 2. Fenghua District Traditional Chinese Medicine Hospital of Ningbo; 3. The First Clinical Medical College of Zhejiang University of Traditional Chinese Medicine; 4. Hangzhou Lin’an District Hospital of Traditional Chinese Medicine; 5. Jinhua Academy, Zhejiang Chinese Medical University
Microbial transformation of cycloastragenol by Penicillium spinulosum AS3.149
作者Xin-Yu Cai; Ji-Mei Liu; Jun-Gui Dai
作者单位1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Biosynthesis of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Panax ginseng nanoemulsion: a promising pre-clinical modality for ameliorating male infertility via manipulation of PI3K/AKT/mTOR signaling pathway
作者Basma I. El-Shimi; Rafat M. Mohareb; Hanaa H. Ahmed; Khaled F. Mahmoud; Demiana H. Hanna; Rehab S. Abohashem
作者单位1. Chemistry Department, Faculty of Science, Cairo University; 2. Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre; 3. Stem Cell Lab., Centre of Excellence for Advanced Sciences, National Research Centre; 4. Food Technology Department, Food Industry and Nutrition Research Institute, National Research Centre
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